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20 projets européens trouvés

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 TERMINÉ 

Targeting SYNthetic lethal interactions for new cancer treatments TRAINing network (SYNTRAIN)

Date du début: 1 sept. 2016, Date de fin: 31 août 2020,

Breast and ovarian cancer constitute serious health challenges in the EU. To identify new improved cancer therapeutic approaches, we will pursue a multi-facetted synthetic lethal approach, which takes advantage of the inherent genetic instability of cancer cells. Most mutations acquired by cancer cells do not cause lethality, but the very same mutations may cause cell death when a second gene in a ...
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 10

 TERMINÉ 

Lysosomes as targets for cancer therapy (LYSOSOME)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"Knowing that the lysosomes contain a powerful cocktail of hydrolases capable of digesting cells and entire tissues, it is obvious that the maintenance of lysosomal membrane integrity is of utmost importance for all cells, and especially for cancer cells with dramatically increased lysosomal activity. Yet, the mechanisms that regulate lysosomal membrane stability have remained obscure, largely due ...
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 1

 TERMINÉ 

Exploiting MELanoma disease comPLEXity to address European research training needs in translational cancer systems biology and cancer systems medicine (MEL-PLEX)

Date du début: 1 déc. 2014, Date de fin: 30 nov. 2018,

Novel treatment options and associated personalised, patient-tailored therapies need to be explored and developed for highly heterogeneous and chemotherapy resistant cancers, such as malignant melanoma. This can only be achieved by industry-academia collaborations in newly emerging, innovative research disciplines such as translational cancer systems biology and systems medicine. These disciplines ...
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 11

 TERMINÉ 

Comparing health services interventions for the prevention of HPV-related cancer (COHEAHR)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Important progress has been made in the field of HPV-disease prevention with the development and implementation of HPV vaccines and HPV DNA screening. In the CoheaHr project, the (cost-) effectiveness of different European preventive strategies will be compared. The goal is to build a reliable and comparable evidence base on the (cost-) effectiveness of these policies implemented under country-spe ...
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 13

 TERMINÉ 

PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood (PANCARELIFE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and cause serious side-effects that can greatly impact survivors’ quality of life in the long term. The ...
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 19

 TERMINÉ 

Health consequences of noise exposure from road traffic (QUIET)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

There is growing public concern about adverse effects of traffic noise on health, as research has found that traffic noise increases the risk for cardiovascular diseases. Noise is thought to act as a stressor and disturbs sleep. Though this potentially could increase the risk for other major diseases, noise effects on other than the cardiovascular diseases are virtually unexplored.The main objecti ...
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 2

 TERMINÉ 

Epidemiological study to quantify risks for paediatric computerized tomography and to optimise doses (EPI-CT)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2017,

Diagnostic radiation represents an indispensable, sometimes life-saving, tool in modern medicine. However, the growing use of computerized tomography (CT) is a topic of concern in radiological protection, especially for children and adolescents. Children are generally more sensitive to the carcinogenic effects of ionizing radiation than adults. In addition, they have a longer life-span to express ...
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 22

 TERMINÉ 

A European Platform for Translational Cancer Research (EUROCANPLATFORM)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2016,

Europe has a number of advantages as regards developing translational cancer research, yet there is no clear European strategy to meet the increasing burden posed by cancer. The FP6 Eurocan+Plus project analysed the barriers underlying the increasing fragmentation of cancer research and stressed the need to improve collaboration between basic/preclinical and comprehensive cancer centres (CCCs), in ...
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 29

 TERMINÉ 

Epidemiological Studies of Exposed Southern Urals Populations (SOLO)

Date du début: 1 mars 2010, Date de fin: 28 févr. 2015,

This project aims to improve estimates of the risks of long-term health effects associated with protracted external and internal radiation exposures, through further studies of exposed populations in the Southern Urals (Russian Federation). Specific objectives of the project are as follows: 1. To develop improved modules for estimating external doses to exposed cohorts in the Southern Urals. It is ...
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 13

 TERMINÉ 

Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES)

Date du début: 1 févr. 2010, Date de fin: 31 janv. 2015,

CHANCES aims at combining and integrating on-going cohort studies in order to produce evidence on ageing-related health characteristics and determinants in Europe, and their socio-economic implications. 15 cohorts participate, covering populations from 18 EU Member States, 4 associate countries, and 3 additional countries. The combination of these different studies would lead to an integrated appr ...
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 17

 TERMINÉ 

The DNA damage response and breast cancer (DDRESPONSE)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,

We will exploit the DNA damage response (DDR) to assess and predict individual susceptibility and response focussed on breast cancer and breast cancer therapies. The 1st targeted therapy based on the DDR is inhibition of PARP by olaparib, which induces synthetic lethality in cancer cells with a specific DDR defect. Our members discovered olaparib, which is currently in Phase II trials. Its use in ...
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 6

 TERMINÉ 

Exploring ’synthetic lethality’ and ’synthetic viability’ to elucidate responses of breast and prostate cancer cells to DNA damage and treatment resistance (SYNvia)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2014,

The key objective of this Marie Curie project is to explore the ‘synthetic lethality’ and ‘synthetic viability’ principles applied to DNA damage response (DDR) mechanisms and help derive new therapies and/or biomarkers for personalized treatment of breast and prostate cancer. As these tumors are major causes of mortality and morbidity in Europe, and this multifaceted project in an outstanding host ...
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 1

 TERMINÉ 

Collaborative Oncological Gene-environment Study (COGS)

Date du début: 1 mai 2009, Date de fin: 31 janv. 2014,

The overarching goal of COGS is to identify individuals with an increased risk of breast, ovary and prostate cancer. Furthermore, we will evaluate the effect of inherited genetic variation on tumour characteristics and clinical outcome. We will do this through quantifying the role of genetic and environmental/lifestyle risk in the largest data set ever generated. In all, we will include over 200,0 ...
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 16

 TERMINÉ 

INTEGRATING ARMENIA INTO ERA (INARMERA)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2013,

"Integration of the South Caucasus countries into ERA is one of the priorities of EU’s European Neighbourhood Policy. This is the objective of ERAWIDE initiative aimed at reinforcing the cooperation capacity of a prominent R&D centre in these countries by providing the possibilities to improve its research activities in the areas of thematic priorities of FP7. The government of the Republic of Arm ...
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 3

 TERMINÉ 

European Study of Cohorts for Air Pollution Effects (ESCAPE)

Date du début: 1 juin 2008, Date de fin: 30 nov. 2012,

"European policy making is hampered by considerable uncertainty about the magnitude and nature of the impacts of long term exposure to air pollution on human health. ESCAPE is a collaboration of more than 30 European cohort studies including some 900,000 subjects. It is aimed at quantifying health impacts of air pollution and at reducing uncertainty. ESCAPE will also test new hypotheses on specifi ...
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 26

 TERMINÉ 

Europe against Cancer: Optimisation of the Use of Registries for Scientific Excellence in research (EUROCOURSE)

Date du début: 1 avr. 2009, Date de fin: 30 sept. 2012,

"EUROCOURSE will tackle fragmentation in the funding and usage of cancer registries in Europe. It will do so by exploring ways to link and integrate national/regional programmes aimed at supporting cancer registries and research carried out using registry data. At the same time EUROCOURSE is seeking to optimize the use of cancer registration data for the amelioration of cancer control and the stre ...
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 15

 TERMINÉ 

An integrated concept of tumor metastasis: implications for therapy (TuMIC)

Date du début: 1 avr. 2008, Date de fin: 31 mars 2012,

From many perspectives our concept of the process of metastasis is inadequate and needs to be revised. In particular, the potential impact of recent ideas about the cellular basis of tumor growth (cancer stem cells) and the establishment by remote tumors of special permissive microenvironments in target organs prior to metastasis (metastatic niches) remains to be explored. In the TuMIC project we ...
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 14

 TERMINÉ 

"Apoptosis systems biology applied to cancer and AIDS. An integrated approach of experimental biology, data mining, mathematical modelling, biostatistics, systems engineering and molecular medicine" (APO-SYS)

Date du début: 1 févr. 2008, Date de fin: 31 janv. 2012,

"A Europe-wide consortium of experimental biologists, biomathematicians, biostatisticians, computer scientists and clinical scientists will team up to approach cell death pathways in health and disease, placing particular emphasis on cancer and AIDS. The consortium will create a unique database integrating existing and accumulating knowledge on lethal signal transduction pathways leading to apopto ...
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 24

 TERMINÉ 

Genomic Instability in Cancer and Precancer (GENICA)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2010,

"Genomic instability is a characteristic of practically all human cancers. Recent results generated by members of this Consortium suggest that signs of genomic instability are evident from the very beginning of human cancer development, even in precancerous lesions. In these early lesions, the genomic instability affects primarily specific genomic loci, called common fragile sites. Because common ...
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 11

 TERMINÉ 

Prospective cohort studies of children with substantial medical diagnostic exposure (CHILD-MED-RAD)

Date du début: 1 sept. 2008, Date de fin: 30 nov. 2009,

The growing use of diagnostic X-rays and of high-dose techniques (CT, interventions) in children and adolescents is a topic of concern in radiological protection. Studies of other populations indicate that children are generally more sensitive to health effects of radiation than adults. In addition, children have a longer life-span to express any radiation-related health effect and, because of the ...
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 10