4 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Chromatin and MetabolismChromatin-metabolism interactions as targets for healthy living (ChroMe)
Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,
Metabolic disorders are at pandemic levels. Based on recent estimates, ~50% of Europeans are overweight, 20% are obese and 10% have type II diabetes. Obesity and insulin resistance impact European health to the tune of €110 billion per year. These disorders have genetic, nutritional and lifestyle causes. However, the molecular mechanisms that link nutrients and lifestyle to gene activity and chrom ...
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12
Participants partenaires
TERMINÉ
Cell of origin/Leukemia Initiating Cell in infant Pro-B MLL-AF4+ ALL (MODELING MLL-AF4 ALL)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,
"Infant pro-B acute lymphoblastic leukemia (ALL) carrying the fusion oncogene MLL-AF4 is associated with very brief latency and dismal prognosis. Recent studies have revealed an in utero origin of MLL-AF4 but the nature of the target cell for transformation in the embryo/fetus is unknown. Because of the mixed phenotype and the presence of MLL-AF4 in both lymphoid and myeloid lineages, hematopoieti ...
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1
Participant partenaire
TERMINÉ
Human-centric Intelligent LED engines for the take up of SSL in Europe (HI-LED)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2016,
The HILED project will advance the state of the art of Solid State Lighting (SSL) through research on innovative light engines that take advantage of full control of light. The incorporated intelligence enables responsive fine tuning of spectral properties in real time, as well as precise dimming capabilities. These smart engines with added intelligence offer natural illumination patterns that res ...
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9
Participants partenaires
TERMINÉ
GENOMIC, CELLULAR AND DEVELOPMENTAL RECONSTRUCTION OFINFANT MLL-AF4+ ACUTE LYMPHOBLASTIC LEUKEMIA (INFANTLEUKEMIA)
Date de fin: 1 janv. 2016,
Infant cancer is very distinct to adult cancer and it is progressively seen as a developmental disease. An intriguing infant cancer is the t(4;11) acute lymphoblastic leukemia (ALL) characterized by the hallmark rearrangement MLL-AF4 (MA4), and associated with dismal prognosis. The 100% concordance in twins and its prenatal onset suggest an extremely rapid disease progression. Many key issues rema ...
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