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A system view on the differential activities of human type I interferons (IFNaction)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,
Type I interferons (IFNs) form a restricted network of highly related immune cytokines that elicit differential biological responses through a single cell surface receptor comprised of the subunits IFNAR1 and IFNAR2. We have shown that differential signal activation correlates with differential interaction and conformational dynamics of the receptor induced by binding of different member of the IF ...
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