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21 projets européens trouvés

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 TERMINÉ 

Combatting Bacterial Resistance in Europe - Carbapenem Resistance (COMBACTE-CARE)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2020,

Multi-drug resistant Gram-negative bacteria (MDR-GNB): the ultimate challenge!Antibiotic resistance is a global public health concern recently elevated to the top three threats identified by the WHO, and subject of numerous national and international government activities. Although focused strategies have beneficially influenced infection rates due to methicillin resistant Staphylococcus aureus (M ...
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 23

 TERMINÉ 

European Clinical Research Infrastructures Network - Integrating Activity (ECRIN-IA)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,

ECRIN is a distributed ESFRI-roadmap pan-European infrastructure designed to support multinational clinical research, making Europe a single area for clinical studies, taking advantage of its population size to access patients. Servicing multinational trials started during its preparatory phase, and it now applies for an ERIC status by 2011. The ERIC budget will be restricted to core activities re ...
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 48

 TERMINÉ 

EUROPEAN FORENSIC GENETICS Network of Excellence (EUROFORGEN-NOE)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

The EUROFORGEN-NoE proposal aims to develop a network of excellence for the creation of a European Virtual Centre of Forensic Genetic Research. Forensic genetics is a highly innovative field of applied science with a strong impact on the security of citizens. However, the genetic methods to identify offenders as well as the creation of national DNA databases have caused concerns to the possible vi ...
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 19

 TERMINÉ 

European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2015,

The aim of EU-GEI is to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia (EU-GEI, Schiz. Res. 2008; 102: 21-6). In order to identify these interactive determinants, EU-GEI will employ family-based, multidisciplinary research paradigms, which allow for the efficient assessment of gene-environment interaction ...
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 27

 TERMINÉ 

Development of a novel FGL therapy and translational tests for regenerative treatment of neurological disorders (NEUROFGL)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

Neurodegenerative disorders such as, Alzheimer’s disease (AD), Mild Cognitive Impairment (MCI), stroke, Traumatic Brain Injury (TBI) and chronic stress create a major economic burden to society and a substantial reduction in quality of life for patients and families. The development of neuroregenerative therapies is notoriously difficult and requires significant investment. NeuroFGL will contribut ...
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 7

 TERMINÉ 

Data Infrastructure for Chemical Safety (diXa)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2014,

The EU nowadays witnesses increasing demands with regard to chemical safety. In particular, animal-based test models need to be replaced preferably by robust, non-animal assays in vitro/in silico which better predict human toxicity in vivo, are less costly, and are socially better acceptable. Consumer's and patient's health will benefit and competitiveness of EU's chemical manufacturing industry w ...
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 7

 TERMINÉ 

Determining (epi)genetic therapeutic signatures for improving lung cancer prognosis (CURELUNG)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2014,

"Lung cancer (LC) is still the most lethal type of cancer worldwide. The extremely poor prognosis for LC patients is partly due to the lack of effective therapies. At present, most patients with pulmonary carcinomas are treated with chemotherapy. This essentially consists of classic cytotoxic drugs which only improve survival in small cohorts in few cases. In spite of the rapidly growing understan ...
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 11

 TERMINÉ 

Host and viral factors in acute hepatitis C (HEPACUTE)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2014,

Chronic hepatitis C is one of the most common chronic viral infections of humans and a major cause of chronic liver disease, cirrhosis and liver cancer. Still about 4 million new infections occur world-wide each year with 50-85% of patients progressing to chronic hepatitis C. Currently there is no marker to predict spontaneous viral clearance and to guide treatment decisions.The major objectives o ...
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 17

 TERMINÉ 

Embryonic Stem cell-based Novel Alternative Testing Strategies (ESNATS)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,

"ESNATS aims at developing a novel toxicity test platform based on embryonic stem cells (ESC), especially human ESC (hESC), to accelerate drug development, reduce R&D costs and propose a powerful alternative to animal tests (3 Rs). ESNATS will address current drug-testing shortcomings: - testing takes place late in the development cycle - animal test systems bear the risk of non-prediction due to ...
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 34

 TERMINÉ 

European Obesity Consortium studying the Hypothalamus and its Interaction with Peripheral organs (EurOCHIP)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

The past decade has seen tremendous progress in our understanding of homeostatic regulators controlling energy balance. Insights from human and murine genetics have illuminated multiples pathways within the hypothalamus, brainstem and higher brain regions that play a key role in the control of food intake, whilst physiological studies focusing on the gastrointestinal tract have revealed a panoply ...
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 10

 TERMINÉ 

"Reinforcement of the Adult stem cell research are through Mobility and Scientific networking between Egypt, Romania and a German consortium for Strengthening the international scientific competency" (RAMSES)

Date du début: 1 mars 2010, Date de fin: 31 août 2013,

"INTRODUCTION. RAMSES comprises partner institutions from Germany (FMC), Romania (ICBP) and Egypt (CU) in order to promote closer S&T cooperation opportunities between Europe and Egypt. The concept of RAMSES is to build capacities by improving scientific relationships, networking and development of the S&T Human Potential, exchanging of know-how and experience between the participating partners, a ...
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 4

 TERMINÉ 

Angiogenesis-inducing Bioactive and Bioresponsive Scaffolds in Tissue Enginering (AngioScaff)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2012,

Angiogenesis underlies almost all biological processes of morphogenesis, including those in tissue repair and regeneration. Physiological angiogenesis is controlled by a complex interplay between cells and their environment: the extracellular matrix (ECM) provides signaling via numerous ECM adhesion molecules and growth factors bound to ECM polysaccharide components; and cells locally degrade and ...
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 33

 TERMINÉ 

High yield and performance stem cell lab (Hyperlab)

Date du début: 1 sept. 2009, Date de fin: 31 août 2012,

The success of stem cell therapy is highly dependent on a safe and reliable supply of human stem cells and stem cell-derived differentiated cells, which must be assured by efficient and robust culture methods. Current culture of human embryonic and adult stem cells is not optimised (with regards to e.g. media, growth factors, supporting biomaterials, differentiation techniques) and is far from ful ...
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 9

 TERMINÉ 

Therapy after heart infarct: prevention of reperfusion injury and repair by stem cell transfer (Infarct Cell Therapy)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2012,

A key problem in repair and functional regeneration following myocardial infarction is the inability of heart muscle tissue to regenerate itself and appropriate vascularization under conditions of increased strain caused by the reduced contractibility of the damaged heart. This frequently leads to continuous loss of functional cells, further increase of the infarct area and finally complete loss o ...
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 9

 TERMINÉ 

ASSESSMENT OF HEARING IN THE ELDERLY: AGING AND DEGENERATION - INTEGRATION THROUGH IMMEDIATE INTERVENTION (AHEAD III)

Date du début: 1 mai 2008, Date de fin: 31 oct. 2011,

"Hearing loss is one of the most common chronic health conditions in the elderly population with important implications for patient quality of life. The diminished ability to hear and to communicate is frustrating in and of itself, but the strong association of hearing loss with depression and functional decline adds further to the burden on individuals who are hearing impaired. Hearing loss can ...
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 19

 TERMINÉ 

Genetic Analysis of the host-pathogen interaction in tuberculosis (TB-EURO-GEN)

Date du début: 1 mars 2008, Date de fin: 31 août 2011,

"We propose to extend an existing collection of DNA extracts from TB patients and their corresponding TB DNA to establish the world’s largest resource of extracts from a population of TB patients and 5000 ethnically matched healthly controls. The bank will comprise 5000 DNA host DNA extracts paired the DNA and cultures of the strain of Mycobacterium tuberculosis causing their disease. We will pe ...
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 5

 TERMINÉ 

Development and analysis of polymer based multi-functional bactericidal materials (EMBEK1)

Date du début: 1 août 2008, Date de fin: 31 juil. 2011,

90% of bacteria are found attached to solid surfaces forming structures (bio-films), that are inaccessible to drugs and antibiotics. These bio-films represent a major problem in European society in both industry and health care. Currently, however, we understand little about how these bio-films form and, more importantly, how they can be prevented. This lack of understanding means that patients of ...
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 11

 TERMINÉ 

An Investigation into Tolerance Induction by Extracorporeal Phototherapy (ECP Tolerance)

Date du début: 1 juil. 2008, Date de fin: 30 juin 2011,

Allogeneic haematopoietic stem cell transplantation (HSCT) is an important curative therapy for a large number of hematological diseases. Graft versus host disease (GVHD) remains the major complication of allogeneic HSCT, which occurs in 40-60% of transplant recipients and could be directly responsible for 25% of transplant related mortality and a significant proportion of transplant related morbi ...
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 1

 TERMINÉ 

European IPF Network: Natural course, Pathomechanisms and Novel Treatment Options in Idiopathic Pulmonary Fibrosis (eurIPFnet)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2011,

In the eurIPFnet consortium, leading European basic and clinical scientists in the field of interstitial lung diseases associate to jointly decipher the natural course and molecular pathomechanisms of Idiopathic Pulmonary Fibrosis (IPF) and to develop new therapeutic strategies for patients with IPF. This devastating disease affects about 360.000 patients in the EU and causes a substantial socioec ...
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 13

 TERMINÉ 

Discovery of novel cancer serum biomarkers based on aberrant post translational modifications of O-glycoproteins (O-PTM-Biomarkers) and their application to early detection of cancer (O-PTM-Biomarkers)

Date du début: 1 janv. 2008, Date de fin: 31 mars 2011,

Early detection accomplished through an efficient screening programme remains the most promising approach to improve the long-term survival of cancer patients. Therefore there is a pressing need for the development of biomarkers, which detect the early changes for cancers where clinical symptoms only appear when the cancer has progressed, and treatment is ineffective. Our proposal, which addresses ...
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 9

 TERMINÉ 

A European Collaboration to optimise research for the care of cancer patients in the last days of life (OPCARE9)

Date du début: 1 mars 2008, Date de fin: 31 mars 2011,

"The project aims to explore, share and collate existing knowledge and practice in each of the key themes identified within the work programme. It aims to reach consensus (based on current practice and available research evidence) on the optimum care to be delivered in the last days of life and gaps in the knowledge base. In addition, it aims to develop innovative ways of addressing gaps in knowle ...
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 9