5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Gene Therapy for X-linked Chronic Granulomatous Disease (CGD) (NET4CGD)
Date du début: 1 déc. 2012, Date de fin: 31 mai 2018,
This project is focused on the clinical development of a new orphan drug that can rapidly become a new treatment option for patients with the X-linked form of chronic granulomatous disease (X-CGD). This rare primary immune deficiency of phagocytes is caused by mutations in the gp91phox gene. Affected patients are highly-susceptible to infections and develop inflammatory granulomas. Several member ...
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11
Participants partenaires
TERMINÉ
Phase I/II Gene Therapy Trial of Fanconi anemia patients with a new Orphan Drug consisting of a lentiviral vector carrying the FANCA gene: A Coordinated International Action (EUROFANCOLEN)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
Fanconi anemia (FA) is a rare inherited syndrome characterized by the early development of bone marrow failure and increasing predisposition to cancer with age. Allogeneic hematopoietic cell transplantation (alloHCT) is the only curative therapy for hematopoietic manifestations of FA, although associated with complications arising from myeloablation, graft versus host disease and increased inciden ...
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13
Participants partenaires
TERMINÉ
EPIGENETICS FOR FEMALE PERSONALIZED CANCER CARE (EPI-FEM-CARE)
Date du début: 1 nov. 2012, Date de fin: 30 avr. 2016,
CLINICAL NEEDEvery year in the EU ~45,300 and 330,000 women are diagnosed with ovarian and breast cancer respectively & 28,800 and 90,000 of these two groups of women will die as a consequence of these diseases. Currently there are no tools available that allow for:a) Effective screening of ovarian and/or breast cancer of sufficient sensitivity and specificity to avoid potential over-diagnosis, or ...
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6
Participants partenaires
TERMINÉ
BEAN – Bridging the European and Anatolian Neolithic: Demography, Migration, and Lifestyle at the Advent of Civilization (BEAN)
Date du début: 1 févr. 2012, Date de fin: 31 janv. 2016,
One of the most interesting questions in prehistory is that of the origins of European peoples following the introduction of settled farming life to the continent some 8,000 years ago. The interdisciplinary BEAN network will address this by combining teaching and research in three different fields: i) Anthropology and genetics, ii) computer simulation and modelling, and iii) prehistoric archaeolog ...
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8
Participants partenaires
TERMINÉ
Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2014,
Lung transplantation (LT) is the standard of care for selected patients with chronic respiratory failure. Chronic lung allograft dysfunction (CLAD) (i.e. “Bronchiolitis obliterans syndrome” (BOS) and “Restrictive Allograft Syndrome” (RAS)) represents a major health risk for LT recipients, requiring the use of heavy treatments and possible retransplantation. Observed in almost 50% of patients afte ...
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