3 projets européens trouvés
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TERMINÉ
Assembling genome history from gene stories: Phylogeny aware genome scale inference of ancestral traits and ancient environments (GENESTORY)
Date du début: 1 juil. 2013, Date de fin: 31 déc. 2016,
"Using genomic data to understand how system-level traits of living organisms have been shaped by past environments and to disclose information on ancient environments and diversity are key issues of contemporary biology. Genome sequences that encode the complex networks underlying modern life and concealing the vast intricate record of the evolutionary history of their carriers are available. Mod ...
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TERMINÉ
Modulation of CFTR stability and function from the extracellular space (Loop ABC)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2012,
The CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) is a unique ABC protein functioning as a chloride channel. It consists of two transmembrane and two nucleotide binding domains, and a regulatory region. The cftr gene is mutated in cystic fibrosis, an inherited disease of high morbidity and mortality mostly affecting people with European ancestors. So far more than 1,500 mutations are ...
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TERMINÉ
Quantum chemical and combined quantum mechanical/molecular mechanical (QM/MM) modelling of oestrogen biosynthesis and metabolism (OestroMetab)
Date du début: 1 oct. 2009, Date de fin: 29 sept. 2012,
The aim of the research proposal is to study the biosynthesis and metabolism of oestrogen derivatives with state-of-the-art quantum mechanical (QM) and combined quantum mechanics molecular mechanics (QM/MM) calculations. Oestrogens play a manifold role in the correct functioning of the human body, which is especially pronounced in the case of women. Prolonged exposure to oestrogen has been shown t ...
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