2 projets européens trouvés
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TERMINÉ
"The NGF system and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generation drugs for neuropathic pain" (PAINCAGE)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2017,
"So far, there are no effective treatments for neuropathic pain (NP), and current treatments suffer from serious unwanted side effects.The NGF ligand-receptor system has recently emerged as a novel target for NP of great therapeutic potential, a master regulator, controlling both neuropathic and inflammatory components. Besides being a multi-component system, it also modulates the endocannabinoid ...
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TERMINÉ
The chronocircuitry of the hippocampus during cognitive behaviour (HIPPOCHRONOCIRCUITRY)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,
Neuronal activity of pyramidal cells in the CA1 area of the hippocampus enables spatial navigation, learning and memory and their firing is tightly controlled by GABAergic interneurons. Both, pyramidal cells and interneurons are highly heterogeneous cell types. Different CA1 pyramidal cells project to distinct brain areas including the subiculum, entorhinal, retrosplenial, prefrontal cortex, olfac ...
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