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 TERMINÉ 

PRINCIPLES OF AXIAL POLARITY-DRIVEN VASCULAR PATTERNING (AXIAL.EC)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

The formation of a functional patterned vascular network is essential for development, tissue growth and organ physiology. Several human vascular disorders arise from the mis-patterning of blood vessels, such as arteriovenous malformations, aneurysms and diabetic retinopathy. Although blood flow is recognised as a stimulus for vascular patterning, very little is known about the molecular mechanism ...
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 1

 TERMINÉ 

Quality Control and Maintenance of Synaptic Mitochondria (SynapticMitochondria)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

Mitochondria at the synapse have a pivotal role in neurotransmitter release, but almost nothing is known about synaptic mitochondria composition or specific functions. Synaptic mitochondria compared to mitochondria in other cells, need to cope with increased calcium load, more oxidative stress, and high demands of energy generation during synaptic activity. My hypothesis is that synaptic mitochond ...
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 1

 TERMINÉ 

Genetic and Small Molecule Modifiers of Lysosomal Function (LysoMod)

Date du début: 1 mars 2017, Date de fin: 28 févr. 2021,

LysoMod will innovate in the area of personalized medicine for disorders linked to lysosomal dysfunction. This will be achieved by implementing a collaborative staff-exchange program between highly complementary and multidisciplinary academic and non-academic partners with expertise in pharmacology, medicinal chemistry, cell biology, biochemistry, mouse and human genetics, transcriptomics, proteom ...
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 8

 TERMINÉ 

IL-7/IL-7R signaling networks in health and malignancy (IL7sigNETure)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Deregulation of signal transduction is a feature of tumor cells and signaling therapies are gaining importance in the growing arsenal against cancer. However, their full potential can only be achieved once we overcome the limited knowledge on how signaling networks are wired in cancer cells. Interleukin 7 (IL7) and its receptor (IL7R) are essential for normal T-cell development and function. Howev ...
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 1

 TERMINÉ 

Glia-derived factors in innate lymphoid cell sensing and intestinal defence (GliaInnateSensing)

Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,

The interplay between intestinal microbes and immune cells ensures vital functions of the organism. However, inadequate host-microbe relationships lead to inflammatory diseases that are major public health concerns.Innate lymphoid cells (ILC) are an emergent family of effectors abundantly present at mucosal sites. Group 3 ILC (ILC3) produce pro-inflammatory cytokines and regulate mucosal homeosta ...
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 1

 TERMINÉ 

MicroRNA determinants of the balance between effector and regulatory T cells in vivo (DevoTed_miR)

Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,

T lymphocytes display potent pro- or anti-inflammatory properties, which typically associate with distinct effector (Teff) versus regulatory (Treg) cell subsets. Based on published and our preliminary data showing a major impact of microRNAs on T cell differentiation and (auto)immune pathology, my proposal aims to dissect the miRNA networks that control the balance between Teff and Treg subsets i ...
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 1

 TERMINÉ 

Leverage research EXCELLence and INNOVation potential of Instituto de Medicina Molecular (IMM) through translational biomedical research in immunity and infection. (EXCELLtoINNOV)

Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,

EXCELLtoINNOV will provide IMM with the needed means to achieve excellence on a sustainable basis through the recruitment of an ERA Chair in translational biomedical research in immunity and infection. This goal will be strategically achieved by placing IMM in the forefront of Research, Development and Innovation (R&D+I) in immunity and infection, through the establishment of a translational biome ...
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 1

 TERMINÉ 

Conservative iron chelation as a disease-modifying strategy in Parkinson’s disease: a multicentric, parallel-group, placebo-controlled, randomized clinical trial of deferiprone (FAIR-PARK-II)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Parkinson’s disease (PD) is a major, chronic, non-communicable disease and the 2nd most frequent neurodegenerative disorder worldwide. Excess iron is primarily detected in the substantia nigra pars compacta, where dopaminergic neurons are exposed to high levels of oxidative stress produced by mitochondrial disorders and dopamine metabolism. Our previous preclinical, translational and pilot clinica ...
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 17

 TERMINÉ 

Innovative Management of Genetic Resources (IMAGE)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

This aim of IMAGE is to enhance the use of genetic collections and to upgrade animal gene bank management. IMAGE will better exploit DNA information and develop methodologies, biotechnologies, and bioinformatics for rationalising animal genetic resources. It will demonstrate the benefits brought by gene banks to the development of sustainable livestock systems by: enhancing the usefulness of genet ...
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 28

 TERMINÉ 

Repair of tissue and organ damage in refractory chronic graft versus host disease after hematopoietic stem cell transplantation by the infusion of purified allogeneic donor regulatory T lymphocytes (TREGeneration)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,

Our proposal encompasses parallel clinical trials addressing the feasibility and the effectiveness of donor-derived regulatory T cells (Treg) as a therapeutic agent in the treatment and prevention of tissue and organ damage resulting from graft versus host disease (GVHD) after hematopoietic stem cell transplantation (HSCT).We propose a collaborative clinical study in which Treg therapy for GHVD is ...
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 8

 TERMINÉ 

A training network for the chemical site-selective modification of proteins: Preparation of the next-generation of therapeutic chemically-defined protein conjugates (ProteinConjugates)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2019,

ProteinConjugates is an inter- and multi-disciplinary network for the education of talented young scientists who will learn how to rationally design and construct the next generation of chemically-defined and innovative protein drug-conjugates for the targeted treatment of serious conditions such as cancer or rheumatoid arthritis. A complementary interaction between academy and pharmaceutical indu ...
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 8

 TERMINÉ 

A training network for the rational design of the next generation of well-defined glycoconjugate vaccines (GLYCOVAX)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2019,

GLYCOVAX is a network for the education of promising young scientists who will learn how to rationally design a next generation of well-defined and innovative glycoconjugate vaccines to improve current preventive therapies and to tackle unmet medical needs. Glycoconjugate vaccines represent the key for success of vaccination in children. The covalent linkage to proteins renders carbohydrates able ...
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 12

 TERMINÉ 

European Network linking informatics and genomics of helper T cells (ENLIGHT-TEN)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2019,

ENLIGHT-TEN is a European Network Linking Informatics and Genomics of Helper T cells: our mission is to provide cross-disciplinary training in cellular immunology and big data analysis such that we train a new generation of researchers to fully exploit the power of emerging technological platforms. Our network of TEN beneficiaries combines T cell expertise with state-of-the-art technologies such a ...
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 11

 TERMINÉ 

Positioning the nucleus for cell migration and muscle fiber function (PhONICs)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,

The cell nucleus is positioned at specific places within the cytoplasm and this position is important for different cellular, developmental and physiological processes. Nuclear positioning depends on connections between nuclear envelope proteins and the cytoskeleton. In migrating cells, we found that the nucleus is positioned away from the front of the cell and this event is important for cell mig ...
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 1

 TERMINÉ 

Innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutical drug development, product market targeting, training , and communication. (INPACT)

Date du début: 1 févr. 2015, Date de fin: 31 janv. 2019,

INPACT aims at the pre-clinical development of innovative drugs and drug formulations against selected cancers (eg prostate cancer) and pathogenic bacteria (eg S. aureus). The INPACT consortium allies the expertise of both academic and industrial R&D partners that contribute with their own unique technologies to achieve new drugs that are only possible to develop in an integrative effort. Academic ...
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 8

 TERMINÉ 

Neurologic and Psychiatric Disorders: from synapses to networks (SynaNet)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,

...mote collaborative multidisciplinary and translational research by enhancing effective knowledge transfer, exchange of best research practices, and the mobility of early stage researchers between the Instituto de Medicina Molecular (IMM) at the University of Lisbon, the University of Eastern Finland, the University of Rome La Sapienza, and the Lancaster University at UK.IMM has widely recognized r ...
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 4

 TERMINÉ 

Unleash IMM’s research excellence in immunity and infection through twinning to infect Lisbon and Portugal with its increase in competitiveness and innovation (TwinnToInfect)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,

TwinnToInfect will provide IMM with the opportunity to integrate the European circle of research excellence institutions by cementing a sustainable science, technology and innovation network with two internationally-leading organisations in the immunity and infection area of research, the Institut Pasteur and the Francis Crick Institute. The strategy of TwinnToInfect, based on science- and innovat ...
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 3

 TERMINÉ 

Oxytocin and Dopamine Interplay in Humans – on the Biology of Social Cognition (BIOSOCIOCOG)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

"This project asks ‘Do oxytocin and dopamine systems interact in the human brain?’. It will encompass an innovative, inter- disciplinary method combining established techniques in neuropharmacology, neuroimaging and genetics. It will use a mentalizing (social dilemma) task where it is hypothesized that the trust-eliciting reward value of mutual cooperation is coded by both dopaminergic and oxytoci ...
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 1

 TERMINÉ 

Towards outstanding research and training in tumour biology at IMM (ReTuBi)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,

Cancer is a major societal health issue in Europe. In 2012, cancer accounted for around 1.3 million deaths and an estimated economic impact of around € 126 billion in the European Union (EU).The Instituto de Medicina Molecular (IMM) aims to fight this destructive disease by reinforcing its capacity for outstanding pre-clinical and translation research, and by creating a dynamic cluster of excellen ...
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 3

 TERMINÉ 

Advanced Postdoctoral Training Programme (MINDTHEGAP)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

...st research institutions lag to provide adequate training at the postdoctoral level.This project attempts to fill this gap with the creation of a novel Advanced Postdoctoral Training Programme at the Instituto de Medicina Molecular - a biomedical research institute in Lisbon. We will create a new programme featuring incoming transnational mobility and reintegration of fellows that combines the ext ...
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 1

 TERMINÉ 

BMX-targeted ligand-drug conjugates for prostate cancer therapy (LDC4PCaTher)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2018,

Standard of care strategies for the treatment of cancer still relies heavily on non-specific radiation and chemotherapy. These treatments are commonly associated with severe toxicities and in many cases only offer limited benefit for the patient. The targeted delivery of radionuclides, cytotoxic drugs and pro-inflammatory cytokines into malignant tissue, on the other hand, can markedly improve the ...
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 1

 TERMINÉ 

Drug Repurposing for Malaria Chemoprotection (REUSE4MALARIA)

Date du début: 1 déc. 2016, Date de fin: 31 mai 2018,

Malaria is a serious parasitic disease afflicting 198 million people in 2013, with an estimated death toll of approximately 600 000. Approximately half the world’s population is at risk of malaria. So far there is no cure/vaccine against malaria and current chemoprotective treatments have shortcomings, such as: 1) Limited Number of Drugs effective against malaria parasites; 2) Adverse Side Effects ...
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 1

 TERMINÉ 

Exploring pericyclic reactions for bioorthogonal imaging of biological processes with molecular precision (PerBioImage)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2018,

Bioorthogonal reactions have become essential tools for Chemical Biology and Drug Discovery. Despite recent advances in the development of bioorthogonal reactions, there still exists a need for reactions with improved kinetics and selectivities. Alkenes have been exploited in the context of site-specific protein modification and labelling, for example in cross-metathesis, photochemical 1,3-dipolar ...
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 1

 TERMINÉ 

European Clinical Research Infrastructures Network - Integrating Activity (ECRIN-IA)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,

ECRIN is a distributed ESFRI-roadmap pan-European infrastructure designed to support multinational clinical research, making Europe a single area for clinical studies, taking advantage of its population size to access patients. Servicing multinational trials started during its preparatory phase, and it now applies for an ERIC status by 2011. The ERIC budget will be restricted to core activities re ...
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 48

 TERMINÉ 

Parasite glycobiology and anti-parasitic strategies (GLYCOPAR)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2017,

"Protozoan parasites and helminths are the cause of some of the most devastating diseases worldwide and a major effort is needed to be able to control or eliminate these diseases. Glycoconjugates are abundant and ubiquitous on the surface of many parasites and they are frequently involved in their survival strategies by forming a protective barrier against host defences. A common feature of the pa ...
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 13

 TERMINÉ 

Nutrient sensing by parasites (ParasiteNutriSensing)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,

As any other obligate parasite, Plasmodium depends on its hosts and on the nutrients they provide to survive and complete its life cycle. Surprisingly, nothing is know about Plasmodium’s capacity to sense nutrients or its host’s nutritional status and thereby reprogram its metabolism. Our preliminary data provides unequivocal evidence that Plasmodium has the ability to sense the host low-nutrient ...
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 1

 TERMINÉ 

Dengue research Framework for Resisting Epidemics in Europe (DENFREE)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

"WHO estimates that one of the main consequences of global warming will be an increased burden of vector-borne diseases. Among these, dengue appears to be particularly problematic, with tens of millions of cases of dengue fever estimated to occur annually, including up to 500,000 cases of the life-threatening dengue hemorrhagic fever/dengue shock syndrome. In recent years, the global burden of den ...
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 15

 TERMINÉ 

The role of non coding RNA in human health and disease (RNA_REGULOMICS)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

"RNA molecules have been already proven to be a key target for disease therapy as well as a tool for the development of new drugs. Since the discovery of small non coding RNA (ncRNA) and all the associated phenomena like RNA interference, the possibility of using RNA-based drugs has become a subject of great interest in the pharmaceutical and clinical fields. ncRNA is at the core of many cellular ...
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 3

 TERMINÉ 

Stromal Cell- Immune Cell Interactions in Health and Disease (STROMA)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

STROMA is an Initial Training Network promoting the study of stromal cell – immune system interactions during stroma development and function in health and disease. In STROMA we have bought together world leading experts from academia and industry in Europe to address the key scientific questions in this emerging field. STROMA will promote the training of three Experienced Researchers (ER) and s ...
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 12

 TERMINÉ 

"""RNPnet"" - RNP structure, function and mechanism of action" (RNPNET)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

RNA molecules are at the heart of life. It is now commonly admitted that nearly all the human genome is transcribed, and a wealth of new coding and non-coding RNAs have been discovered. Importantly, modern RNAs are never naked, but always exist in complex with proteins to form RNPs (Ribonucleoproteins). In the case of non-coding RNAs, these proteins are usually stably associated with the RNA and h ...
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 15

 TERMINÉ 

Differentiation of pro-inflammatory T cell subsets in vivo (T_CELL(S)_DIFFER)

Date du début: 1 déc. 2010, Date de fin: 30 juin 2015,

Our understanding of T cell differentiation impacts on vaccine development and on the treatment of (auto) immune disorders. T cells are key players in inflammation, a crucial component of the immune response to pathogens that causes severe damage to the host when uncontrolled. The cytokines Interferon-(IFN-) and Interleukin-17 (IL-17) are critical mediators of the proinflammatory activity of T ...
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 1

 TERMINÉ 

Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR) (EVIMalaR)

Date du début: 1 oct. 2009, Date de fin: 31 mars 2015,

This is a proposal from 55 partners from 36 institutes to form a NoE that will seek to integrate European malaria research that is directed towards a better understanding of the basic biology of the parasite, its vector and of the biology of the interactions between the parasite and both its mammalian host and vectors. All the member institutes and researchers have demonstrated both their excellen ...
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 40

 TERMINÉ 

A novel solution to efficient Haematopoietic Stem Cell regeneration (STEMCELL2MAX)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2015,

There is an urgent need for improved expansion protocols for haematopoietic stem cells (HSCs). Many studies have tried to stimulate HSC expansion by experimenting with cytokine cocktails in cell culture media. Although these combinations of growth factors are able to increase the amount of HSCs, this happens at the cost of cell maturation: many of the cells in the final culture have lost their 'st ...
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 1

 TERMINÉ 

Epithelial Resealing (RESEAL)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2014,

Epithelia have the essential role of acting as a barrier that protects living organisms and its organs from the surrounding milieu. Therefore, it is crucial for epithelial tissues to have robust ways of maintaining its integrity despite the frequent damage caused by normal cell turnover, inflammation and injury. All epithelia have some capacity to repair themselves, however, the wound-healing proc ...
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 2

 TERMINÉ 

SENSE-PARK: Supporting and Empowering Parkinson patients in their home environment using a Novel SEnsory information system that monitors daily-life-relevant parameters of PARKinson disease and their (SENSE-PARK)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2014,

Parkinson's disease (PD) is the second most common neurodegenerative disease, and prevalence increases with age. This leads, in an aging society, to increasing personal, social and economic burden. To date, basically only symptomatic treatment is available, which application almost always leads to the feeling of dependence and lose of self-control in (a) person(s) with PD (PwP's). A further shortc ...
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 7

 TERMINÉ 

Survey of tissue-specific alternative splicing in vertebrates by high-throughput sequencing: finding the elements of an evolutionary ‘splicing predictor’ (EVOALTSPLICE)

Date du début: 1 juin 2011, Date de fin: 31 mai 2014,

Splicing is a crucial aspect of gene regulation and this step in the processing of pre-mRNA to mature mRNA must occur with extreme precision to ensure that the correct message is translated by the ribosome. The coding potential and functional versatility of genes is dramatically increased by alternative splicing pathways that generate different protein isoforms, very often in a developmental stage ...
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 1

 TERMINÉ 

Chromatin and antigenic variation: The role of histone H1 in gene regulation in African trypanosomes (HistoneH1Tryp)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2014,

Trypanosoma brucei is a unicellular parasite that causes African sleeping sickness, a fatal disease in humans. There is no vaccine and drugs are very scarce and toxic. T. brucei evades the host immune system by periodically changing its dense, uniform coat of variant surface glycoproteins (VSGs), a mechanism knows as antigenic variation. There are hundreds of VSG genes in the genome, but only one ...
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 1

 TERMINÉ 

Research capacity for the implementation of genetic control of mosquitoes (INFRAVEC)

Date du début: 1 sept. 2009, Date de fin: 28 févr. 2014,

Mosquitoes transmit a variety of infectious diseases that cause a tremendous burden to public health. Due to climate changes and to the increase in international trade and tourism the threats posed by mosquitoes are increasingly affecting large parts of Europe, causing understandable concerns among the populations of many Member States. Control methods, mainly based on insecticide usage, are strug ...
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 31

 TERMINÉ 

"Membrane-active peptides across disciplines and continents: An integrated approach to find new strategies to fight bacteria, dengue virus and neurodegeneration." (MEMPEPACROSS)

Date du début: 1 févr. 2010, Date de fin: 31 janv. 2014,

"Peptide-lipid interactions are critical in several biomedical matters that seem uncorrelated at a first glance. MEMPEPACROSS deals with some of these: 1) Lipid membrane-interactions are the key for the understanding of dengue virus assembly and can constitute a target for its inhibition. Viral hemorrhagic fever caused by dengue virus is a serious threat to Europe, as its vector is already present ...
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 3

 TERMINÉ 

Role of the proto-oncogene Ret during lymphocyte development and function (RETIMMUNEFUNCTION)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2013,

There is growing evidence that molecules classically allocated to nervous system function, such as the neurotrophic factors, are produced by lymphocytes and can also regulate their function. The neurotrophic family includes the GDNF ligands (GFLs), which signal through the RET tyrosine kinase receptor. In humans, mutations of the proto-oncogene Ret have been linked to different diseases, such as c ...
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 1