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19 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

ORTHOpedic randomized clinical trial with expanded bone marrow MSC and bioceramics versus autograft in long bone nonUNIONs (ORTHOUNION)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Current orthopaedic treatments permit spontaneous bone regeneration to unite and heal 90% bone injuries. Non-union associates pain and disability, often requiring biological enhancement. Regenerative medicine research suggests to the general public that alternative treatments based on advanced therapy medicinal products (ATMP) are already available. However, early clinical trials only explore its ...
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 13

 TERMINÉ 

Clinical trial of autologous adipose-derived mesenchymal stromal cells (ASC) in the treatment of mild to moderate osteoarthritis (ADIPOA2)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Osteoarthritis (OA) is an incurable disease that has evaded pharmacological interference, biologic therapy or surgical intervention to prevent disease progression. Currently, OA is designated the 11th highest contributor (of 291 diseases) of global disability. In the absence of effective treatment options, cellular therapies using mesenchymal stem/stromal cells (MSCs) have emerged as potential can ...
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 20

 TERMINÉ 

implementAtion anD OPeration of the gateway for healTh into BBMRI-ERIC (ADOPT BBMRI-ERIC)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2018,

"BBMRI-ERIC: the Biobanking and BioMolecular resources Research Infrastructure - European Research Infrastructure Consortium, aims to establish, operate and develop a Pan-European distributed research infrastructure in order to facilitate the access to biological resources as well as facilities and to support high quality biomolecular and biomedical research. The ADOPT BBMRI-ERIC proposal aims at ...
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 22

 TERMINÉ 

EURO EWING Consortium – International Clinical Trials to Improve Survival from Ewing Sarcoma (EEC)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Ewing Sarcomas (ES) are fatal, rare bone cancers particularly affecting young people. About 60% of patients achieve long term survival with current treatment but there has been no improvement in this proportion for 25 years. Treatment is unsuccessful because chemotherapy fails to prevent the development of, or to effectively treat established, metastases. In addition, of the 600 new cases of ES o ...
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 21

 TERMINÉ 

European Clinical trials in Rare Sarcomas within an integrated translational trial network (EUROSARC)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,

Sarcomas are rare malignant tumors, with an overall incidence of 6/105/year. Bone and soft tissue connective tissue tumours encompass more than 50 different rare histotypes and more than 150 different molecular subtypes. The incidence of individual rare sarcomas subtypes is often less than 0.5/105/year. Given sarcoma rarity as a group, but even more as individual entities, few prospective clinical ...
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 22

 TERMINÉ 

Cloud based Simulation platform for Manufacturing and Engineering (CloudSME)

Date du début: 1 juil. 2013, Date de fin: 31 mars 2016,

Simulation can significantly improve the competitive position of manufacturing and engineering companies by reducing their costs and resulting in more efficient development, production, procurement, logistics or financial processes. However, the take-up of simulation software by SMEs has until now been low due to high barriers of entry that include hardware prices, licensing costs and technical ex ...
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 29

 TERMINÉ 

Bioreactor-based, clinically oriented manufacturing of engineered tissues (BIO-COMET)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2015,

Despite significant achievements in the field of regenerative medicine and the enormous potential for engineered tissue products, significant hurdles have prevented cellular therapies from gaining wide-spread clinical adoption. Manufacturing related issues have been proposed as key challenges to be addressed for the translation of regenerative therapies to the clinic and the successful commerciali ...
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 9

 TERMINÉ 

Regenerating Bone defects using New biomedical Engineering approaches (REBORNE)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,

Bone is among the most frequently transplanted tissue with about 1 million procedures annually in Europe. The worldwide market of bone replacement materials is currently estimated at 5 billion € with a 10% annual growth. Despite their considerable disadvantages, including the risk of disease transfer and immunologic rejection, limited supply of bone, costs and complications, allografts and autogra ...
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 24

 TERMINÉ 

Virtual Physiological Human: Sharing for Healthcare - A Research Environment (VPH-Share)

Date du début: 1 mars 2011, Date de fin: 31 mai 2015,

VPH-Share will develop the organisational fabric (the infostructure) and integrate the optimised services to (1) expose and share data and knowledge, (2) jointly develop multiscale models for the composition of new VPH workflows, (3) facilitate collaborations within the VPH community. Four flagship workflows (from @neurIST, euHeart, VPHOP, Virolab) provide existing data, tools and models, engage w ...
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 20

 TERMINÉ 

COMPOSITE PHENOTYPIC TRIGGERS FOR BONE AND CARTILAGE REPAIR (OPHIS)

Date du début: 1 sept. 2010, Date de fin: 31 août 2014,

Osteoarthritis (OA) and osteoporosis (OP) are disabling, degenerative bone diseases with significant economic and societal impacts. The incidence of these conditions increases with age but in recent years the number of younger patients has increased, due mainly to factors related to modern life-styles. The efficiency of current pharmacologic and implant-based solutions are limited and often poorly ...
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 9

 TERMINÉ 

ADIPOSE DERIVED STROMAL CELLS FOR OSTEOARTHRITIS (ADIPOA)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2014,

Osteoarthritis (OA) is a degenerative joint disease for which no efficient therapy is available. The ADIPOA consortium has previously shown that intraarticular injections of stromal cells prevents OA in two different models, but the mechanisms of this chondroprotective effect remains unknown, and the activation of cartilage derived endogenous stem cells is suspected. The participants have experien ...
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 12

 TERMINÉ 

Bone motion Capture from video sequences (BOCAP)

Date du début: 31 janv. 2011, Date de fin: 30 janv. 2014,

The analysis of human movements, gathering quantitative information about the musculoskeletal system during the execution of a motor task, plays a fundamental role for the understanding of the system physiopathology. Current methods for capturing accurate 3D human motion require the attachment of devices like markers, fixtures or sensors, that may influence the execution of natural movements, requ ...
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 1

 TERMINÉ 

Digitally Integrated Scientific Data for Patients and Populations in User-Specific Simulations (DISCIPULUS)

Date du début: 1 oct. 2011, Date de fin: 30 juin 2013,

The DISCIPULUS SA aims at the grand challenge of the 'Digital VPH Patient'. It is an avatarof the models and individual data that allow health prediction and disease treatment whenthe 'Digital Me' of a citizen needs to avail itself of health services. In essence, it constitutes arevolutionary Clinical Prediction and Decision Support System. To realise this vision,DISCIPULUS develops a sound ICT re ...
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 5

 TERMINÉ 

VPHOP-SIMBIOS cooperation: Tools to develop the NeuroMusculoSkeletal Physiome (NMS Physiome)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2013,

The musculoskeletal apparatus is probably the organ system where the need for the integrative approach advocated by the Virtual Physiological Human (VPH) initiative is most pronounced. The neuromotor control involves the entire body, whereas the processes involved in muscle twitching, bones and muscle adaptation, musculoskeletal aging, and in most musculoskeletal diseases take place at the molecul ...
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 6

 TERMINÉ 

Virtual Physiological Human Network of Excellence (VPH NoE)

Date du début: 1 juin 2008, Date de fin: 31 mai 2013,

Description The Virtual Physiological Human Network of Excellence (VPH NoE), 2008-2013, served as a rallying point and source of best-practice information for the VPH community.  This role has now has been passed to the VPH Institute (http://www.vph-institute.org/).  The tools and educational/outreach materials developed by the VPH NoE – and ...
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 23

 TERMINÉ 

Enhanced patient safety by computational Modelling from clinically available X-rays to minimise the risk of overload and instability for optimised function and joint Longevity (MXL)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2012,

Osteorthritis (OA) is a disabling disease, affecting the joints of 40% or more of the population over 60, resulting in a socioeconomic burden of €7b. per year in Germany alone. Joint surgery attempts to address the various disease stages, to either minimize the risk of early degeneration of the native joint, or to replace a fully degenerated joint, with well over 1,000,000 surgeries performed annu ...
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 10

 TERMINÉ 

Osteoporotic Virtual Physiological Human (VPHOP)

Date du début: 1 sept. 2008, Date de fin: 31 oct. 2012,

Nearly four million osteoporotic bone fractures cost the European health system more than 30 billion Euro per year. This figure could double by 2050. After the first fracture, the chances of having another one increase by 86%. We need to prevent osteoporotic fractures. The first step is an accurate prediction of the patient-specific risk of fracture that considers not only the skeletal determin ...
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 21

 TERMINÉ 

Future and Emerging Technologies for the Virtual Physiological Human (VPH-FET)

Date du début: 1 sept. 2010, Date de fin: 30 sept. 2011,

The Virtual Physiological Human (VPH) is an initiative, supported by the European Commission, to create a computational framework to facilitate the understanding of the integrative function of molecules, cells, tissues, and organisms and, by this, to construct a multiscale in silico model of the human physiology.Specific Calls within Framework 7 have addressed the VPH, and the first set of VPH pro ...
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 2

 TERMINÉ 

Integrating outcome registers, retrieval analysis programs and preclinical validation methods into a synergistic post-marketing surveillance program for orthopedic devices (ORTHOWATCH)

Date du début: 6 juin 2008, Date de fin: 5 juin 2010,

There is increasing demand for technology to maintain the mobility of an aging worldwide population. Joint replacement is widely recognized as a successful orthopaedic surgical procedure for treating degenerative musculoskeletal conditions. However, joint replacement prostheses have limited longevity, especially in younger and more active people. Efforts to improve prosthesis longevity and perf ...
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 1