5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Persisting Transgenesis (PERSIST)
Date du début: 1 janv. 2009, Date de fin: 30 juin 2013,
"For many disabling or fatal diseases, there is pre-clinical or clinical evidence of the potential therapeutic efficacy of gene therapy and, yet, the limitations of current gene transfer technologies have prevented success or even caused serious adverse events leading to termination of trials. PERSIST will explore the use of highly innovative gene-modifying and delivery technologies and capitalize ...
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29
Participants partenaires
TERMINÉ
Defining regulators of hematopoietic stem cell homing and engraftment (HemHome)
Date du début: 1 juil. 2010, Date de fin: 24 févr. 2013,
Transplantation of hematopoietic stem cells (HSC) is a life-saving treatment for many serious diseases. Unfortunately, the procedure is often hampered by insufficient numbers of donor stem cells and attempts to expand HSCs ex vivo prior to transplantation have remained unsuccessful. An important alternative, which significantly would reduce the required number of donor cells, is to enhance the eng ...
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1
Participant partenaire
TERMINÉ
Identification of novel factors to expand hematopoietic stem cells in vitro (NOVEXPAND)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2012,
"Blood and marrow transplantation (BMT) has been used successfully to treat malignant blood disorders and genetic diseases. Although BMT has been effective, problems remain, for example lack of suitable donors and engraftment failure. Cord blood (CB) contains hematopoietic stem cells (HSC) that can be used to transplant children. However, there are too few HSC in most CB samples to reliably engraf ...
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1
Participant partenaire
TERMINÉ
Stem Cell Expansion - Expansion and engraftment of haematopoietic and mesenchymal stem cells (STEMEXPAND)
Date du début: 1 nov. 2008, Date de fin: 31 oct. 2011,
"Serious disorders of the blood system, particularly malignant blood disorders and genetic diseases can be effectively treated by blood and marrow transplantation. Despite considerable success with this treatment modality during the last decades, lack of suitable donors, engraftment failure and graft versus host disease remain serious problems that need to be addressed. This project aims to addres ...
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8
Participants partenaires
TERMINÉ
A European Consortium for Lysosomal Disorders (EUCLYD)
Date du début: 1 mai 2008, Date de fin: 30 avr. 2011,
"The EUCLYD consortium aims at developing a scientific network among outstanding communities of basic and clinical investigators in five European countries (Italy, Netherlands, UK, Sweden and Germany) to study various aspects of lysosomal storage diseases (LSD). LSDs are rare disorders (overall prevalence of 1/5000 to 1/8000), each due to a specific lysosomal enzyme deficiency, leading to intracel ...
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