7 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Validating predictive models of radiotherapy toxicity to improve quality-of-life and reduce side-effects in cancer survivors (REQUITE)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
...apy impact on the quality-of-life (QoL) of cancer survivors. These side-effects could be reduced if predicted in advance. Previous work identified clinical and biological predictors but a major, coordinated approach is needed to validate them so they can be used clinically. The EU has ~17.8 million people living with a prior diagnosis of cancer of whom ~7 million received radiotherapy. In the long ...
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15
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TERMINÉ
Mechanisms of Mismatch repair inactivation and identification of genes suppressing mutations (iMMR)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2018,
...ore the stability of the genome, relies on the DNA Mismatch repair (MMR) pathway, which recognizes DNA replication errors and promotes repair by an excision and re-synthesis mechanism. Mutations that inactivate MMR are associated to Lynch Syndrome, an early-onset cancer disorder characterized by accumulation of mutations at repetitive sequences or microsatellite instability (MSI). Interestingly, a ...
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1
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TERMINÉ
Defining the Impact of Chromosome Instability in Tumor Initiation, Maintenance and Relapse (MADCIN)
Date du début: 1 févr. 2012, Date de fin: 31 janv. 2018,
Chromosomal instability (CIN), the inability to correctly segregate sister chromatids during mitosis, is a hallmark of cancer cells. Overexpression of the mitotic checkpoint protein Mad2, commonly found in human tumors, leads to CIN and the development of aneuploid tumors in mouse models. However, recent observations from various laboratories suggest that aneuploidy can promote or suppress tumorig ...
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2
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TERMINÉ
Unlocking the potential of ultra-high-field MRI through manipulation of radiofrequency excitation fields in human tissue (MRexcite)
Date du début: 1 mai 2012, Date de fin: 30 avr. 2017,
... often counteracted by these unresolved technical hurdles. 7T MRI cannot be considered for routine clinical use or even effectively evaluated for such use until these hurdles have been overcome.Preliminary research indicates that these effects can be addressed by use of parallel transmission strategies. The goal of the proposed project is to develop a highly optimized multi-channel transmit/receiv ...
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2
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TERMINÉ
Identifying and characterising transmembrane transporters of tryptophan and kynurenine in normal and cancerous brain tissue (KP Transport)
Date du début: 1 sept. 2014, Date de fin: 31 août 2016,
The catabolism of the essential amino acid tryptophan (Trp) by tumour cells expressing either IDO1/2 or TDO has been associated with malignant tumour progression and poor patient survival. Expression of these rate-limiting genes leads to both depletion of Trp and accumulation of the Trp breakdown product kynurenine (Kyn) in the tumour microenvironment. Kyn has recently been shown to act as a lig ...
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1
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TERMINÉ
Recruitment and activation of brown adipocytes as preventive and curative therapy for type 2 diabetes (DIABAT)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,
"The DIABAT project will employ knowledge of the function, dysfunction and physiological regulation of brown adipocytes to develop innovative therapeutic and preventive strategies for type 2 diabetes. Brown adipose tissue (BAT) is currently a worldwide recognized target to combat obesity and diabetes due to last years re-discovery of functional BAT in adult humans by several of the members of the ...
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22
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TERMINÉ
Regulation of Argonaute-2 and miRNA-dependent mRNA decay in response to oxidative stress and DNA damage (mirnaAGOddr)
Date du début: 7 mars 2012, Date de fin: 6 mars 2014,
Cells respond to extracellular stress by inducing specific intracellular programs through the activation of stress kinase signalling pathways. Stress responses are associated with the phosphorylation of particular substrates implicated in restoring homeostasis and cell integrity. Oncogene activation has also been shown to generate replicative DNA damage, activate the DNA Damage Response (DDR) and ...
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