15 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Synergy and antagonism of cholinergic and dopaminergic systems in associative learning (CholAminCo)
Date du début: 1 mai 2017, Date de fin: 30 avr. 2022,
Neuromodulators such as acetylcholine and dopamine are able to rapidly reprogram neuronal information processing and dynamically change brain states. Degeneration or dysfunction of cholinergic and dopaminergic neurons can lead to neuropsychiatric conditions like schizophrenia and addiction or cognitive diseases such as Alzheimer’s. Neuromodulatory systems control overlapping cognitive processes an ...
Voir le projet
1
Participant partenaire
TERMINÉ
Restoration of visual perception by artificial stimulation performed by 3D EAO microscopy (VISONby3DSTIM)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
The long-term aim of the investigation is to assess the feasibility of creating an “artificial sense” and, thereby, a possible sensory (visual) prosthetic. While working towards this goal, we will have to address the question of how neural assembly activity relates to subjective perceptions. Finding and understanding these functional assemblies will make it possible to reactivate them in a precise ...
Voir le projet
1
Participant partenaire
TERMINÉ
Resetting the THYRoid axis for prevention of AGE-related diseases and co-morbidities (THYRAGE)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
We hypothesize that inappropriate thyroid hormone action in target cells is a common mechanism underlying susceptibility to age-related degenerative diseases and co-morbidities. Although regulation of systemic thyroid status is well understood and underpins treatment of common thyroid disease, it is only in the last decade that the importance of local regulation of thyroid hormone action in tissue ...
Voir le projet
7
Participants partenaires
TERMINÉ
Deciphering the cholinergic modulation of the hippocampal place code. (HippAchoMod)
Date du début: 8 août 2016, Date de fin: 7 août 2019,
... in the proposal I will be acquainted with the cutting edge technologies as well as skills indispensable for starting my independent research group and expanding the research potential of my home institute.
Voir le projet
1
Participant partenaire
TERMINÉ
Human Brain Project Specific Grant Agreement 1 (HBP SGA1)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,
Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses I ...
Voir le projet
126
Participants partenaires
TERMINÉ
Modulation of cortical activity by median raphe neuronal assemblies with identified behavioural effects (SERRACO)
Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,
"Cortical operations are built up from states associated with distinct behaviour-dependent network activity patterns that subserve information aquisition, encoding, memory consolidation and retrieval. Thus, they can be considered as manifestations of different processing modes. Groups of modulatory, largely monoaminergic neurons located in subcortical nuclei innervating all forebrain areas are ind ...
Voir le projet
1
Participant partenaire
TERMINÉ
Quantitative Molecular Map of the Neuronal Surface (MolecMap)
Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,
The most fundamental roles of nerve cells are the detection of chemical neurotransmitters to generate synaptic potentials; the summation of these potentials to create their output signals; and the consequent release of their own neurotransmitter molecules. All of these functions require the orchestrated work of hundreds of molecules targeted to specialized regions of the cells. In nerve cells, m ...
Voir le projet
1
Participant partenaire
TERMINÉ
The Human Brain Project (HBP)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,
...imulation, High Performance Computing, Medical Informatics, Neuromorphic Computing and Neurorobotics, and create a user community of research groups from within and outside the HBP, set up a European Institute for Theoretical Neuroscience, complete a set of pilot projects providing a first demonstration of the scientific value of the platforms and the Institute, develop the scientific and technolo ...
Voir le projet
116
Participants partenaires
TERMINÉ
The role of the basal forebrain in attention and learning (NBATTENTION)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2015,
The basal forebrain (BF) constitutes a major neuromodulatory center, providing extensive projections to the entire forebrain, including all of cortex. Mounting evidence demonstrates that these projections play a key role in cognitive functions, including learning and attention. Damage or deterioration of BF in humans leads to severe cognitive impairments, such as dementia and executive dysfunction ...
Voir le projet
1
Participant partenaire
TERMINÉ
Switchbox: Maintaining health in old age through homeostasis (SWITCHBOX)
Date du début: 1 févr. 2011, Date de fin: 31 juil. 2015,
Healthy aging requires maintenance of homeostatic control of the physiological systems and functions that are integrated by the hypothalamus. Driven by work in previous EU projects (Crescendo/Lifespan) highlighting insulin signalling and the hypothalamic/pituitary/adrenal and thyroid axes in the regulation of aging, SWITCHBOX will examine the flexibility of these neuroendocrine systems in response ...
Voir le projet
6
Participants partenaires
TERMINÉ
The Integrated Neurobiology of Food Intake, Addiction and Stress (NEUROFAST)
Date du début: 1 avr. 2010, Date de fin: 31 mars 2015,
NeuroFAST is a multidisciplinary project, involving ten teams from seven countries, to explore the neurobiology of addiction and eating behaviour and the complex socio-psychological forces that can lead to its dysregulation. These forces include dietary components (including highly palatable foods and alcohol), some of which may have addictive properties, but also cultural and social pressures, ev ...
Voir le projet
13
Participants partenaires
TERMINÉ
Nanotechnology: Training Of Experts in Safety (NANOTOES)
Date du début: 1 nov. 2010, Date de fin: 28 févr. 2015,
Life Sciences and Nano Sciences interact today mainly in two areas: in the evaluation of accidental health and environmental effects derived from engineered nanomaterials, and in development and biological/clinical evaluation of nanoparticles with intended biological effects for application in medicine and biotechnology. It is essential for producers, distributors, consumers and regulators that th ...
Voir le projet
12
Participants partenaires
TERMINÉ
Understanding the molecular blueprint and functional complexity of the endocannabinoid metabolome in the brain (BRAINCANNABINOIDS)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2014,
We and others have recently delineated the molecular architecture of a new feedback pathway in brain synapses, which operates as a synaptic circuit breaker. This pathway is supposed to use a group of lipid messengers as retrograde synaptic signals, the so-called endocannabinoids. Although heterogeneous in their chemical structures, these molecules along with the psychoactive compound in cannabis a ...
Voir le projet
1
Participant partenaire
TERMINÉ
Adenosine receptors in diabetes (HASKODIABETES)
Date du début: 1 avr. 2008, Date de fin: 31 mars 2011,
"Adenosine receptors are expressed on immune cells and other tissues thought to regulate inflammatory events in mammals. Adenosine receptors, when activated by endogenous ligands or exogenous analogs, may repress inflammatory and immune pathways that lead to the destruction of pancreatic islets in models of type I diabetes and islet graft rejection. Building on our observations that inosine and NE ...
Voir le projet
1
Participant partenaire
TERMINÉ
1. Reason for the project: In an increasingly global, knowledge−based economy, the need for a greater understanding of Intellectual Property management is crucial for business success. Many sources, including the World Intellectual Property Organization (WIPO) recognize that the increasing contribution to research and innovation from SMEs is not matched by a widespread awareness of the IP system, ...
Voir le projet