4 projets européens trouvés
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TERMINÉ
Advanced mass spectrometry approaches to reveal nucleic acid folding energy landscapes (DNAFOLDIMS)
Date du début: 1 juin 2014, Date de fin: 31 mai 2019,
"50 years after the discovery of the DNA double helix, the variety of structures that nucleic acids can adopt continues to surprise the scientific community. Specific structures and conformational changes are linked to important functions in cell regulation. Understanding the principles that govern how small molecules such as natural metabolites or synthetic drugs modulate the nucleic acid structu ...
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1
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TERMINÉ
Translational Regulation of Gene Expression by the Nascent Polypeptide Chain (TRANSARREST)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,
Following initiation of protein synthesis, the nascent polypeptide must journey through the exit tunnel of the ribosome. Although this has typically been deemed a passive process, it is established that certain peptide sequences interact with rRNA components and ribosomal proteins lining the walls of the tunnel to bring protein synthesis to a complete halt. In many cases, translational arrest is d ...
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1
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TERMINÉ
Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - The FRAILOMIC Initiative (FRAILOMIC)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
The forecasted increase in the number of older people for this century will be accompanied by an increase of those with disabilities. Disability is usually preceded by a condition named frailty that encompasses changes associated with ageing, life styles and chronic diseases. To detect and intervene on it is of outstanding importance to prevent disability, as recovery from disability is unlikely. ...
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29
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TERMINÉ
"The NGF system and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generation drugs for neuropathic pain" (PAINCAGE)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2017,
"So far, there are no effective treatments for neuropathic pain (NP), and current treatments suffer from serious unwanted side effects.The NGF ligand-receptor system has recently emerged as a novel target for NP of great therapeutic potential, a master regulator, controlling both neuropathic and inflammatory components. Besides being a multi-component system, it also modulates the endocannabinoid ...
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