6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Regulation of gene expression and cell fate by DNA (hydroxy)methylation (HeavyMethyl)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
(Hydroxy)methylation of cytosine residues in eukaryotic DNA represents a major means to regulate gene expression during development. These modifications are considered to be epigenetic marks, since they have a profound impact on phenotype, but are inherited from mother to daughter cells independent of the underlying DNA sequence. Large efforts are currently underway to profile genome-wide DNA (hyd ...
Voir le projet
2
Participants partenaires
TERMINÉ
Industry-Academia exchange to further FXR-based therapeutic intervention and non-invasive diagnosis in Inflammatory Bowel Disease (FXR-IBD)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,
Inflammatory Bowel Disease (IBD) covers a cluster of disorders characterized by chronic intestinal inflammation which affects approximately 0.2% of the global human population. Current treatment options often fail, are marred by side-effects and undergoing regular endoscopy to monitor and manage the disease is often a burden to the patient.In this study we aim to:1. Develop a novel treatment for I ...
Voir le projet
3
Participants partenaires
TERMINÉ
European Consortium for High-Throughput Research in Rare Kidney Diseases (EURENOMICS)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,
EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts asse ...
Voir le projet
29
Participants partenaires
TERMINÉ
WNT-mediated signal relay in stem cells and oncogenesis - from basic biology to applications (WntsApp)
Date du début: 1 août 2013, Date de fin: 31 juil. 2017,
The ITN WntsApp is organized to achieve 3 key aims: (i) Provide a committed training programme for young researchers to bridge the gap between basic scientific knowledge and drug development, (ii) Centring research on a key cancer-signalling pathway, WNT signalling, to stimulate synergies and (iii) Strengthening the link between international partners and private enterprises to stimulate innovatio ...
Voir le projet
10
Participants partenaires
TERMINÉ
TOwards Personalized medicine: defining the role of the bone marrow microenvironment in multiple myeloma (TOP)
Date du début: 17 sept. 2012, Date de fin: 16 sept. 2015,
Multiple myeloma (MM), the second most common hematological malignancies, is characterized by an expansion of malignant plasma cells (PCs) in the bone marrow (BM). Despite the development of novel therapies, MM remains an incurable disease with a 5-7 year survival expectancy. MM is usually proceeded by an asymptomatic premalignant state of clonal PC expansion, i.e. MGUS. Progression of MGUS to MM ...
Voir le projet
1
Participant partenaire
TERMINÉ
STEM-TECH: Introducing proprietary stem cell marker technology for the life sciences market (STEM-TECH)
Date du début: 1 févr. 2013, Date de fin: 31 juil. 2014,
STEM-TECH has been designed to investigate the commercial opportunity for exploiting our patented stem cell marker technology in the life sciences market. This proprietary technology will meet the need for new enabling technologies that unlock the potential of stem cell detection in academic, industrial and clinical research and practice.THE OPPORTUNITYThe stem cell market is a relatively immature ...
Voir le projet