4 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Systems biology of liver cancer: an integrative genomic-epigenomic approach (MODHEP)
Date du début: 1 janv. 2011, Date de fin: 30 juin 2016,
"Cancer is a complex disease involving multiple genetic and epigenetic events occurring, and influencing each other, over a long period of time. Understanding cancer, and ultimately developing effective targeted therapies, will therefore require that mutations and epigenetic alterations be systematically investigated during the multiple stages of disease development, from identifiable pre-neoplast ...
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18
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TERMINÉ
Determining the roles of the nuclear periphery in mammalian genome function (FunctionalEdge)
Date du début: 1 mars 2010, Date de fin: 29 févr. 2016,
DNA sequence and epigenetic chromatin maps are important in understanding how genomes are regulated. However, these maps are linear and do not account for the three-dimensional context within which the genome functions in the cell. The spatial organisation of the genome in the nucleus is not random and is conserved in evolution, implying that it is under functional selection. This proposal aims to ...
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2
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TERMINÉ
“The International Data Coordination Centre” (I-DCC)
Date du début: 1 janv. 2009, Date de fin: 30 sept. 2013,
"The I-DCC coordination and support project responds to the topic defined by HEALTH-2007-2.1.2-6 “International activities in large-scale data gathering and systems biology”. I-DCC integrates European skills, efforts, resources, and infrastructure in an international collaborative programme to establish a European Data Coordination Centre for mouse genetic resources. Large-scale mouse mutagenesis ...
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10
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TERMINÉ
Genomic Regulatory Systems of Human X-linked neurological diseases (NeuroXsys)
Date du début: 1 juin 2009, Date de fin: 30 nov. 2012,
NeuroXsys will generate regulatory maps and models of the human X chromosome based on evolutionary conservation, with special attention to genes and regions implicated in X-linked neurological diseases. Vertebrate chromosomes are subdivided into domains of genomic regulatory blocks (GRBs) and NeuroXsys aims to map all GRBs on the X chromosome through bioinformatic approaches, extract gene regulato ...
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