4 projets européens trouvés
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TERMINÉ
Reach α-synuclein-dependent neurodegeneration: clinical development of therapeutic AFFITOPE vaccines for Parkinson’s disease and multisystem atrophy (SYMPATH)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
The goal of SYMPATH is to advance clinical development of therapeutic vaccines targeting α-synuclein (aSyn)-driven neurodegenerative diseases (ND). It addresses Parkinson’s disease (PD) and multiple system atrophy (MSA), two synucleopathies, for which no causal therapy exists. Ultimately, both lead to patient disability and death, which along with patient number (PD) and age of onset (MSA, PD) def ...
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8
Participants partenaires
TERMINÉ
A RANDOMIZED CLINICAL TRIAL TO EVALUATE THE EFFECTIVENESS OF A MULTI-MODAL INTERVENTION IN OLDER PEOPLE WITH TYPE 2 DIABETES ON FRAILTY AND QUALITY OF LIFE: THE MID-FRAIL STUDY (MID-FRAIL-STUDY)
Date du début: 1 mars 2012, Date de fin: 30 avr. 2017,
The prevalence of diabetes in people ≥ 65 years approaches 25% (40% of all patients with diabetes are > 65 years). This number will increase 4-fold in people > 70 years in 2050. Diabetes results in a high personal and social health burden, and a significant public health burden in terms of rising healthcare costs. Diabetes is associated with increased functional decline in older people and may exp ...
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17
Participants partenaires
TERMINÉ
The European Network for Translational Research in Atrial Fibrillation (EUTRAF)
Date du début: 1 nov. 2010, Date de fin: 31 oct. 2015,
"The initiation and perpetuation of atrial fibrillation (AF) can be regarded as a complication of a progressive transformation of the structure and functional properties of the atria. This transformation is the result of complex and multiple changes at the molecular, cellular and organ levels which interact to form the basis for proarrhythmic mechanisms in AF. Numerous individual and environmental ...
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20
Participants partenaires
TERMINÉ
Application of MRI to explore myocardial structural reorganisation accompanying contraction and the influence of this on arrhythmogenesis the normal and post infarct heart (MSIA)
Date du début: 1 mai 2012, Date de fin: 30 avr. 2014,
"Understanding of normal and abnormal cardiac excitation and contraction requires the integration of knowledge of myocyte electrophysiology and mechanics with knowledge of dynamic myocardial architecture.The myocardium is structured as stacked 4-6 cells thick (~100 µm) laminae of myocytes, which have a complex architectural arrangement throughout the cardiac wall and have localised regions of abru ...
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