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 TERMINÉ 

Early-life stressors and LifeCycle health (LIFECYCLE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Early life is an important window of opportunity to improve health across the full lifecycle. European pregnancy and child cohort studies together offer an unique opportunity to identify a wide range of early life stressors linked with individual biological, developmental and health trajectory variations, and to the onset and evolution of non-communicable diseases. LIFECYCLE will establish the Eur ...
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 19

 TERMINÉ 

Reaching the effects of gastric bypass on diabetes and obesity without surgery (BYPASSWITHOUTSURGERY)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Gastric bypass surgery results in massive weight loss and diabetes remission. The effect is superior to intensive medical treatment, showing that there are mechanisms within the body that can cure diabetes and obesity. Revealing the nature of these mechanisms could lead to new, cost-efficient, similarly effective, non-invasive treatments of these conditions. The hypothesis is that hyper-secretion ...
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 2

 TERMINÉ 

Mechanism of DNA-protein cross-link repair in S phase (DPC_REPAIR)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

DNA-protein cross-links (DPCs) are common DNA lesions caused by endogenous, environmental, and chemotherapeutic agents. Cells are susceptible to these lesions during S phase, as DPCs impede replication fork progression and are likely to induce genomic instability, a cause of cancer and aging. Despite its relevance to human health, the repair of DPCs is poorly understood. Research on DPC repair has ...
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 1

 TERMINÉ 

An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century (EU-ToxRisk)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2021,

The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemi ...
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 43

 TERMINÉ 

GALAXY: Gut-and-liver axis in alcoholic liver fibrosis (GALAXY)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2021,

Alcohol overuse is an important societal challenge with annual healthcare costs of over €22 billion in Europe. Alcohol is the main cause of liver cirrhosis, which is the 5th and 7th most common cause of life years lost in respectively Eastern and Western Europe. Cirrhosis is considered irreversible but its precursor, liver fibrosis, is reversible when detected before disease progression. GALAXY pr ...
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 12

 TERMINÉ 

The makeup of the modern horse: a history of the biological changes introduced by human management (PEGASUS)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2021,

The horse provided us with rapid transportation, an almost unrivaled secondary product that tremendously impacted the politico-economical trajectory of our societies, revolutionizing the circulation of ideas, people, languages, religions and communication. Horse chariotry and cavalry also changed warfare and beyond the battlefield new equestrian technologies have stimulated agricultural productivi ...
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 2

 TERMINÉ 

From Fermi to Planck : a bottom up approach (NuBSM)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

The Standard Model of particle physics is a hugely successful theory that has been tested in experiments at ever increasing energies, culminating in the recent discovery of the Higgs boson. Nevertheless, some major riddles cannot be addressed by the Standard Model, such as neutrino oscillations, the existence of Dark Matter, the absence of antimatter in the Universe. New fundamental principles, in ...
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 3

 TERMINÉ 

Matrix during cancer progression (MATRICAN)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

The extracellular matrix (ECM) is known to play a critical role in driving cancer progression, and yet we lack knowledge of its composition and structure. The goal of my ERC project is to investigate how alterations in biochemical composition and structural properties of the ECM during cancer progression impact on cell behaviour to drive metastasis, which is responsible for over 90% of cancer pati ...
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 1

 TERMINÉ 

Northern Europe's timber resource - chronology, origin and exploitation (TIMBER)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

Empirical evidence for the history of the exploitation of the timber resource in Northern Europe is stored in the material record. Archaeological finds, art-historical objects and built heritage have provided us with an extensive dataset of precisely dated wood from heritage contexts. This material is the key to details about the usage, condition and availability of the timber resource and details ...
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 1

 TERMINÉ 

Foetal Intestinal Stem Cells in Biology and Health (StemHealth)

Date du début: 1 août 2016, Date de fin: 31 juil. 2021,

There is currently no medical cure for the millions of individuals affected by inflammatory bowel disease (IBD). These patients suffer from bleeding along the gastrointestinal tract due to epithelial ulceration, which causes severe abdominal pain, diarrhoea and malnutrition. This is due to the severely compromised integrity of the intestinal epithelium. I propose that patients with IBD will benefi ...
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 1

 TERMINÉ 

Dissecting the constraints that define the eukaryotic DNA replication program (REPLICONSTRAINTS)

Date du début: 1 août 2016, Date de fin: 31 juil. 2021,

DNA replication is essential for the perpetuation of life and, yet, it is also a major source of genomic instability that can lead to cancer and other human diseases. Despite the vast efforts invested in establishing the origins of genomic instability, the mechanisms that coordinate faithful genome duplication while ensuring its integrity remain unknown.This dilemma is molecularly best exemplified ...
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 1

 TERMINÉ 

Mumps VIRus EXploitation of the human adhesion receptor GPR125 (VIREX)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

Mumps virus is a re-emerging pathogen that causes painful inflammatory symptoms, such as parotitis (salivary gland infection) and orchitis (testis infection). It is highly neurotropic with evidence of brain infection in half of cases and clinical evidence in up to 10%. It is a small RNA virus belonging to the family of paramyxoviridae that includes e.g. viruses for measles and pneumonia, all havin ...
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 1

 TERMINÉ 

Policy, practice and patient experience in the age of intensified data sourcing (POLICYAID)

Date du début: 1 juin 2016, Date de fin: 31 mai 2021,

The European healthcare services have begun collecting tissue samples and healthcare data from patients on an unprecedented scale. With POLICYAID we suggest the term 'intensified data sourcing' to describe these attempts at getting more data, on more people, of better quality while simultaneously making the data available for multiple uses. Data are used for research, for financial remuneration pu ...
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 1

 TERMINÉ 

Chromosomal Common Fragile Sites: Unravelling their biological functions and the basis of their instability (CFS modelling)

Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,

Cancer and other diseases are driven by genomic alterations initiated by DNA breaks. Within our genomes, some regions are particularly prone to breakage, and these are known as common fragile sites (CFSs). CFSs are present in every person and are frequently sites of oncogenic chromosomal rearrangements. Intriguingly, despite their fragility, many CFSs are well conserved through evolution, suggesti ...
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 1

 TERMINÉ 

Diplomatic Face-Work - between confidential negotiations and public display (DIPLOFACE)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,

The rise of social media, coupled with intensifying demands for more transparency and democracy in world politics, brings new challenges to international diplomacy. State leaders and diplomats continue to react to traditional media, but now also attempt to present themselves proactively through tweets, public diplomacy and nation branding. These efforts often take place simultaneously and sometime ...
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 2

 TERMINÉ 

Exploring and exploiting the potential of extinct genome sequencing (Extinction Genomics)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,

Palaeogenomics is the nascent discipline concerned with sequencing and analysis of genome-scale information from historic, ancient, and even extinct samples. While once inconceivable due to the challenges of DNA damage, contamination, and the technical limitations of PCR-based Sanger sequencing, following the dawn of the second-generation sequencing revolution, it has rapidly become a reality. Ind ...
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 1

 TERMINÉ 

The Genus Haslea, New marine resources for blue biotechnology and Aquaculture (GHaNA)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2021,

The GHaNA project aims to explore and characterize a new marine bioresource, for blue biotechnology applications in aquaculture, cosmetics and possibly food and health industry. The project will determine the biological and chemical diversity of Haslea diatoms to develop mass-scale production for viable industrial applications by maximising biomass production and associated high-value compound pro ...
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 11

 TERMINÉ 

Teaching Emerging Methods in Palaeoproteomics for the European Research Area (TEMPERA)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2021,

TEMPERA will provide international, intersectoral and interdisciplinary state-of-the-art doctoral training to prepare the next generation of specialists in mass spectrometry-based ancient protein residues analysis for biomolecular diagnostics and conservation of cultural heritage material.Due to their chemical and mechanical properties, proteins have always represented the category of biomolecules ...
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 6

 TERMINÉ 

Probing topology and dynamics in driven quantum many-body systems (TopDyn)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

If the twentieth century was about discovering the basic laws of quantum mechanics, then the twenty first century will be about pushing them to new frontiers and learning how to control them. Condensed matter systems are predicted to host many intriguing and potentially useful quantum phenomena, though materials where they can be realized are rare. This motivates me to seek alternative routes for ...
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 1

 TERMINÉ 

Innovative Nanowire DEvicE Design (INDEED)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2021,

Nanowires (NWs) exhibit unique properties that make them potential building blocks for a variety of next generation NanoElectronics devices. Recent advances have shown that NWs with predefined properties can be grown, offering a new paradigm enabling functional device prototypes including: biosensors, solar cells, transistors, quantum light sources and lasers. The critical mass of scientific knowl ...
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 12

 TERMINÉ 

Optical Infrared Coordination Network for Astronomy (OPTICON)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Europe has become a global leader in optical-near infrared astronomy through excellence in space and ground-based experimental and theoretical research. While the major infrastructures are delivered through major national and multi-national agencies (ESO, ESA) their continuing scientific competitiveness requires a strong community of scientists and technologists distributed across Europe’s nations ...
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 34

 TERMINÉ 

Towards enduring mouse resources and services advancing research into human health and disease (INFRAFRONTIER2020)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st ...
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 33

 TERMINÉ 

Quantum Information Access and Retrieval Theory (QUARTZ)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Quantum Information Access and Retrieval TheoryWe aim to establish an European Training Network (ETN) on QUantum information Access and Retrieval Theory (QUARTZ). Towards a new approach to Information Access and Retrieval (IAR) addressing the challenges of the dynamic and multimodal nature of the data and user interaction context, QUARTZ aims to educate its Early Stage Researchers (ESRs) to adopt ...
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 7

 TERMINÉ 

Hybrid Optomechanical Technologies (HOT)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The hybrid optomechanical technologies (HOT) consortium will lay the foundation for a new generation of devices, which connect, or indeed contain, several platforms at the nanoscale in a single “hybrid” system. As hybrid interfaces they will allow to harness the unique advantages of each subsystem within a nano-scale footprint, while as integrated hybrid devices they will enable entirely novel fun ...
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 17

 TERMINÉ 

European training Network for In situ imaGing of dynaMic processes in heterogeneous subsurfAce environments (ENIGMA)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The ENIGMA network will train a new generation of young researchers in the development of innovative sensors, field survey techniques and inverse modelling approaches. This will enhance our ability to understand and monitor dynamic subsurface processes that are key to the protection and sustainable use of water resources. ENIGMA focuses mainly on critical zone observation, but the anticipated tech ...
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 11

 TERMINÉ 

Small vessel diseases in a mechanistic perspective: Targets for InterventionAffected pathways and mechanistic exploitation for prevention of stroke and dementia (SVDs-at-target)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Stroke and dementia rank among the most pressing health issues in Europe. Cerebral small vessel diseases (SVDs) have emerged as a central link between these two major co-morbidities. SVDs account for more than 30% of strokes and at least 40% of dementia cases. They encounter multiple distinct diseases that can be separated based on their underlying genetic defects, risk factors, and clinical prese ...
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 14

 TERMINÉ 

European Academy for Biomedical Science (ENABLE)

Date du début: 1 juil. 2016, Date de fin: 31 déc. 2020,

The proposed European Academy for Biomedical Science (ENABLE) consortium will connect aspiring European researchers of tomorrow with prominent scientists of today, in particular to inspire and to give them the necessary tools to follow in their footsteps. ENABLE will organize peer-reviewed symposia celebrating European life science achievements from molecule to man/patient. These symposia will hav ...
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 6

 TERMINÉ 

INtestinal Tissue ENgineering Solution (INTENS)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Short Bowel Syndrome (SBS) is a condition that occurs when part or the entire small intestine is missing or has been removed during surgery. This condition renders the bowel incapable of fulfilling its nutritional function (intestinal failure). There is no cure for SBS. Parenteral (intravenous) nutrition (PN) and bowel transplantation are currently the preferred options for nutrition in children a ...
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 9

 TERMINÉ 

Natural Toxins and Drinking Water Quality - From Source to Tap (NaToxAq)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Clean drinking water is crucial to human health and wellbeing. The ambition of the NaToxAq ETN network is to expand the research basis for EU’s leading role in securing high quality drinking waters for its citizens. Focus is on natural toxins – a large group of emerging contaminants with unknown impact on drinking water resources. Both known toxins, like cyanotoxins, cyanogenic glucosides and terp ...
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 10

 TERMINÉ 

Integrated inter-sector framework to increase the thermal resilience of European workers in the context of global warming (HEAT-SHIELD)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Environmental heating is a growing challenge for our community and problems are already experienced by millions of Europeans during the summertime and aggravated during heat waves or occupational settings. In addition to the well-known health risks related to severe heat stress, a number of studies have confirmed significant loss of productivity due to hyperthermia. Even if countries adopt the EU ...
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 21

 TERMINÉ 

State Formation Through the Local Production of Property and Citizenship (Local State)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

The key concern of the proposed research is how political power is established and reproduced through the production of the fundamental social contracts of property and citizenship. We will re-define the research on so-called failed and weak states, by examining what political authority is actually exercised rather than measuring how they fall short of theoretical ideals. In developing countries w ...
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 1

 TERMINÉ 

“In Vivo Click PET Imaging Agents”: Improving clinical companion diagnostics (Click-It)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Companion diagnostics are crucial for drug development and disease management with regard to patient selection, therapy planning and monitoring. Nanomedicines such as antibodies have been proven to be optimal disease-targeting agents because they generally exhibit superior target uptake and retention. However, to date, nuclear imaging of nanomedicines has been limited to the use of long-lived isot ...
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 6

 TERMINÉ 

Scalable Quantum Photonic Networks (SCALE)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2020,

It is an outstanding challenge in quantum physics of today to scale small proof-of-concept experimental demonstrations into larger quantum networks. In the last decade, solid-state photonic systems have matured significantly, and an ambitious research project on such scaling seems viable. With the present proposal we intend to take up this challenge and exploit single quantum dots in photonic-crys ...
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 1

 TERMINÉ 

Doctoral Industrial School for Vaccine Design through Structural Mass Spectrometry (VADEMA)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

Vaccines discovered from empirical approaches and consisting in killed, live-attenuated microorganisms or purified components have led to the successful control of many devastating diseases. Several novel technologies, such as recombinant DNA technology, glycoconjugation, reverse vaccinology have opened the possibility of designing vaccines previously considered impossible to make. Despite decades ...
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 2

 TERMINÉ 

Smart capture phases for proteomics, glycomics and biomarker assays (BioCapture)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

The overall objective of BioCapture is to develop novel robust assays for proteinaceous biomarkers associated with cancer and to develop innovative tools for assaying elusive cancer related posttranslational modifications in proteins. This will be achieved by exploiting robust glycan, peptide and protein binders in the form of Molecularly Imprinted Polymers (MIPs) or plastic antibodies alongside g ...
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 8

 TERMINÉ 

Systematic Decoding of Deubiquitylase-Regulated Signaling Networks (DUB-DECODE)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2020,

Cellular processes are largely governed by sophisticated protein posttranslational modification (PTM)-dependent signaling networks, and a systematic understanding of regulatory PTM-based networks is a key goal in modern biology. Ubiquitin is a small, evolutionarily conserved signaling protein that acts as a PTM after being covalently conjugated to other proteins. Reversible ubiquitylation forms th ...
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 1

 TERMINÉ 

OMT - Optomechanical Technologies (OMT)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,

The proposed project is built on the successful training and research experience of the leading European research groups working in the field of cavity optomechanics. Our ENT unites a total of 14 leading groups in the field, of which two are major industrial players that utilize MEMS and NEMS - Bosch and IBM. The main goal of the project is to exploit optomechanical interactions in views of novel ...
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 14

 TERMINÉ 

Trust, Global Traders, and Commodities in a Chinese International City (TRODITIES)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2020,

Trust, Global Traders, and Commodities in a Chinese International CityYiwu, a city of 2 million in China’s commercially vibrant Zheijang province, is known by traders from countries including Afghanistan and Syria, the Ukraine and Mexico, and the UK and Russia, as being the world’s hub for wholesale of ‘small commodities’. Journalists have recently been struck both by Yiwu’s significance to consu ...
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 4

 TERMINÉ 

Techniques and Technologies for Effective Wood Procurement (TECH4EFFECT)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2020,

The project focuses on increasing access to wood resources through more efficient silviculture and a better understanding of the business models governing the procurement of forest operations services. The project further considers increasing efficiency in forest harvesting and collection, and the reduction of soil impact from forest operations, and puts forward ways of making this a measurable an ...
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 19

 TERMINÉ 

Connecting the Extreme (ConTExt)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Advances in technology and methodology over the last decade, have enabled the study of galaxies to the highest redshifts. This has revolutionized our understanding of the origin and evolution of galaxies. I have played a central role in this revolution, by discovering that at z=2, when the universe was only 3 Gyr old, half of the most massive galaxies were extremely compact and had already complet ...
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 1