3 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Predicting long-term toxic effects using computer models based on systems characterization of organotypic cultures (NOTOX)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,
"NOTOX will develop and establish a spectrum of systems biological tools including experimental and computational methods for i) organotypic human cell cultures suitable for long term toxicity testing and ii) the identification and analysis of pathways of toxicological relevance. NOTOX will initially use available human HepaRG and primary liver cells as well as mouse small intestine cultures in 3D ...
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13
Participants partenaires
TERMINÉ
Detection of endpoints and biomarkers of repeated dose toxicity using in vitro systems (DETECTIVE)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,
"Assessment of repeated dose toxicity is a standard requirement in human safety evaluation and relies on animal testing as no alternatives are currently accepted for regulatory purposes. An integrated research strategy for the replacement of animal tests needs to comprise the development of biomarkers of long-term toxicity in human target cells. To this aim, the DETECTIVE project will set up a scr ...
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15
Participants partenaires
TERMINÉ
The Body-on-a-Chip (BoC) (BOC)
Date du début: 1 juin 2012, Date de fin: 31 mai 2015,
High attrition and failures rates in pharmaceutical and biotechnological drug development require a paradigm change towards more physiological human cell-based assays at an early time point in the process. The central idea of this proposal is to develop a versatile and reconfigurable pharmaceutical screening technology platform that relies on organotypic three-dimensional spherical microtissues. T ...
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