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18 projets européens trouvés

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 TERMINÉ 

Structural basis of mitochondrial inner membrane shape and dynamic (MitoShape)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,

Here, I propose to study the structure and mechanisms of the cellular machineries mediating the shape and dynamics of the mitochondrial inner membrane (IM). The mitochondrial IM contains membrane invaginations called cristae. These are connected by tubular openings, the crista junctions, to the remaining IM. Mitochondrial shape constantly changes due to membrane fission and fusion events, and a ba ...
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 1

 TERMINÉ 

METABOLIC BASIS OF NEURODEGENERATIVE DISEASE (BeyOND)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Alzheimer disease (AD) is the most common form of age-related dementia affecting millions of patients worldwide. Disturbingly, disorders of lipid and glucose metabolism emerge as major risk factors for onset and progression of neurodegeneration in the human population. Thus, an increasing life expectance combined with an observable rise in metabolic disturbances is expected to turn AD into one of ...
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 1

 TERMINÉ 

Biomarker Development for Postoperative Cognitive Impairment in the Elderly (BioCog)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Postoperative delirium (POD) is characterized by the progressive deterioration of sensory/cognitive function after surgery with incidences of up to 30-80%. It is frequently followed by postoperative cognitive dysfunction (POCD) which tends to persist over time. In elderly patients, POCD resembles chronic dementia and appears to accelerate the cognitive decline in Alzheimer dementia. POD is strongl ...
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 12

 TERMINÉ 

Dissecting the mechanisms of miRNA function (miRfunction)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,

miRNAs are crucial regulators of gene expression that target more than half of eukaryotic genes and play a role in human diseases, including cancer and neurological disorders. Therefore, it is important to understand the molecular mechanisms underlying miRNA-mediated repression. miRNAs act as guides recognizing their target mRNAs by partial complementarity and recruiting a complex of proteins that ...
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 1

 TERMINÉ 

Impact of stress-induced transposon activities on human disease (TRANSPOSOstress)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The evolutionary success of transposable elements (TEs) is underscored by the finding that about 45% of the human genome is TE-derived. However, recent high throughput approach studies indicate that the impact of TE-associated activities was seriously underestimated. The first objective is to investigate the impact of TE-derived activities on the human genome in general and on disease mechanisms i ...
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 1

 TERMINÉ 

The European non-coding RNA network (RNATRAIN)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

"Non-coding RNA (ncRNA) is a new research field in rapid development. It holds the potential to explain many fundamental biological phenomena and there is a vast prospective for the development of ncRNA-derived diagnostic and therapeutic tools. Hence, biotech and pharmaceutical companies are actively looking into this unexplored territory for novel targets. Therefore, there is a substantial and un ...
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 11

 TERMINÉ 

A systems and targeted approach to alternative splicing in the developing and diseased heart: Translating basic cell biology to improved cardiac function (CARDIOSPLICE)

Date du début: 1 janv. 2012, Date de fin: 30 juin 2017,

Cardiovascular disease keeps the top spot in mortality statistics in Europe with 2 million deaths annually and although prevention and therapy have continuously been improved, the prevalence of heart failure continues to rise. While contractile (systolic) dysfunction is readily accessible to pharmacological treatment, there is a lack of therapeutic options for reduced ventricular filling (diastoli ...
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 1

 TERMINÉ 

Molecular exploitation of an extremophile mammal (EXTREMOPHILE MAMMAL)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,

"The African naked mole-rat (Heterocephalus glaber) is an unusual rodent species that has evolved physiological strategies to adapt to an extreme ecological niche. It is the only poikilothermic mammal (cold-blooded), has an extraordinarily long life span for its small size (in excess of 30 years) and lives in large colonies organized like those of termites (eusocial). We have shown that naked mole ...
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 1

 TERMINÉ 

Characterization of direct reprogramming-regulating factors LIN-53 and USP-48 (REPROL53U48)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,

"Cellular replacement therapies for treating degenerative diseases such as Alzheimer’s will require the generation of lost tissues by reprogramming cell types. While one strategy is to de-differentiate somatic cells into induced pluripotent stem cells with subsequent re-differentiation, an alternative strategy is to directly convert cells to the target cell type by using specific Transcription Fac ...
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 1

 TERMINÉ 

Modeling lymphoma pathogenesis in mice - from basic mechanisms to pre-clinical models (LYMPHOMA)

Date du début: 1 juil. 2011, Date de fin: 31 déc. 2016,

Human B cell lymphomas including multiple myeloma and Hodgkin¿s disease are frequent malignancies and a major clinical problem. Their high incidence is due to special features of normal B cell development that promote chromosomal translocations and other genetic alterations. Another contributing factor is Epstein-Barr-Virus (EBV), a B cell-transforming virus endemic in humans. EBV-infected cells a ...
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 1

 TERMINÉ 

Dynamic Signal Transduction in Individual Cells (DYNASTIIC)

Date du début: 1 août 2012, Date de fin: 31 juil. 2016,

Regulation of proliferation and differentiation is a fundamental challenge for multicellular organisms. The decision between alternative cell fates is therefore tightly controlled by cellular signaling. During the past decades, the central components of the signaling machinery have been identified. The challenge we are facing now is to understand how signaling networks act dynamically in living ce ...
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 2

 TERMINÉ 

Wnt/calcium signaling in cardiovascular development (WNT/CALCIUM IN HEART)

Date du début: 1 août 2012, Date de fin: 31 juil. 2016,

While much is known about genetically encoded developmental pathways, the mechanisms by which the electrochemical cues interact with traditional morphogenetic pathways during embryogenesis are poorly understood. The central idea of the proposed research is to understand the interplay between major signaling pathway and electrochemical cues during embryogenesis as well as in disease. We have develo ...
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 1

 TERMINÉ 

Brain states, synapses and behaviour (BRAINSTATES)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2016,

Global changes in patterns of neuronal activity or brain state are the first phenomenon recorded in the awake human brain (1). Changes in brain state are present in recordings of neocortical activity from mouse to man. It is now thought that changes in brain state are fundamental to normal brain function and neuronal computation. Despite their importance, we have very little idea about the under ...
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 1

 TERMINÉ 

Molecular Mechanisms Regulating Pancreatic Islet Vascularization (ISLETVASC)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2015,

Many reports indicate the number of people with diabetes will exceed 350 million by the year 2030. Both type 1 and type 2 diabetes are characterized by the deterioration and impaired function of pancreatic b-cells. While transplantation is a promising strategy to replace lost tissue, several obstacles remain in the pathway to its clinical application. Whether b-cells are derived from patient sampl ...
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 1

 TERMINÉ 

Infrastructure for Systems Biology - Europe (ISBE)

Date du début: 1 août 2012, Date de fin: 31 juil. 2015,

The Infrastructure for Systems Biology in Europe (ISBE) programme comprises an infrastructure that is designed to meet the needs of European systems biology, in terms of development, applications and training. In order to address this requirement, we are proposing a distributed, interconnected infrastructure which primarily comprises three types of centres: Data Integration Centres (DICs), and sys ...
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 24

 TERMINÉ 

Condition specific RNA Regulatory Maps (RNARegMap)

Date du début: 1 juin 2013, Date de fin: 31 mai 2015,

RNA-binding proteins (RBPs) regulate the processing and expression of protein-coding transcripts. The goal of the proposed research is to develop a strategy to determine specific mRNA regulatory factors and elements important for investigating any biological processes. First, we will construct a transcriptome-wide post-transcriptional regulatory map of RBP-mRNA interactions by probabilistic modeli ...
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 1

 TERMINÉ 

MECHANISMS UNDERLYING CELL FATE DECISION BETWEEN PANCREAS AND LIVER (HEPATOPANCREATIC)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2014,

"Diabetes is a degenerative disease affecting millions of persons worldwide. A cure for diabetes depends on replacing the insulin-producing ²-cells in the pancreas that are destroyed by the disease. An attractive strategy to attain this goal is to convert liver adult cells of the same patient into pancreatic ²-cells. The liver and pancreas share many aspects of their early development and are spec ...
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 1

 TERMINÉ 

Global characterization of post-transcriptional regulatory interactions in DNA damage response (PostScribeDNAdamage)

Date du début: 1 juil. 2012, Date de fin: 30 juin 2014,

"The proposed project aims to identify the dynamics of RNA-protein interactions during DNA damage response (DDR) using high-throughput “omics” approaches.The mechanistic basis of DDR has been classically thought to consist of an ""early"" post-translational response, which results in activation of several signalling pathways and transciption factors. These activate the ""late"" transcriptional rep ...
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 1