2 projets européens trouvés
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TERMINÉ
Genetic study of Common Hereditary Bowel Cancers in Hispania and the Americas (CHIBCHA)
Date du début: 1 juin 2009, Date de fin: 31 mai 2013,
"Colorectal cancer (CRC) is common in both sexes, has relatively poor outcome and has no major avoidable risk factor. Recent studies have shown that common inherited single nucleotide polymorphisms (SNPs) can increase cancer risk. We have shown CRC risk to be associated with SNPs on chromosomes 8q24.21, 15q14 and 8q21. These variants account for
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TERMINÉ
Development of sensitive methodologies for exploitation of early epigenetic marker diagnosis in major types of cancer (EpiDiaCan)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2012,
Cancer is one of the major causes of mortality. Epithelial cells become malignant after accumulating genetic mutations followed by morphological changes in the epithelium. DNA Alterations include stable genetic changes in oncogenes, tumor suppressor genes and reversible epigenetic changes. Different forms of epigenetic mechanisms have been shown to modify the expression of key genes during tumour ...
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