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 TERMINÉ 

Vascular remodelling and miRNA therapeutics (VASCMIR)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,

The central hypothesis of VascmiR is that microRNAs (miRs) fundamentally control pathological remodelling of the vasculature. The complexity of vascular bed heterogeneity and subsequent response to injury, the potential importance of miRNA in vascular pathology and the paucity in knowledge relating to many facets of miRNA function in the vessel wall including target pathways, mechanistic features ...
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 2

 TERMINÉ 

Twists & more: the complex shape of light (TWISTS)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

"My scientific career to date has centered around the phase and intensity shaping of light beams, specifically for the pioneering studies of Orbital angular momentum.I wish to build upon this foundation applying twisted and shaped light to sensing and imaging in both the classical and quantum domains.I will use orbital angular momentum as a new imaging modality and as the basis as a remote sensor ...
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 1

 TERMINÉ 

Advanced Microfluidics & Diagnostics using Acoustic Holograms – Bio-Phononics (Bio-Phononics)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

This proposal seeks to develop a novel technique for fluid and particle manipulations, based upon exploiting the mechanical interactions between acoustic waves and phononic. The new platform involves generating surface acoustic waves (SAWs) on piezoelectric chips, but, unlike previous work, the ultrasonic waves are first coupled into a phononic lattice, which is placed in the path of the ultrasoni ...
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 1

 TERMINÉ 

Heart OMics in AGEing (HOMAGE)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2019,

As more people survive into old age, the prevalence of heart failure (HF), one of the most common and debilitating diseases in older people, will rise still further. Delaying or preventing HF will have great benefit to those at personal risk, their families, society and the economy. HOMAGE aims to provide a biomarker (BM) approach that will a) help identify i. patients at high risk of developing ...
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 22

 TERMINÉ 

Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease: Comparative Effectiveness Research of Existing Technologies (DISCHARGE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Coronary artery disease (CAD) is the leading cause of death in high-income countries. Invasive coronary angiography (ICA) is the reference standard for the diagnosis of CAD and allows immediate therapy. However, only 40% of patients undergoing ICA actually have obstructive CAD and ICA has relatively rare but considerable risks. Coronary computed tomography (CT) is the most accurate diagnostic test ...
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 38

 TERMINÉ 

Social innovation to improve physical activity and sedentary behaviour through elite European football clubs: European Fans in Training (EuroFIT)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Concept and aim: 20 million fans attend top division football games each week and many more watch on TV. Our social innovation is to attract people to lifestyle change through the personal connection and loyalty to the club they support. Our aim is to use this social innovation to change physical activity and sedentary behaviour, specially targeting low-SES groups, and men as well as women. EuroFI ...
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 13

 TERMINÉ 

Harnessing Cavitation for Therapy (TheraCav)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Focused Ultrasound Surgery (FUS) is rapidly emerging as a technique setting the gold-standard for the treatment of a wide range of diseases, including cancer. Current practise relies on the conversion of acoustic energy to thermal, for localised and minimally-invasive ablation with non-ionising radiation. Cavitation (the formation, and subsequent pressure driven dynamics, of bubbles) is a common o ...
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 2

 TERMINÉ 

Inflammation and Immunity in Human Hypertension and Vascular Dysfunction (ImmunoTension)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,

Hypertension is a major cause of death and disability in Europe and in the rest of the World. It affects 30% of adults, and additional 30% are at very high risk of developing hypertension. This is an enormous health problem as it is a cause of subsequent renal failure, stroke, myocardial infarction and heart failure. Despite extensive research, the mechanisms of most cases of hypertension remain u ...
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 1

 TERMINÉ 

Material-driven Fibronectin Fibrillogenesis to Engineer Synergistic Growth Factor Microenvironments (HEALINSYNERGY)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

"Cells within tissues are surrounded by fibrillar extracellular matrices (ECM) that support cell adhesion, migration, proliferation and differentiation. Fibronectin (FN) is an ECM protein organized into fibrillar networks by cells through an integrin-mediated process. This assembly allows the unfolding of the molecule, exposing cryptic domains not available in the native globular FN structure and ...
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 2

 TERMINÉ 

New connections in low-dimensional topology: Relating Heegaard Floer homology and the fundamental group (HFFUNDGRP)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2018,

"Low-dimensional topology is a central and exciting area of 21st century research mathematics that has enjoyed a period of intense activity in recent years. On the one hand, steady progress in understanding the deep connections between group theory and three-manifold topology has led to the resolution of long-standing conjectures; on the other, the introduction of modern homological invariants (e. ...
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 1

 TERMINÉ 

Parasite-specific cyclic nucleotide phosphodiesterase inhibitors to target Neglected Parasitic Diseases (PDE4NPD)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,

This project aims to unite global efforts to target the highly druggable class of enzymes called cyclic nucleotide phosphodiesterases (PDEs) in the fight for neglected parasitic diseases (NPD). It will establish a drug discovery platform, PDE4NPD, that combines phenotypic screening with efficient target-centric drug discovery, including target validation, various strategies for compound screening, ...
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 11

 TERMINÉ 

The role of ryanodine cluster morphology in arrhythmogenic calcium release after myocardial infarction (Cardiocluster)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,

Contraction of the heart occurs by the intracellular release of calcium through channels called ryanodine receptors (RyR), after electrical activation. Due to the progression of heart disease, structural and functional remodeling of at the level of the cardiac cell is known to occur. This remodeling process alters the electrical properties of the heart muscle cell and can lead to the production o ...
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 1

 TERMINÉ 

Technological Evolution of Synergy Between Physicochemical and Living Systems (EVOBLISS)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

We will develop artificial, technological evolution and use it to design functional ecosystems consisting of up to three forms of living technology, namely, artificial chemical life, living microorganisms, and complex chemical reaction networks for the purpose of improved treatment and cleanup of wastewater for energy generation. The goals of this project are i) develop a general, robotic platform ...
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 6

 TERMINÉ 

Endosomal dependent transport to the unique secretory organelles of apicomplexan parasites (EndoTox)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,

Apicomplexan parasites invade the host cell in an active process that involves gliding motility, formation and movement through the moving junction (MJ) and establishment of a prasitophorous vacuole (PV) around the parasite. In order to invade the host cell they employ an arsenal of virulence factors derived from the specialised secretory organelles; the micronemes, rhoptries and dense granules th ...
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 1

 TERMINÉ 

New directions for studying circadian biology in the wild (WildClocks)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

Powered by molecular tools, circadian research rapidly reveals a key role of biological rhythms in physiology and health, but clock function is poorly understood in its organismic and environmental context. Because clocks integrate multiple rhythmic processes, they need to be finely adjusted to environmental conditions. To address how genes and environment shape timekeeping, I combine frontline mo ...
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 1

 TERMINÉ 

European Medical Information Framework (EMIF)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

In response to the need to tackle increasingly complex medical research questions, a growing amount of human health data is being collected, either in routine Electronic Healthcare Record (EHR) databases, through research-driven cohort studies, in biobanks or related efforts. However, data sources are typically fragmented and contain information gaps which prevent their full exploitation. EMIF aim ...
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 64

 TERMINÉ 

Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy In TYpe 2 diabetic patients with normoalbuminuria (PRIORITY)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,

Patients with diabetes are at risk of developing diabetic nephropathy, which will ultimately result in the requirement for renal replacement therapy and is also associated with high cardiovascular morbidity and mortality. Detection of low concentrations of albuminuria in urine (microalbuminuria) is the current clinical standard for detecting those at significant risk and targeting preventive treat ...
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 21

 TERMINÉ 

Brain reading of contextual feedback and predictions (BrainReadFBPredCode)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,

We are currently witnessing a paradigm shift in our understanding of human brain function, moving towards a clearer description of cortical processing. Sensory systems are no longer considered as 'passively recording' but rather as dynamically anticipating and adapting to the rapidly changing environment. These new ideas are encompassed in the predictive coding framework, and indeed in a unifying ...
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 1

 TERMINÉ 

QUANTItative scanning probe microscopy techniques for HEAT transfer management in nanomaterials and nanodevices (QUANTIHEAT)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2017,

The thermal properties of nanostructured materials are of fundamental importance to modern technology, but at present reproducible metrological definitions, tools and methods do not exist. This is because the mechanisms of heat transport at the nanoscale are entirely different to those at the macro scale.The project will place nanothermal metrology on a solid basis by an integrated physics-based e ...
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 23

 TERMINÉ 

Efficacy and safety of MRI-based thrombolysis in wake-up stroke: a randomised, double-blind, placebo-controlled trial (WAKE-UP)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2017,

WAKE-UP is an investigator-initiated, multicentre, randomised, double-blind, placebo-controlled trial designed to test efficacy and safety of MRI-based intravenous thrombolysis in patients with wake-up stroke. Every year 1.5 million patients suffer a stroke in the EU. Up to 20% of stroke patients wake up with stroke symptoms. Currently these patients are excluded from thrombolysis which is the onl ...
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 13

 TERMINÉ 

Transcribed-Ultraconserved Regions as novel biomarkers and therapeutic targets in liver cancer (LIVERNCODE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Hepatocellular carcinoma (HCC) is the sixth most common malignancy in the world. In Scotland incidence of liver cancer has increased of 60% in men from 2000 to 2010. The outcome of patients with advanced HCC remains poor. Thus, novel therapeutic approaches based on targeting oncogenic driver pathways in HCC are urgently needed, as well as informative prognostic markers that guide the use of existi ...
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 2

 TERMINÉ 

Multivessel versus culprit lesion only percutaneous revascularization in patients with acute myocardial infarction complicated by cardiogenic shock (CULPRIT-SHOCK)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) represents a major European health care concern with mortality rates between 40-70%. Approximately 70-80% of these patients present with multivessel disease defined as coronary lesions in more than one vessel. The clinician is faced with the decision to either 1) intervene only on the culprit lesion acutely responsible for the i ...
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 23

 TERMINÉ 

Suppression of Enzymes Required for Progression of LUng Cancer (SERPLUC)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

"Suppression of enzymes required for progression of lung cancer: we propose to combine an elegant genetically engineered mouse model (GEMM) of lung cancer with an in vivo RNAi screening approach in order to functionally identify a) biomarkers of early lung cancer development and b) candidate therapeutic targets whose activities are specifically required for the transition from benign to malignant ...
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 1

 TERMINÉ 

Interferometry beyond the Standard Quantum Limit using a Velocity Sensitive Sagnac Interferometer (SagnacSpeedmeter)

Date du début: 1 sept. 2012, Date de fin: 31 août 2017,

From the very first Michelson Interferometer invented over 100 years ago to today’s kilometre-scale gravitational wave detectors the sensitivity of interferometric length measurements has been improved by about 10 orders of magnitude and is now limited by the so-called Standard Quantum Limit (SQL), a manifestation of Heisenberg’s Uncertainty Principle. The SQL is comprised of the inevitable combin ...
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 1

 TERMINÉ 

Do oral contraceptives alter women’s mate preferences? (OCMATE)

Date du début: 1 juil. 2012, Date de fin: 30 juin 2017,

"Worldwide, ~100 million women use oral contraceptives (OCs). Discontinuation of OC use due to concerns about possible side effects is common among women who do not intend to become pregnant. Many recent studies have reported that women using OCs and women not using OCs have different mate preferences, raising the possibility that OCs alter mate preferences. Although these findings have been widel ...
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 2

 TERMINÉ 

The Fragments of the Republican Roman Orators (FRRO)

Date du début: 1 févr. 2012, Date de fin: 30 juin 2017,

This project gathers together, edits and interprets the surviving evidence for the orators of the Roman Republican period whose speeches do not survive in complete form. Its scope includes material which is, or is preserved as if it is, the actual words spoken by Republican orators as well as material about occasions when men spoke, who their audiences were, and the kinds of arguments they used in ...
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 1

 TERMINÉ 

Technology Options for Coupled Underground Coal Gasification and CO2 Capture and Storage (TOPS)

Date du début: 1 nov. 2013, Date de fin: 30 avr. 2017,

The main objective of the proposed project is to develop a generic UCG-CCS site characterisation workflow, and the accompanying technologies, which would address the dilemma faced by the proponents of reactor zone CO2 storage, and offer technological solutions to source sink mismatch issues that are likely to be faced in many coalfields. This objective will be achieved through integrated research ...
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 16

 TERMINÉ 

Social sensors for secUrity Assessments and Proactive EmeRgencies management (SUPER)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2017,

"Social media (SM) statistics during recent disasters (e.g., the 20 million tweets relating to «Sandy» storm and the sharing of related photos in Instagram at a rate of 10/sec) provide tangible evidence that security forces and civil protection agencies could greatly benefit from the effective blending of SM information into their processes. However, despite the widespread use of SM in various dom ...
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 11

 TERMINÉ 

ET-LCGT Telescopes: Exchange of Scientists (ELiTES)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

A new way to investigate the Universe will be possible when the new generation of gravitational wave telescopes becomes operative. First, the advanced detectors, then the 3rd generation observatories will allow to detect the gravitational wave signal emitted in catastrophic event in the Universe. The Large-scale Cryogenic Gravitational wave Telescope (LCGT, now named KAGRA) in Japan and the Einste ...
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 9

 TERMINÉ 

Adenovirus Vector Technology: Next Generation Systems for Medical Therapy (AD-VEC)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

We propose a programme (AD-VEC) involving two industrial and three academic partners with the aim to identify new adenoviral vectors as vehicles in novel medical applications for cardiovascular disease and infectious disease.This will be achieved through broad knowledge exchange between partners with complimentary and cutting edge technological and in-depth skills relating to adenovirus phylogeny, ...
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 6

 TERMINÉ 

GErmanium MId-infrared plasmoNIcs for sensing (GEMINI)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2017,

We aim at laying the foundations of a novel paradigm in optical sensing by introducing molecule-specific strong light-matter interaction at mid-infrared wavelengths through the engineering of plasmonic effects in group-IV semiconductors.The key enabling technology is the novel germanium-on-silicon material platform: heavily-doped Ge films display plasma frequencies in the mid-infrared range. This ...
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 4

 TERMINÉ 

European multicentre, randomised, phase III clinical trial of hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke (EuroHYP-1)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,

The consortium led by UKER and EuroHYP, the European Stroke Research Network for Hypothermia, proposes a large, multicentre clinical trial which will assess mild hypothermia as a novel treatment for ischemic stroke.Stroke is the second cause of death world-wide and the second cause of lost disability-adjusted life years in high-income countries. Stroke incidence rises exponentially with age, so it ...
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 38

 TERMINÉ 

Glioma Actively Personalized Vaccine Consortium (GAPVAC)

Date du début: 1 nov. 2012, Date de fin: 31 janv. 2017,

"Glioblastoma (GBM) is a rare (2-3 incidences in 100,000) and fatal disease. Each year, approximately 13,000 new cases of GBM are diagnosed in Europe. The 5-year survival rate of this highly aggressive tumor entity under conventional therapy is less than 6%. Currently available therapeutic options neglect the individuality of each patients’ disease and only temporarily influence tumor progression ...
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 13

 TERMINÉ 

Flare Chromospheres: Observations, Models and Archives (F-CHROMA)

Date du début: 24 sept. 2013, Date de fin: 1 janv. 2017,

We propose a focused space-based and ground-based multi-mode, multi-wavelength study of solar flares - the most intense energy release events in the solar system. We will center our attention on the flare chromosphere, from which most of the radiation originates. This work calls on space-based and ground-based observations, plus theoretical and modeling expertise. The project will have two major o ...
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 7

 TERMINÉ 

RADical reduction of OXidative stress in cardiovascular diseases (RADOX)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

Cardiovascular disease (CVD) constitutes a major and increasing health burden in developed countries. The prediction is that the prevalence of these conditions will increase by ~60% over the next 20 years. Therefore, the development of novel treatments for patients with CVD becomes more and more urgent. Oxidative stress is an important molecular contributor to the pathogenesis of CVD. However, ox ...
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 10

 TERMINÉ 

Flow in Transforming Porous Media (FlowTrans)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

The FlowTrans Initial Training Network is a unique environment for career development, built on joint challenges of Industry and University partners in a newly emerging supra-disciplinary field, spanning from Physics to Earth Sciences and aiming to understand Flow in Transforming Porous Media. Training will be hosted by 8 Universities in synergy with 2 full and 4 associated industry partners with ...
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 10

 TERMINÉ 

Regulating the Mitochondrial Decision to Die (ReMitoDed)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2016,

The mitochondrial pathway of apoptosis is the major form of programmed cell death in vertebrates. In this pathway, pro-apoptotic members of the Bcl-2 protein family cause mitochondrial outer membrane permeabilisation (MOMP) leading to the release of mitochondrial intermembrane space proteins that activate caspase proteases and apoptosis. Regulation of MOMP has been intensively investigated because ...
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 1

 TERMINÉ 

Genetic studies of pre-eclampsia in Central Asian and European populations (INTERPREGGEN)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2016,

Pre-eclampsia, one of the most dangerous cardiometabolic complications of pregnancy, claims the lives of 50,000 mothers and almost one million babies annually. Pre-eclampsia and other hypertensive disorders of pregnancy remain the second most common cause of maternal death. The incidence of pre-eclampsia in Central Asian countries is over twice as high as in western Europe. Inter-population differ ...
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 13

 TERMINÉ 

Compound Semiconductors for 3D integration (COMPOSE3)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2016,

COMPOSE3 aims to develop 3D stacked circuits in the front end of line of Complementary Metal Oxide Semiconductor (CMOS) technology, based on high mobility channel materials. The final objective is a 3D stacked SRAM cell, designed with gates length taken from the 14nm technology node. This technology will provide a new paradigm shift in density scaling combined with a dramatic increase in the power ...
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 10

 TERMINÉ 

Observational Prolonged Trial In Myotonic dystrophy type 1 to Improve QoL-Standards, a Target Identification Collaboration (OPTIMISTIC)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

OPTIMISTIC is a proposal for a European collaborative project of doctors, scientists, relevant stakeholders (TREAT-NMD, patient organizations) and SMEs with the aim to improve clinical practice for patients suffering from a rare, inherited, and neglected disease, myotonic dystrophy type 1 (DM1). It is one of the most variable human diseases with complex, multi-systemic and progressively worsening ...
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 9