13 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Long-term, prospective study evaluating clinical and molecular biomarkers of epileptogenesis in a genetic model of epilepsy – tuberous sclerosis complex (EPISTOP)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,
Despite a great progress in the management of epilepsy, still one third of patients is refractory to available medications. The incidence of epilepsy is highest in infancy and 50% of children experience epilepsy-related comorbidities, such as developmental delay and autism. The development of epilepsy (epileptogenesis), extensively studied in animals, is barely studied in humans, as patients usual ...
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16
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TERMINÉ
Structural studies of Nucleotide Excision Repair complexes (NERCOMP)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,
"DNA damage caused by chemical and physical factors can lead to detrimental effects to the cell and must be corrected. One of the primary pathways to achieve this repair is nucleotide excision repair (NER). In NER, the DNA damage is first located, a stretch of bases harboring the lesion is removed, and the gap is filled by a DNA polymerase. The unique feature of NER is its ability to correct a wid ...
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1
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TERMINÉ
Better Experimental Screening and Treatment for Primary Ciliary Dyskinesia (BESTCILIA)
Date du début: 1 déc. 2012, Date de fin: 31 mai 2016,
Primary Ciliary Dyskinesia (PCD) is a rare genetically heterogeneous disorder which results from dysfunction of motile hair-like organelles (cilia) that results in severe, chronic airways disease. Due to other cilia-related disease mechanisms several other organ systems like the heart can be affected. The complexity of the disease phenotype, late diagnosis, as well as lack of evidence based manage ...
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12
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TERMINÉ
Fishing for Medicines and their targets using Zebrafish models of human diseases (FISHMED)
Date du début: 1 déc. 2012, Date de fin: 31 mai 2016,
The International Institute of Molecular and Cell Biology (IIMCB) was created with the support of UNESCO, Polish Academy of Sciences (PAN) and the Polish Government and started its activity in 1999. The Institute is a unique, innovative, based on the best world standards research centre, known for it’s scientific excellence. In 2010, IIMCB was ranked first among 36 biological institutions in Polan ...
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1
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TERMINÉ
Breaking the code of RNA sequence-structure-function relationships: New strategies and tools for modelling and engineering of RNA and RNA-protein complexes (RNA+P=123D)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,
Ribonucleic acid (RNA) is a large class of macromolecules that plays a key role in the communication of biological information between DNA and proteins. RNAs have been also shown to perform enzymatic catalysis. Recently, numerous new RNAs have been identified and shown to perform essential regulatory roles in cells.As with proteins, the function of RNA depends on its structure, which in turn is en ...
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1
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TERMINÉ
STRENGTHENING COOPERATION IN MOLECULAR BIOMEDICINE BETWEEN EU AND UKRAINE (COMBIOM)
Date du début: 1 déc. 2011, Date de fin: 31 mai 2015,
...nostics and therapy of oncological and neurodegenerative diseases. Widening and deepening the existing bilateral collaboration with two EU partners: Gustave Roussy Institute of Oncology, France, and International Institute of Molecular and Cell Biology, Poland, will provide creation of a new research consortium for enhanced involvement of the Ukrainian research center into the ERA (first objectiv ...
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3
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TERMINÉ
Effective Technology Transfer in Biotechnology (ETTBio)
Date du début: 31 déc. 2011, Date de fin: 30 déc. 2014,
ETTBio addresses the challenging issue of still unused economic potential of research institutes and universities as source for innovation and therefore efficient regional economic development. ETTBio has a sectoral focus on biotechnology for the following reasons: 1) Biotechnology is considered a key sector (and key enabling technology) in Europe for the 21st century, 2) it has very specific char ...
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10
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TERMINÉ
Transport and signalling in Polarized Cells (TRANSPOL)
Date du début: 1 déc. 2010, Date de fin: 30 nov. 2014,
.... A training in scientific and complementary skills including soft skills/4. An in-depth scientific training focused on a specific PhD topic/5. Doctoral examination under the auspices of external international examiners."
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11
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TERMINÉ
Engineered Sequence-Specific RNases: New Reagents for RNA biotechnology (ERNASES)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2013,
The basic idea to be taken to the proof of concept is creation of novel molecular biology tools, ie. enzymes acting on DNA/RNA hybrids and dsRNA that are able to cut the RNA strand(s) in a site specific manner. We have already created prototypic proteins of those two classes of ‘RNA restriction enzymes’ and performed initial steps towards commercialization of the project. We are applying for fundi ...
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1
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TERMINÉ
Exgenome Molecular Enzymes (EXGENOMES)
Date du début: 1 déc. 2011, Date de fin: 30 nov. 2013,
"The main objective of the EXGENOMES project is to develop new and improved thermostable enzymes for use, as reagents, in large-scale DNA synthesis and/or that can act on unnatural components such as in LNA (Locked Nucleic Acids). The target source for the new enzymes is a range of self-replicating mobile genetic elements (phages, plasmids and transposons) from thermophilic bacteria. Increased un ...
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8
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TERMINÉ
Structural Biology of Membrane Proteins (SBMPs)
Date du début: 1 sept. 2008, Date de fin: 31 août 2012,
...network combines 12 academic research groups and 3 industrial companies interested in collaborating with these groups and involved in drug discovery or scientific equipment for SBMP. These groups are internationally recognized for analysing the structure and dynamics of membrane proteins by a combination of experimental and theoretical approaches: in vivo and in vitro expressions systems, function ...
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12
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TERMINÉ
Proteins in Health and Disease (HEALTH-PROT)
Date du début: 1 avr. 2009, Date de fin: 31 mars 2012,
This project is targeted at continuation and expansion of activities initiated as the FP5 Centre of Excellence in Molecular Bio-Medicine (CEMBM). In the past as the Centre of Excellence we developed an advanced methodology of analysis of complex protein structures with the use of cell and molecular biology techniques, biochemical methods, crystallographic analysis and computer modelling. Our goal ...
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1
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TERMINÉ
GSK-3 in neuronal plasticity and neurodegeneration: basic mechanisms and pre-clinical assessment (NEURO.GSK3)
Date du début: 1 oct. 2008, Date de fin: 31 déc. 2011,
"Neuronal circuits in mammalian brain act predominantly via excitatory synapses on dendritic spines. Formation of new spines in adult brain constitutes the structural basis of neuronal plasticity. The underlying molecular mechanisms remain largely unknown but depend essentially on kinase-dependent signalling pathways. Final formation of synapses on spines depends on dynamic interactions of microtu ...
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