8 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
DIabetes REsearCh on patient sTratification (DIRECT)
Date du début: 1 févr. 2012, Date de fin: 31 janv. 2019,
The overarching aims of the DIRECT consortium, consisting of 20 leading academic groups in diabetes and 5 EFPIA companies, are to identify biomarkers that address current bottlenecks in diabetes drug development and to develop a stratified medicines approach to treatment of type 2 diabetes with either existing or novel therapies.There is heterogeneity in who develops diabetes, the rate at which th ...
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27
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TERMINÉ
Cracking the SUMO Signalling Code (DECODINGSUMO)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
"Functional activity of proteins is tightly controlled via reversible post-translational modifications including phosphorylation, acetylation and ubiquitylation. These modifications enable the orchestration of cellular responses to a wide variety of stimuli. Due to these modifications, proteomes are overwhelmingly complex. Progress in the field has been greatly accelerated by the development of no ...
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1
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TERMINÉ
Methods for Integrated analysis of Multiple Omics datasets (MIMOmics)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,
MIMOmics develops statistical methods for the integrated analysis of metabolomics, proteomics, glycomics and genomic datasets in large studies. Our project is based on our involvement in studies participating in EU funded projects, i.e. GEHA, IDEAL, Mark-Age, ENGAGE and EuroSpan. In these consortia the primary goal is to identify molecular profiles that monitor and explain complex traits with nove ...
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15
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TERMINÉ
STRATEGY TO INHIBIT TGF-Beta IN LIVER DISEASE (IT-LIVER)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,
Chronic liver diseases (CLD) and their end-stages, cirrhosis and hepatocellular carcinoma (HCC), are leading causes of morbidity and mortality worldwide with enormous socio-economic costs. Patients with liver cirrhosis are at high risk of deadly hepatic failure and over 80% of HCC develop on a cirrhotic background. HCC ranks as the 5th most common cancer and with >600,000 deaths per annum it const ...
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12
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TERMINÉ
Integrated research on DEvelopmental determinants of Aging and Longevity (IDEAL)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2016,
"IDEAL will obtain insight into the role of early life conditions affecting late-life health, disease and aging, and the role of epigenetic regulation therein. IDEAL will identify the determinants and targets of this epigenetic regulation utilizing a resource of unique human cohorts and animal studies that allow testing of hypotheses on the link between development and aging.Key objectives of IDEA ...
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16
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TERMINÉ
Novel Statistical Methodology for Diagnostic/Prognostic and Therapeutic Studies and Systematic Reviews (MEDIASRES)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
"Novel statistical methodology promises to greatly facilitate development of approaches for personalised medicine. While state-of-the-art statistical techniques have already advanced clinical trials and diagnostic/prognostic studies as the major source of evidence in clinical medicine, increasing availability of molecular techniques holds an even greater promise. However, for leveraging such infor ...
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10
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TERMINÉ
European Research Training in the Ubiquitin Proteasome System (UPStream)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
The main objective of the international training network UPStream is the training of a novel generation of European scientist in a critical and complex field of modern biology: the understanding of the regulation of the UPS and its potential use for drug development. The importance of this process is illustrated by the imperious necessity to destroy certain proteins during several phases of the ce ...
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10
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TERMINÉ
European Study to Establish Biomarkers of Human Ageing (MARK-AGE)
Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,
The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but in all cases their variab ...
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