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Plus de 40 projets européens trouvés

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 TERMINÉ 

Combatting Bacterial Resistance in Europe (COMBACTE-NET)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2019,

The emergence of Antibiotic-resistant bacteria (ARB) is a global problem, having recently been elevated to the top three threats identified by the World Health Organisation (WHO), and subject of numerous national and international government activities, including the Trans-Atlantic Task Force on Antimicrobial Resistance established by the US and EU presidencies. The estimated costs of ARB are aro ...
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 38

 TERMINÉ 

Reconstructing Earth’s mantle convection (AUGURY)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

"Knowledge of the state of the Earth mantle and its temporal evolution is fundamental to a variety of disciplines in Earth Sciences, from the internal dynamics to its many expressions in the geological record (postglacial rebound, sea level change, ore deposit, tectonics or geomagnetic reversals). Mantle convection theory is the centerpiece to unravel the present and past state of the mantle. For ...
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 3

 TERMINÉ 

Genetics and cell biology of K2P channels (Kelegans)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Two-pore domain potassium channels (K2P) maintain the resting membrane potential of animal cells and therefore play a central role in the control of cellular excitability. In the vertebrate nervous system, various neuromodulators promote K2P closure, which depolarizes neurons, increases neuronal excitability and ultimately affects action potential firing. Knockout studies have revealed important r ...
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 2

 TERMINÉ 

Clusters And LENsing of Distant Sources (CALENDS)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

"Some of the primary questions in extragalactic astronomy concern the formation and evolution of galaxies in the distant Universe. In particular, little is known about the less luminous (and therefore less massive) galaxy populations, which are currently missed from large observing surveys and could contribute significantly to the overall star formation happening at early times. One way to overcom ...
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 2

 TERMINÉ 

Bioactive materials for enhanced preventative and restorative dental solutions (BIODENSOL)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2018,

"This project proposes three PhD studies to address the problems of (i) Caries and (ii) enamel erosion by acidic foods (leading to sensitive teeth). In both cases, encouraging re-mineralisation (the formation of new calcium phosphate) can help avoid these problems. Where restorative work is required, re-mineralisation has potential to enhance the lifetime of restorations and so further reduce the ...
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 3

 TERMINÉ 

Metal Hybrid Cavities (HyMeCav)

Date du début: 1 juin 2014, Date de fin: 31 janv. 2018,

Quantum semiconductor microcavities are structures in which photons can be confined within an area whose size is comparable to the wavelength of light. In this scenario, light-matter interactions can be substantially enhanced. A traditional microcavity is composed of two dielectric or semiconductor Bragg reflectors confining an active area which contains a quantum object such as a quantum well. F ...
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 7

 TERMINÉ 

Improving Outcome of Necrotizing Fasciitis: Elucidation of Complex Host and Pathogen Signatures that Dictate Severity of Tissue Infection (INFECT)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The overall goal with INFECT is to advance our understanding of the pathophysiological mechanisms, prognosis, and diagnosis of the multifactorial highly lethal NSTIs. The fulminant course of NSTIs (in the order of hours) demands immediate diagnosis and adequate interventions in order to salvage lives and limbs. However, diagnosis and management are difficult due to heterogeneity in clinical presen ...
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 16

 TERMINÉ 

Evolution of Mars (E-MARS)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2017,

The primary questions that drive the Mars exploration program focus on life. Has the Martian climate ever been favorable for life development? Such scenario would imply a distinct planetary system from today with a magnetic flied able to retain the atmosphere. Where is the evidence of such past climate and intern conditions? The clues for answering these questions are locked up in the geologic rec ...
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 1

 TERMINÉ 

NanoBioEngineering of BioInspired BioPolymers (Nano3Bio)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

The Nano3Bio project convenes a consortium of world renowned experts from 8 EU universities, 1 large company, and 14 SME, to develop biotechnological production systems for nanoformulated chitosans. Chitosans, chitin-derived polysaccharides varying in their degree of polymerisation (DP), degree of acetylation (DA), and pattern of acetylation (PA), are among the most versatile and most promising bi ...
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 23

 TERMINÉ 

Real time monitoring of SEA contaminants by an autonomous Lab-on-a-chip biosensor (SEA-on-a-CHIP)

Date du début: 1 déc. 2013, Date de fin: 31 mai 2017,

Early warning systems that can provide extreme sensitivity with exquisite selectivity are required to assess chemical contamination of estuarine and coastal areas. SEA-on-a-CHIP aims to develop a miniaturized, autonomous, remote and flexible immuno-sensor platform based on a fully integrated array of micro/nano-electrodes and a microfluidic system in a lab-on-a-chip configuration combined with ele ...
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 19

 TERMINÉ 

Position and Personalize Advanced Human Body Models for Injury Prediction (PIPER)

Date du début: 1 nov. 2013, Date de fin: 30 avr. 2017,

"In passive safety, human variability is currently difficult to account for using crash test dummies and regulatory procedures. However, vulnerable populations such as children and elderly need to be considered in the design of safety systems in order to further reduce the fatalities by protecting all users and not only so called averages.Based on the finite element method, advanced Human Body Mod ...
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 14

 TERMINÉ 

The Dependence Receptors notion: from a cell biology paradigm to anti-cancer targeted therapy (DEPREC)

Date du début: 1 mai 2012, Date de fin: 30 avr. 2017,

"While it is assumed that transmembrane receptors are active only in the presence of ligand, we have proposed that some receptors may also be active in the absence of ligand stimulation. These receptors, named “dependence receptors” (DRs) share the ability to transmit two opposite signals: in the presence of ligand, these receptors transduce various classical “positive” signals, whereas in the abs ...
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 1

 TERMINÉ 

Transforming Magnetic Resonance Spectroscopy into a Clinical Tool (TRANSACT)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

"In vivo Magnetic Resonance Spectroscopy and Spectroscopic Imaging (MRS(I)) are unique, indispensable techniques for non-invasive metabolic imaging. Important areas where MRS(I) can make a difference are oncology and neurology, where metabolic changes due to, e.g., tumour formation, can be detected earlier and more sensitively than with morphological imaging modalities alone. Despite its huge prov ...
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 10

 TERMINÉ 

One component waterborne barrier coatings (BARRIER PLUS)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2016,

"Steel is the most used metal in construction and the costs of protecting Europe’s structural steel installations and assets from corrosion is thought to be 3% of GDP (or about €375BN). However, there are two factors that will increasingly affect future protective coatings developments: VOC emissions and health/safety issues. Firstly there is a strong mandate to apply VOC emissions legislation to ...
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 11

 TERMINÉ 

Nanofluidics inside a single carbon nanotube (MICROMEGAS)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2016,

"Nanofluidics is an emerging field aiming at the exploration of fluid transport at the smallest scales. Taking benefit of the specific properties of fluids in nanoconfinement should allow to challenge the limits of macroscopic continuum frameworks, with the ultimate aim of reaching the efficiency of biological fluidic systems, such as aquaporins. Carbon nanotubes have a decisive role to play in th ...
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 1

 TERMINÉ 

Micro/nanosensors for early cancer warning system - diagnostic and prognostic information (SMARTCANCERSENS)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

"Oncologists still rely heavily on biological characterisation of tumours and a limited number of biomarkers which have demonstrated clinical utility. Routine cancer diagnostic tools may not be always sensitive enough and may only detect proteins at levels corresponding to an advanced stage of the disease. Recently, new genomic and proteomic molecular tools (molecular signatures) are being employe ...
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 6

 TERMINÉ 

Chimeric Influenza-VLP used as vaccine platform for presentation of foreign antigens - Application to Malaria antigens (FLU-MAL VLP)

Date du début: 1 sept. 2014, Date de fin: 21 déc. 2016,

"The goal of this project is to provide a new antigen delivery system for vaccination purpose. We want to develop a vaccine platform based on pseudo-viral particles (VLP), able to enhance antigen immunogenicity and allow for screening multiple antigens independently or simultaneously. A chimeric influenza-VLP platform will be construct, where hemagglutinin (HA) protein will be modified to accommod ...
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 2

 TERMINÉ 

European Clinical trials in Rare Sarcomas within an integrated translational trial network (EUROSARC)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,

Sarcomas are rare malignant tumors, with an overall incidence of 6/105/year. Bone and soft tissue connective tissue tumours encompass more than 50 different rare histotypes and more than 150 different molecular subtypes. The incidence of individual rare sarcomas subtypes is often less than 0.5/105/year. Given sarcoma rarity as a group, but even more as individual entities, few prospective clinical ...
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 22

 TERMINÉ 

Chiral Base C−H Activation (CHIBACHA)

Date du début: 3 nov. 2014, Date de fin: 2 nov. 2016,

"The goal of this proposal is to develop a new strategy for asymmetric C(sp3)−H activation using a chiral base instead of chiral ligand, and will focus on oxidative addition-induced and decarboxylation-induced reactions. Using this new strategy, a wide range of representative and valuable chiral four-membered (hetero)cyclic and five-membered (hetero)cyclic organic molecules will be synthesized.Typ ...
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 3

 TERMINÉ 

Innovative Radiochemistry to Advance Molecular Imaging (RADIOMI)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

The RADIOMI Initial Training Network (ITN) has the goal of providing training in a superbly suited academic and industrial environment uniquely equipped to conduct a scientific research program that addresses one of the key aspects of functional imaging, the underpinning radiochemistry essential for preparation of radiotracers currently difficult or not possible to access. This will be exploited f ...
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 9

 TERMINÉ 

Evolution of Evolution (EvoEvo)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2016,

Evolution is the major source of complexity on Earth, at the origin of all the species we can observe, interact with or breed. On a smaller scale, evolution is at the heart of the adaptation process for many species, in particular micro-organisms (e.g. bacteria, viruses...). Microbial evolution results in the emergence of the species itself, and it also contributes to the organisms' adaptation to ...
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 7

 TERMINÉ 

The Human Brain Project (HBP)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,

Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to the challenge, we can gain profound insights into what makes us human, develop new treatments for brain diseases and build revolutionary new computing technologies. Today, for the first time, modern ICT has brought these goals within sight. The goal of the Human Brain Project, part of the ...
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 116

 TERMINÉ 

A Computational Environment to Stimulate and Enhance Creative Designs for Mathematical Creativity (M C Squared)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,

The M C Squared project will design and develop an intelligent digital environment to support stakeholders from creative industries involved in the production of media content for educational purposes to engage in collective forms of creative thinking and working to co-design appropriate digital media. The focus will be on social creativity in the design of digital media intended to enhance creati ...
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 12

 TERMINÉ 

Genetic and environmental factors of insulin resistance syndrome and its long-term complications in immigrant Mediterranean populations (MEDIGENE)

Date du début: 1 janv. 2012, Date de fin: 31 juil. 2016,

MEDIGENE project will study genetic and environmental (G x E) determinants of the metabolic syndrome (MetS) in recent immigrants in Europe by a novel approach integrating ancestry of Mediterranean populations in epidemiology, locus refining and Genome Wide Association Studies (GWAS). West Mediterranean shores are place of pre-historical termini of population expansion from Southern Europe and Nort ...
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 22

 TERMINÉ 

ASSESSMENT OF THE SAFETY OF LABAS IN ASTHMA IN ROUTINE CARE BY COMBINING HEALTH-CARE DATABASES AND DIRECT PATIENT FOLLOW-UP (ASTRO-LAB)

Date du début: 1 déc. 2011, Date de fin: 31 mai 2016,

Background: The efficacy of long-acting β-agonists (LABAs) in asthma has been demonstrated but their safety remains an issue, particularly in children. Co-therapy with inhaled corticosteroids (ICs) is recommended in persistent asthma. However, drug-use studies suggest frequently inadequate IC adherence, possibly explaining the occurrence of exacerbations. There is a need for detailed analyses of p ...
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 9

 TERMINÉ 

POWER SoC With Integrated PassivEs (PowerSwipe)

Date du début: 1 oct. 2012, Date de fin: 31 mars 2016,

Europe is a world leader in innovative automotive systems with competencies covering the full supply chain from the main OEMs (Audi, BMW, Daimler, Fiat, PSA, RSA, VW) to Tier1 suppliers (Bosch, Continental, Magneti Marelli) to leading semiconductor companies (Infineon, ST). The vision for electronic automotive control units in 2020 is that the battery will supply multi-core µControllers via multip ...
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 9

 TERMINÉ 

Fundamentals and Applications of Nano-Carbon Electron Emitters (FANCEE)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,

Development of efficient electron sources is crucial for a wide range of applications including integrated vacuum microelectronics, MEMS, bright flat panel displays, energy conversion devices, and compact microwave amplifiers. In the search for new cathodes capable to produce a strong electron flux at low energy consumption, carbon materials possessing extraordinary field emission properties have ...
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 3

 TERMINÉ 

EUropean TRanslational training for Autoimmunity & Immune manipulation Network (EUTRAIN)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

Immune-mediated inflammatory diseases (IMID) are important health challenges in Europe and beyond, afflicting an estimated 5-8% of the total population. IMID with an onset during childhood such as Juvenile Idiopathic Arthritis (JIA) cause particular concern as pediatric patients form an especially vulnerable group. Currently there is no safe and cost-effective cure for JIA and related juvenile IMI ...
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 11

 TERMINÉ 

INTEGRATED NANODEVICES (NANODEV)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2015,

The primary objective of this proposal is to carry the results, knowledge, and international collaboration gained throughout our first project (NANOBIOSOENS) that was conducted as a part of IRSES call in the last 3 years to the next level, which will focus on nanodevices and advanced applications. The proposed research project is focused on two different applications, main one being on biosensors ...
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 2

 TERMINÉ 

3D spectroscopy of lensing cluster fields (3DLENS)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

We propose to use new European astronomical facilities in conjunction with the power of massive galaxy clusters used as gravitational telescopes in order to explore the question of galaxy formation and evolution. In particular, new spectroimagers such as the Multi-Unit Spectroscopic Explorer (MUSE) on the Very Large Telescope and the Atacama Large Millimetre Array (ALMA) allow to directly access ...
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 1

 TERMINÉ 

Evaluation of antibiotics (ciprofloxacin and fluconazole) for the treatment of infections in preterm and term neonates (TINN)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2015,

The aim of TINN is to evaluate ciprofloxacin, fluconazole and micafungin in neonates; two anti-infectious drugs included in the EMEA priority list of the therapeutic areas that need specific drug evaluation in preterm and term neonates. These drugs are prescribed off-label to treat neonatal infections that are life threatening situations and associated with long-term complications. In order to val ...
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 16

 TERMINÉ 

Water anomalies in the stretched and supercooled regions (WASSR)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2015,

Water is the most abundant liquid on Earth s surface. It is essential for life. Surprisingly, despite extensive studies, many of its properties remain to be explained. The aim of this project is to contribute to the understanding of water, by studying its anomalies in the metastable liquid state. A liquid should transform into vapour at its boiling point, or into a solid at its freezing point. How ...
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 2

 TERMINÉ 

Study on the need for food and health research infrastructures in Europe (EURO DISH)

Date du début: 1 sept. 2012, Date de fin: 31 août 2015,

"Europe is facing major challenges in promoting health and reducing the disease burden of age- and diet-related NCDs by means of lifestyle, food and nutrition. Research collaboration, innovation, and capacity building are essential to efficiently benefit from the – mainly public – research resources. To realise this, EU-wide Research Infrastructures (RIs) are essential. The aim of EURO-DISH is to ...
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 18

 TERMINÉ 

Bacterial Formation of Glycerol (di)Ether Lipids: Biogeochemical, (paleo)environmental and evolutionary implications (BAGEL)

Date du début: 1 sept. 2013, Date de fin: 31 août 2015,

The three domains of life on Earth comprise the two groups of prokaryotes Archaea and Bacteria whom distinction notably relies on the chemical composition of cellular membranes. Bacteria generally synthesize phospholipids constituted of non-isoprenoid alkyl chains esterified to glycerol, whereas Archaea synthesize isoprenoid ethers of glycerol. These differences have potential implications in term ...
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 2

 TERMINÉ 

Vaccines against helminth infections (PARAVAC)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,

Livestock production efficiency is impaired by helminth infection which is ubiquitous in cattle, sheep and goats world-wide. It causes severely debilitating gastro-intestinal, respiratory and hepatic disorders, dependent on the infecting species. The treatment and prevention of helminth parasitism in livestock continues to rely almost exclusively on the use of anthelmintic drugs, an approach thre ...
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 26

 TERMINÉ 

Mucin binding to bioactive molecules: physiological role and new biomaterials (BIOMUC)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2015,

Mucins are high molecular weight glycoproteins, responsible for most of the extraordinary properties of the mucosal layer, which covers around 300 m2 of our body’s surface. Mucins have mostly been studied in the context of their physiological role: for their ability to protect the epithelial layer from viral and bacterial infection, oxidative degradation, dehydration and mechanical stresses. They ...
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 1

 TERMINÉ 

Training NETwork on Functional Interfaces for SiC (NETFISIC)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,

"The main scientific objective of NetFISiC is to provide Silicon carbide material (of various polytypes) with improved and adequate functional interfaces for getting a step forward in electronic devices performance. Research efforts will be dedicated to solve the problems faces by important devices like MOSFET and Schottky diodes. Besides, some fundamental research will be performed both on the gr ...
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 12

 TERMINÉ 

Research Training in 3D Digital Imaging for Cancer Radiation Therapy (ENTERVISION)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,

The vision on a future high-precision radiation therapy utilizing either particle or photon beams is a treatment on a technological level which allows for: (1) obtaining information on relevant tumour parameters (volume, position, topology, density - also of the surrounding tissue) during every moment of therapeutic irradiation; (2) adapting the treatment plan in real time; and (3) initiating the ...
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 12

 TERMINÉ 

European Training Network on Cancer-Induced Bone Diseases (BONE-NET)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,

Several cancers are prone to metastasize to bone. Combating bone metastasis, especially the early dissemination of cancer cells in bone, requires basic research knowledge, skills in different technologies and longstanding clinical experience in order to make clinically significant progress. BONE-NET is a european consortium with complementary expertises in the fields of cancer and bone. It brings ...
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 11

 TERMINÉ 

BOmb factory detection by Networks of Advanced Sensors (BONAS)

Date du début: 1 avr. 2011, Date de fin: 31 déc. 2014,

"The aim of BONAS is to design, develop and test a novel wireless sensors network for increasing citizen protection and homeland security against terrorist attacks, in particular against the threat posed by IED devices. The sensor network will focus on the detection of traces of precursors used in IED production (particulates, gases and/or waterborne) present in the environment surrounding the vic ...
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 14