3 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Gene Therapy for X-linked Chronic Granulomatous Disease (CGD) (NET4CGD)
Date du début: 1 déc. 2012, Date de fin: 31 mai 2018,
This project is focused on the clinical development of a new orphan drug that can rapidly become a new treatment option for patients with the X-linked form of chronic granulomatous disease (X-CGD). This rare primary immune deficiency of phagocytes is caused by mutations in the gp91phox gene. Affected patients are highly-susceptible to infections and develop inflammatory granulomas. Several member ...
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11
Participants partenaires
TERMINÉ
Phase I/II ex vivo gene therapy clinical trial for recessive dystrophic epidermolysis bullosa using skin equivalent grafts genetically corrected with a COL7A1-encoding SIN retroviral vector (GENEGRAFT)
Date du début: 1 mars 2011, Date de fin: 31 déc. 2017,
RDEB is one of the most severe rare genetic skin diseases of children and adults characterized by skin blistering resulting from lack of expression of type VII collagen. There is no treatment for this life-threatening disease. In March 2009, we obtained the orphan drug designation for the Medicinal product: “Skin equivalent graft genetically corrected with a COL7A1-encoding SIN retroviral vecto ...
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10
Participants partenaires
TERMINÉ
Integrated Human Modelling and Simulation to support Human Error Risk Analysis of Partially Autonomous Driver Assistance Systems (ISi-PADAS)
Date du début: 1 sept. 2008, Date de fin: 31 août 2011,
The main objective of the ISi-PADAS project is to provide an innovative methodology to support risk based design and approval of Partially Autonomous Driver Assistance Systems (PADAS) focusing on elimination and mitigation of driver errors by an integrated Driver-Vehicle-Environment modelling approach. The methodology contributes to (1) halving the number of road fatalities by 2010 (respect to 200 ...
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