5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Open Collaborative Model for Tuberculosis Lead Optimisation (ORCHID)
Date du début: 1 janv. 2011, Date de fin: 30 juin 2015,
"Early stage Drug Discovery efforts over the last 5 years have resulted in the identification of a number of promising lead compounds in the fight against TB. These leads need to be further progressed and optimised into candidates for pre-clinical development through the Drug Development progression cascade.Three compound families are of particular interest: 1) InhA Inhibitors, 2) New potent whole ...
Voir le projet
14
Participants partenaires
TERMINÉ
Small-molecule Inhibitor Leads Versus emerging and neglected RNA viruses (SILVER)
Date du début: 1 oct. 2010, Date de fin: 31 mars 2015,
RNA virus infections kill millions of humans annually, largely due to the lack of suitable vaccines and drugs to control them. This problem is addressed in this FP7 call and in response a consortium of Europe’s and Asia’s leading molecular virologists, structural biologists, medicinal chemists and bioinformaticians has been brought together to generate a state-of-the-art drug discovery and design ...
Voir le projet
25
Participants partenaires
TERMINÉ
Discovery and preclinical development of new generation tuberculosis vaccines (NEWTBVAC)
Date du début: 1 janv. 2010, Date de fin: 28 févr. 2014,
"With 14.4 million prevalent cases and 1.7 million deaths tuberculosis (TB) remains one of the most serious infectious diseases to date. An estimated 2 billion people are believed to be infected with Mycobacterium tuberculosis and at risk of developing disease. Multi- and extensively drug resistant strains are increasingly appearing in many parts of the world, including Europe. While with current ...
Voir le projet
39
Participants partenaires
TERMINÉ
Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LEISHDRUG)
Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,
"Visceral leishmaniasis is caused by the protozoan parasites Leishmania donovani and Leishmania infantum and is a potentially fatal disease in endemic areas around the world. During the infectious cycle, Leishmania alternate between the insect promastigote stage and the vertebrate aflagellate amastigote stage that proliferates inside infected host macrophages provoking the pathology of the disease ...
Voir le projet
13
Participants partenaires
TERMINÉ
Mycobacterium tuberculosis W-Beijing genetic diversity and differential virulence and host immune responses (TB-VIR)
Date du début: 1 avr. 2008, Date de fin: 31 mars 2011,
"Improvements in TB control require the development of new tools for rapid and accurate diagnosis and intervention. This development is likely to benefit from more detailed knowledge of microbe-host relationships during infection. Following M. tuberculosis infection, only 5-10% of immunocompetent individuals develop TB. It is increasingly thought that the virulence of the infecting strain, togethe ...
Voir le projet