3 projets européens trouvés
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TERMINÉ
Tumour Heterogeneity and Somatic Evolution of Unstable cancer genomes (THESEUS)
Date du début: 1 juin 2014, Date de fin: 31 mai 2019,
SummaryThe majority of metastastic solid tumours remain incurable. In-depth analysis of tumour genomes is revealing evidence for branched evolution and cancer subclonal spatial and temporal intratumour heterogeneity (ITH). Drivers of ITH such as chromosomal instability (CIN) are associated with drug resistance and poor clinical outcome. However, despite increasing knowledge of tumour diversity, th ...
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3
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TERMINÉ
Mapping the Targets of Antimalarial Compounds Through Chemical Profiling (MALARIA TARGETS ID)
Date du début: 1 sept. 2014, Date de fin: 31 août 2018,
Malaria is one of the most devastating infectious diseases affecting half of the world population and killing close to a million people every year. Widespread resistance of the malaria parasite to most front-line drugs and the rapid emergence of resistance against new therapies have made the validation of novel pharmaceutical targets and the identification of potent pharmacophores extremely urgent ...
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2
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TERMINÉ
The impact of chromosomal instability on health: Molecular causes and consequences of aneuploidy (PLOIDYNET)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
Aneuploidy, an abnormal number of chromosomes, is a hallmark of cancer cells, affecting the majority of all human tumours. Aneuploidy arises when errors occur during mitosis, as the duplicated chromosomes are distributed between the two new daughter cells. Paradoxically, aneuploidy appears to have detrimental consequences for the physiology of untransformed cells in vitro, inhibiting rather than s ...
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