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18 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Labor Market Risk and Skill Diversity: Implications for Efficiency, Policy, and Estimation (RISK AND DIVERSITY)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

Labor market risk and skill diversity are central features of the labor market. Arguably, employment risk is one of the biggest sources of uncertainty most individuals face in their life time. Likewise, exploiting the synergies and complementarities between differentially skilled workers is amongst the greatest challenges to firms' hiring decisions. The objective is to analyze the efficiency prope ...
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 2

 TERMINÉ 

The evolution of the human hand: grasping trees and tools (GRASP)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

The unique manipulative abilities of the human hand have fascinated scientists since the time of Darwin. However, we know little about how these unique abilities evolved because we have lacked, (1) the necessary fossil human (hominin) evidence and (2) the appropriate methods to investigate if, when and how our early ancestors used their hands for locomotion (climbing) and manipulation (tool-use). ...
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 3

 TERMINÉ 

Multi-country cOllaborative project on the rOle of Diet, FOod-related behaviour, and Obesity in the prevention of Depression (MooDFOOD) (MOODFOOD)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

MooDFOOD is a Multi-country cOllaborative project on the rOle of Diet, Food-related behaviour, and Obesity in the prevention of Depression. Depression is one of the most prevalent, severe and disabling disorders in the EU and places a heavy burden on individuals and families. A large proportion of the EU population is overweight which increases depression risk. Improving food-related behaviour and ...
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 17

 TERMINÉ 

Clonidine for Sedation of Paediatric Patients in the Intensive Care Unit (CloSed)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

The majority of critically ill children admitted to Paediatric Intensive Care Units (PICU) will require sedation and analgesia which is commonly achieved with a combination of an benzodiazepine and an opioid. However, these agents have a significant side-effect profile, including tolerance, withdrawal and respiratory/circulatory depression. Clonidine is commonly used for sedation in PICU and recom ...
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 10

 TERMINÉ 

Targets and biomarkers for antiepileptogenesis (EPITARGET)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Epilepsy is a devastating condition affecting over 50 million people worldwide. This multidisciplinary project is focused on the process leading to epilepsy, epileptogenesis, in adults. Our main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Our central premise and vision is that a comb ...
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 20

 TERMINÉ 

"Health and the Understanding of Metabolism, Aging and Nutrition" (HUMAN)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

"Recently intense research identified around 4,000 single nucleotide polymorphisms (SNPs) associated with human age related diseases such as metabolic disorders. Despite their highly significant association to pathology, the functional role of these genetic variants is, in most cases, yet to be elucidated. The evolutionary distance of most animal models from humans represents a major limitation fo ...
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 17

 TERMINÉ 

Targeting and exploiting B cell functions for treatment in cardiovascular disease (Athero-B-Cell)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

Cardiovascular disease (CVD) mortality and morbidity is predicted to increase in Europe and worldwide in the next decades due to aging and the rise of diabetes and obesity. The link between metabolic and inflammatory disease is getting stronger, raising hopes for novel therapeutic targets to be exploited clinically. Clinical evidence generated by the Academic partners of the Athero-B-Cell Consorti ...
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 11

 TERMINÉ 

Personalized diagnosis and treatment of hyperinsulinemic hypoglycaemia caused by beta-cell pathology (BETACURE)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2018,

Background:Hyperinsulinaemic hypoglycaemia (HH) is a potentially lethal disease caused by over functioning beta cells derived from the pancreatic islets of Langerhans. Lethal HH and brain damage is a problem especially in infants with congenital HH. Current therapeutic approaches are associated with severe side effects/morbidity (diabetes, exocrine pancreas insufficiency etc.) considered acceptabl ...
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 17

 TERMINÉ 

Tissue engineering of the right heart outflow tract by a biofunctionalized bioresorbable polymeric valved tube (TEH-TUBE)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

Approximately 42% of infants’ mortality in the world is related to congenital heart defects (prevalence: 8-12/1000 births). Over 1/3 require the reconstruction of the right ventricular outflow tract (RVOT) by surgical procedures which currently use inert materials without any growth potential. Consequently, multiple reoperations are often required, with their attendant high risk of mortality and m ...
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 7

 TERMINÉ 

Extracellular brain proteolysis in neuronal plasticity and neuropsychiatric disorders (EXTRABRAIN)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

Brain disorders comprise a major burden for the society. Recent analyses of the neuropsychiatric disease-related gene polymorphisms as well as genomics and proteomics have identified the components of the extracellular matrix (ECM) and the cell adhesion molecules (CAMs) in the brain as pivotal for those diseases. The ECM/CAMs span the synaptic cleft and regulate the synaptic dynamics. Furthermore, ...
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 9

 TERMINÉ 

Recognising Adverse Drug Reactions (WEB-RADR)

Date du début: 1 sept. 2014, Date de fin: 31 août 2017,

WEB-RADR is a consortium of leading experts in pharmacovigilance from regulatory agencies, research, academia and patient support groups. Together with EFPIA partners our aims will be to set policy & guidance and deliver robust information technology tools to address the potential for the reporting of adverse drug reactions (ADRs) through mobile applications and the recognition of drug safety sign ...
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 20

 TERMINÉ 

Geochemical Provenance Mapping of Pre-Roman Ironworking sites in Britain (IRONWORKS)

Date du début: 28 avr. 2014, Date de fin: 27 avr. 2016,

The IRONWORKS project combines innovative data analytic techniques with geochemical characterization methods to build a multi-element provenance database of smelting slag from primary iron production sites. This work will add a critical piece to the iron provenance puzzle, allowing researchers to realize the promise of advances in slag inclusion analysis and test a robust series of artefact sourc ...
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 1

 TERMINÉ 

Atlantic Late Bronze Age Interaction through Metal Hoards (ALBIMEH)

Date du début: 28 avr. 2014, Date de fin: 27 avr. 2016,

The aim of this project is to examine the nature and the degree of interaction between the Late Bronze Age communities of the European Atlantic façade (c. 1300-850 BC) through the study of metal hoards. We propose to determine the similarities and differences expressed by the hoards in different spheres (economic, technological, ideological and religious) by undertaking an intensive and comparativ ...
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 1

 TERMINÉ 

Preclinical studies in mouse hematopoietic stem cells for gene therapy of Wiskott-Aldrich Syndrome (WASHSCGENETHERAPY)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2016,

Wiskott-Aldrich Syndrome (WAS) is a primary X-linked rare disease (1:250.000 mainly children) caused by mutations in the was gene. Gene Therapy (GT) results in Primary Immunodeficiencies (PID) have been particularly successful due to advances in gene modification of hematopoietic stem cells (HSCs). Currently there is a clinical trial which has developed an ex vivo approach that uses a HIV-derived ...
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 1

 TERMINÉ 

Assembling a functional map of axonal signalling endosomes (AXOTRANSMAP)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2015,

The polarisation of neurons in somatodendritic and axonal compartments allows signal propagation over long distances. Despite the important role played by electrical signals, fast axonal transport is crucial for long-range communication between the soma and distal synapses, which is carried out by vesicular transport mechanisms. Neurotrophins and their receptors are internalised at axon terminals ...
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 1

 TERMINÉ 

Determination of the structure of the pathological neuroserpin polymer and development of an intrabody strategy to prevent disease-associated inclusions in cell and animal models of disease (Serpinopathies)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,

An increasing number of human disorders are recognised to result from the aggregation and tissue deposition of misfolded proteins. This group of diseases has been termed the conformational disorders and comprises such diseases as Alzheimer’s, Huntington’s and Parkinson’s disease as well as the amyloidoses and the serpinopathies. The serpinopathies are characterized by the polymerisation and tissue ...
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 2

 TERMINÉ 

Role of c-Myc in atherosclerotic macrophages (MycMacs)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2014,

Atherosclerosis and associated cardiovascular disease are the leading causes of mortality in developed countries and the World Health Organization has estimated that by 2020 these disorders will be the main sanitary and socio-economic problem world-wide due in part to the progressive aging of our societies. Atherosclerosis is a complex chronic inflammatory process triggered and perpetuated by card ...
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 2

 TERMINÉ 

Exiting long run poverty: the determinants of asset accumulation in developing countries (IHKDC)

Date du début: 1 juil. 2010, Date de fin: 31 déc. 2013,

We propose to study the determinants of the accumulation of productive assets among poor households in developing countries with a special, but not exclusive focus, on human capital. We plan to study how preferences, beliefs, information, expectations and available resources affect investment decisions, how these investment decisions are transformed in assets and how these assets can affect the ma ...
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 2