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21 projets européens trouvés

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 TERMINÉ 

Support for international rare disease research to serve the IRDiRC objectives (SUPPORT-IRDiRC)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2018,

Research into rare diseases (RD) is badly needed as many patients still lack a proper diagnosis and most of them are left without an effective treatment. In addition, research in this area is very relevant from a scientific point of view as RD are model diseases for more common disorders and are strong drivers of innovation. However, research in this field faces some specific constraints stemming ...
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 2

 TERMINÉ 

Membranous nephropathy : a model for solving organ-specific auto-immunity (OSAI) (OSAI)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,

"Membranous nephropathy (MN) is a paradigm of organ-specific autoimmune disease which affects the kidney glomerulus, resulting in the formation of immune deposits, complement-mediated proteinuria, and renal failure. My group has recently identified 2 causative antigens (neutral endopeptidase and bovine serum albumin) in children, and 2 predisposing genes HLA-DQA1 and PLA2R1 coding for another anti ...
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 1

 TERMINÉ 

Biomarker Research Alliance for Diagnosing Heart Disease in the Ageing European Population (BESTAGEING)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,

The ageing of the European population represents a rapidly rising social and economic challenge. Especially cardiovascular morbidity increases with age, but unfortunately, elderly patients are often difficult to diagnose due to confounding factors, leading to uncertainties in clinical decision making with huge impact on patients’ outcomes. Hence, there is an unmet need for novel biomarkers for mor ...
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 22

 TERMINÉ 

Pathogen COinfection: HIV, Tuberculosis, Malaria and Hepatitis C virus (PathCO)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

Acquired immune deficiency (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. In addition to these pathogens, 170 million people are infected with hepatitis C virus (HCV), which leads to chronic liver disease. Because of shared routes of transmission, HCV co-infection is recognized as a major cause of morbidity and mortality among HIV-1 infected per ...
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 11

 TERMINÉ 

Bacterial host cell death modulators – a genetic approach to identify anti-apoptotic factors of Chlamydia trachomatis and to explore their role during infection (GenChlaDeath)

Date du début: 1 oct. 2014, Date de fin: 30 sept. 2017,

Chlamydia trachomatis is a leading cause of sexually transmitted disease - with reported prevalence rates of up to 17% among asymptomatic women in Europe - and as such a frequent cause of infertility. While these bacteria have been known for more than a decade to protect infected cells from apoptosis, the lack of tools for genetic manipulation of chlamydiae significantly hampered the investigation ...
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 1

 TERMINÉ 

Integrated European –omics research project for diagnosis and therapy in rare neuromuscular and neurodegenerative diseases (Neuromics)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

Neurodegenerative (ND) and neuromuscular (NM) disease is one of the most frequent classes of rare diseases, affecting life and mobility of 500,000 patients in Europe and millions of their caregivers, family members and employers. This NEUROMICS project brings together the leading research groups in Europe, five highly innovative SMEs and relevant oversea experts using the most sophisticated Omics ...
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 20

 TERMINÉ 

Predictive Position Coding (POSITION)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Vision gives us enormous adaptive advantage because it allows us to see and react to events before they reach us. This predictive advantage is most obvious for an object in motion where the current trajectory predicts future location. It is equally important when the object’s motion results from the movement of our own eyes. Here our visual system uses knowledge about the upcoming motion of the ey ...
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 2

 TERMINÉ 

Innovative methodology for small populations research (InSPiRe)

Date du début: 1 févr. 2014, Date de fin: 31 mai 2017,

The HEALTH.2013.4.2-3 call identifies a need for new or improved statistical methodology for clinical trials for the efficient assessment of safety and/or efficacy of treatment for small population groups. This project brings together international experts in innovative clinical trial design methodology in these specific areas along with key stakeholders including regulatory authorities, industry ...
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 9

 TERMINÉ 

Study of the molecular and cellular mechanisms of incentive learning (SMILE)

Date du début: 1 juin 2010, Date de fin: 31 mai 2016,

"Incentive learning is a universal mechanism by which animals and humans learn rewarding behavioral responses. Its diversion towards the wrong targets is involved in human conditions ranging from drug addiction to pathological gambling and obesity. Incentive learning has been studied from a behavioral standpoint and only few of the underlying molecular mechanisms have been identified. We propose i ...
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 1

 TERMINÉ 

Fast Mapping: How to acquire new declarative memories independently from the Hippocampus? (FAST MAPPING)

Date du début: 1 oct. 2012, Date de fin: 11 mai 2016,

Current theories of declarative memory suggest that it is supported by two complementary memory systems: the medial temporal lobe (MTL) which specializes in rapid acquisition of novel associations and the neocortex, which slowly learns through environmental regularities. Gilboa et al. recently reported an extraordinary phenomenon of rapid acquisition of novel arbitrary associations by adults with ...
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 1

 TERMINÉ 

Studying Physiology and Pathology of Imprinted Genes to understand the role of Epigenetic Mutations in Human Disease (INGENIUM)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,

"The aim of this ITN is to promote research and training in the field of epigenetics associated with human disease. Expression of imprinted genes is mono-allelic and gamete of origin-dependent. This is due to different epigenetic modifications present on the maternal and paternal chromosomes. Failure in normal establishment, maintenance or erasure of these marks results in gene dosage dysregulatio ...
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 10

 TERMINÉ 

Regulation of stage conversion in the malaria parasite: molecular insights for novel vaccine strategies (STACOMAL)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,

Infection of the liver by Plasmodium parasites, the causative agents of malaria, is an essential and clinically silent phase that constitutes an ideal target for anti-malarial prophylactic approaches such as vaccines. After inoculation in the skin by a mosquito, Plasmodium sporozoites migrate to the liver and invade hepatocytes, where they differentiate into liver stages and thousands of pathogeni ...
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 1

 TERMINÉ 

Network of European funding for Neuroscience research (ERA-NET NEURON II)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

Research into the human brain and its diseases is one of the key challenges of our century, since among the many diseases affecting health, disorders of the brain are major causes for impaired quality of life. Despite some progress in understanding the molecular mechanisms of the various neurological and psychiatric disorders, research is far from being able to offer solutions how to conquer them ...
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 24

 TERMINÉ 

NPlast - A neuroscience school that aims to preserve and restore neuroplasticity in brain disorders (NPLAST)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

Brain disorders impose an increasing economical and social burden in the member states of the European Union (EU). For most neurodegenerative diseases and many neuropsychiatric disorders no efficient treatment is available and no cure exists. In the next coming years the number of particularly elderly people suffering from brain disorders will tremendously increase. Predictions from the turn of th ...
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 10

 TERMINÉ 

CEREBELLUM IN VISUALSPATIAL ORIENTATION (CERVISO)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

The Cerebellum in visual-spatial orientation (CERVISO) is inter-disciplinary, exchange program uses original and innovative research methods to investigate the role of cerebellum in optimization of motor control and spatial orientation. Toward this objective we will identify patterns of cerebellar functions using the saccadic eye movement model. We will study visual spatial exploration in normal s ...
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 3

 TERMINÉ 

Automatic detection and monitoring of consciousness (COMONIN)

Date du début: 1 mars 2014, Date de fin: 31 août 2015,

When patients recover from coma, determining their level of consciousness can be difficult, even for an experienced clinician. Our goal is to provide a Consciousness Monitoring Index: a robust method to detect and quantitatively monitor the extent to which a human being is or is not conscious. Using electrodes attached to the scalp, we monitor the electro-encephalographic (EEG) signal which reflec ...
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 2

 TERMINÉ 

Semantic integrAtion and reasoning Framework for pharmacovigilancE signals Research (SAFER)

Date du début: 1 juil. 2013, Date de fin: 30 juin 2015,

Adverse drug effects endanger patients’ safety and cause considerable extra healthcare costs. The procedures of drug surveillance and drug harm prevention are studied by pharmacovigilance. Several Information Technology (IT) methods are currently employed for conducting research as regards identification of pharmacovigilance signals. The current project (SAFER) will elaborate on exploiting and com ...
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 1

 TERMINÉ 

Semantic Interoperability for Health Network (SemanticHealthNet)

Date du début: 1 déc. 2011, Date de fin: 31 mai 2015,

SemanticHealthNet will develop a scalable and sustainable pan-European organisational and governance process for the semantic interoperability of clinical and biomedical knowledge, to help ensure that EHR systems are optimised for patient care, public health and clinical research across healthcare systems and institutions.Through a clinically-driven workplan, exemplified in cardiovascular medicine ...
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 18

 TERMINÉ 

"Myasthenias, a group of immune mediated neurological diseases: from etiology to therapy." (FIGHT-MG)

Date du début: 1 déc. 2009, Date de fin: 31 mai 2014,

"Myasthenia Gravis (MG) is a heterogeneous rare autoimmune neurological disease affecting the neuromuscular junction (NMJ). The molecular events causing and maintaining MG are still unknown and current treatments do not lead to remission and entail considerable side-effects stressing the need for improved therapies. We will address the: 1. Natural course of disease: determine factors associated wi ...
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 13

 TERMINÉ 

INtegrated HEart Research In TrANslational genetics of dilated Cardiomyopathies in Europe (INHERITANCE)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2013,

"Inherited dilated cardiomyopathies (DCM) are monogenic disorders caused by mutations in more than 30 genes, characterised by substantial phenotype heterogeneity. DCM affects 1:2.500 individuals and is the major cause of heart transplantation and death for non-ischaemic heart failure in adolescents and young adults. Currently, less than 1% of patients with familial DCM are genotyped in Europe. The ...
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 11

 TERMINÉ 

Subretinal Microglia accumulation play a decisive role in the development of Age-related Macular Degeneration (Microglia and AMD)

Date du début: 1 sept. 2008, Date de fin: 31 août 2013,

Age-related macular degeneration (AMD) is the leading cause of vision loss in the Europe. New anti-angiogenic therapies of AMD do not treat the neurodegenerative aspect of AMD. Recent evidence suggests an implication of inflammatory mediators in AMD. We have focused our interest on the potential role of chemokines (Ch) and microglial cells (MC) in this condition. Our data concerning the chemokine ...
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 1