9 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
European Friedreich's Ataxia Consortium for Translational Studies (EFACTS)
Date du début: 1 mai 2010, Date de fin: 30 avr. 2015,
EFACTS (the European Friedreich’s Ataxia Consortium for Translational Studies) assembles a body of expertise to adopt a translational research strategy for the rare autosomal recessive neurological disease, Friedreich’s ataxia (FRDA). FRDA is a severely debilitating disease that leads to loss of the ability to walk and dependency for all activities. Some patients have cardiomyopathy that can cause ...
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15
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TERMINÉ
Systems biology of Mycobacterium tuberculosis (SYSTEMTB)
Date du début: 1 avr. 2010, Date de fin: 30 sept. 2014,
Tuberculosis (TB) is a re-emerging global health threat caused by Mycobacterium tuberculosis (Mtb). One third of the world's population is infected with Mtb and new infections occur at a rate of one per second. Despite global research efforts, mechanisms underlying pathogenesis, virulence and persistence of Mtb infection remain poorly understood. Simple reductionist approaches are insufficient to ...
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14
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TERMINÉ
miRNASTRESS: structural and functional study of the RBM38-controlled mechanism of mRNA stabilization (miRNASTRESS)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2014,
The aim of the research activities detailed in this proposal is to understand how the RNA-binding protein RBM38 mediates the cellular stress response —the series of cellular events triggered by diverse harmful factors to restore cellular homeostasis— by modulating the activity of microRNAs on specific targets. Our objective is to determine the molecular mechanism by which RBM38 interferes with th ...
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1
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TERMINÉ
Orchestration of instinctive drives (INSTINCTIVE DRIVES)
Date du début: 1 oct. 2008, Date de fin: 30 sept. 2013,
A major goal of 21st century science is to protect human health from the growing mismatch between ancient behavioural instincts and modern socio-economic reality. This is especially vital for basic instinctive drives such as appetite, which lead to overeating when food is readily available. The resulting obesity is responsible for 100,000s of premature deaths per year in Europe and North America, ...
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2
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TERMINÉ
Evolution of gene regulatory networks in animal development (EVONET)
Date du début: 1 oct. 2008, Date de fin: 30 sept. 2012,
"Genetic and mutant analyses in Drosophila and other standard model organisms have revealed hierarchical gene networks and identified some key regulatory genes acting in animal development. While surprising conservation exists on a broad scale between distant phyla, significant differences have also been detected. Systems biology approaches in the main model systems have now revealed more complex ...
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7
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TERMINÉ
European Network on the Health and Environmental Impact of Nanomaterials (NanoImpactNet)
Date du début: 1 avr. 2008, Date de fin: 31 mars 2012,
Recent technological advances allow the targeted production of objects and materials in the nanoscale (smaller than 100 nm). Nanomaterials have chemical, physical and bioactive characteristics, which are different from those of larger entities of the same materials. Nanoparticles can pass through body barriers. This is interesting for medical applications, but it raises concerns about their health ...
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26
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TERMINÉ
Proneural mechanisms coupling cell cycle exit and differentiation (PROCYCDIF)
Date du début: 1 juin 2009, Date de fin: 31 mai 2011,
"Understanding how a neuron develops is one the most challenging enterprises of modern biology, with obvious impacts in developmental biology and biomedicine. Proneural factors regulate many of the steps involved in the generation of new neurons and their functions have been thoroughly characterised at the cellular level. However, little is known of the mechanisms they use to evoke such diverse ef ...
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1
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TERMINÉ
Temporal regulation by Sonic Hedgehog of neural progenitor identity during vertebrate neurogenesis (TempIntShh)
Date du début: 12 août 2008, Date de fin: 11 août 2010,
The central nervous system (CNS) is the most complex organ in the vertebrate body, and the patterning of the developing CNS is comprised of a large number of regulatory steps. Many extracellular molecules play critical roles in the precise patterning of the CNS during embryonic development. Among them, Sonic Hedgehog (Shh), a soluble factor produced by the floor plate and notochord, is a strong ca ...
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1
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TERMINÉ
Anterograde regulation of axon targeting in the Drosophila visual system (Axon targeting)
Date du début: 15 juin 2008, Date de fin: 14 juin 2010,
To understand how a functional nervous system generates complex behaviors, it is essential to determine the molecular mechanisms that direct the formation of precise connections between afferent axons and their targets during development. In the Drosophila visual system, neuronal circuit assembly depends on intricate bidirectional interactions between photoreceptor axons and target neurons. Anapla ...
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