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The science of complex systems distinguishes linear from non-linear dynamics. Simpler systems can often be satisfactory described by linear models, but complex systems require non-linear models that can capture more of the characteristics of such systems, such as thresholds, feedback loops, avalanche effects, and irreversibility. Linear systems can be validated by aligning models to the past and u ...

Adverse Drug Events (ADE) due to product safety problems, and medication errors due to human factors (HF) are a major Public Health issue. They endanger the patients' safety and originate considerable extra hospital costs.Healthcare ICT applications should help reducing the prevalence of preventable ADE, by providing healthcare professionals and patients with relevant knowledge (guidelines, recomm ...