9 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Mitochondrial Medicine: developing treatments of OXPHOS-defects in recombinant mammalian models (MITCARE)
Date du début: 1 juil. 2013, Date de fin: 30 juin 2018,
Mitochondria are the major source of ATP, synthesized by the mitochondrial respiratory chain (MRC) through the process of oxidative phosphorylation. ATP deficiency leads to cellular dysfunction and ultimately death. In mammals, 13 mitochondrial DNA (mtDNA)-encoded subunits interact with over 70 nuclear-encoded subunits to form four of the five MRC complexes. Many additional factors are essential f ...
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3
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TERMINÉ
The analysis of mitochondrial dynamics in ageing and neurodegeneration (DYNAMITO)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
The survival of our most active tissues, such as the brain and heart, throughout decades of a human lifespan presents an extraordinary biological challenge. Mitochondria are central to the life and death of these tissues. They provide the cellular energy required by these cells and protect them by buffering potentially lethal levels of cytoplasmic calcium, while at the same time mitochondria produ ...
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2
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TERMINÉ
Materials’ Innovations for a Safe and Sustainable nuclear in Europe (MATISSE)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
The European Energy Research Alliance, set-up under the European Strategic Energy Technology Plan, has launched an initiative for a Joint Programme on Nuclear Materials (JPNM). The JPNM aims at establishing key priorities in the area of advanced nuclear materials, identifying funding opportunities and harmonizing this scientific & technical domain at the European level by maximizing complementarit ...
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32
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TERMINÉ
High throughput integrated technologies for multimaterial functional Micro Components (HINMICO)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,
Volume production at industrial scale of miniaturised multi-material 3D (polymer-polymer, metal-polymer, metal-metal, polymer-ceramics,...) still face important challenges to be affordable by SMEs. Challenges not only in terms of precision manufacturing (precision engineering
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16
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TERMINÉ
Multiwavelength cell spectroscopy to define the pathophysiology of mitochondrial disorders in living cells (CELLSPEX)
Date du début: 1 mars 2014, Date de fin: 29 févr. 2016,
Mitochondria are the powerhouses of eukaryotic cells. Through oxidative phosphorylation (OxPhos), mitochondria extract energy from nutrients and use it to transfer protons across a proton-impermeable membrane creating a proton motive force to drive ATP production. Since the enzymes that catalyse OxPhos are encoded in both the mitochondrial and nuclear genomes, mutations in either one can cause mit ...
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1
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TERMINÉ
Elucidating the Roles of Proteins of Mitochondrial DNA Maintenance (Mitoskeleton)
Date du début: 1 juin 2011, Date de fin: 1 juil. 2014,
Mitochondrial DNA defects were established as a cause of human disease over 20 years ago, and they are increasingly recognized as a contributory factor in major causes of human morbidity, such as neurodegeneration. Although mitochondrial DNA is known to be packaged with a variety of proteins, their functions are in many cases ill defined; hence this field is in its infancy. The functional characte ...
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1
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TERMINÉ
Development of new light high-performance environmentally benign composites made of bio-materials and bio-resins for electric car application (ECOSHELL)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2013,
"ECOSHELL is concerned with the development of optimal structural solutions for superlight electric vehicles (category L6 and L7e), decreasing its environmental footprint and using an innovative bio-composite material for the vehicle body. Traditionally this category of urban vehicles has been relatively expensive and lacking of sufficient security measures compared to a classic vehicle (category ...
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12
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TERMINÉ
EUROPEAN DRUG INITIATIVE ON CHANNELS AND TRANSPORTERS (EDICT)
Date du début: 1 févr. 2008, Date de fin: 30 juin 2012,
"The European Drug Initiative on Channels and Transporters, EDICT, allies for the first time, partners with world-class expertise in both the structural and functional characterisation of membrane channels and transporters. State-of-the-art facilities and personnel for X-ray crystallography, Electron Microscopy and Nuclear Magnetic Resonance and the latest throughput technology, will provide infra ...
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28
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TERMINÉ
The Molecular Basis of Mitochondrial Disease: Elucidating the Function of the Mitochondrial Inner Membrane Protein MPV17 (MDS)
Date du début: 1 mai 2010, Date de fin: 30 avr. 2012,
"Mitochondria contain their own DNA (mtDNA), which contributes essential components of the energy generating system of the organelle. Because mtDNA requires many nuclear gene products for its maintenance and expression, nuclear gene defects can lead to mtDNA loss. MPV17 is one such gene, pathological mutations in MPV17 were identified by the researcher as a cause of mtDNA loss, yet the function of ...
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