2 projets européens trouvés
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TERMINÉ
Understanding and combating human age-related muscle weakness (MYOAGE)
Date du début: 1 janv. 2009, Date de fin: 30 juin 2013,
Ageing of skeletal muscle results in a progressive loss of mobility that decreases the quality of life and has major economic and social consequences for society at large. Increasing muscle weakness is a major component of muscle ageing. In the elderly muscles become atrophic (loss in muscle mass) and weaker (loss in muscle force), more susceptible to damage and consequently regenerate and recover ...
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TERMINÉ
Regulation of obesity and fatty acid-induced inflammation by AMP-activated protein kinase in obese/type 2 diabetic and inactive human skeletal muscle (AMPKANTIINFLAMMATION)
Date du début: 8 juil. 2011, Date de fin: 7 janv. 2013,
It is increasingly recognised that obesity is characterised by chronic activation of inflammatory pathways in skeletal muscle and that this is a causative factor of obesity associated insulin resistance; also contributing to the pathogenesis of complications of diabetes. My work has shown that activation of AMP-activated protein kinase (AMPK) can regulate inflammatory signalling by antagonising fa ...
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