Plus de 40 projets européens trouvés
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TERMINÉ
Common mechanisms of host membrane trafficking subversion by intracellular pathogens to rupture bacterial containing vacuoles (EndoSubvert)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,
A common strategy of bacterial pathogens is active or passive uptake into host cells. There, they can localize within a bacterial containing vacuole (BCV) or access the host cytoplasm through BCV rupture. Hence, intracellular pathogens are often classified as vacuole-bound or cytoplasmic. Recently, this definition has been challenged by the discovery that many vacuole-bound pathogens, including My ...
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1
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TERMINÉ
Development, maintenance and functions of Resident Macrophages. (ResidentMacroPhage)
Date du début: 1 déc. 2016, Date de fin: 30 nov. 2021,
Macrophages are professional phagocytic cells that orchestrate homeostatic and innate immune functions, via the scavenging of cells, debris, and pathogens, and the production of cytokines, both concurring to tissue homeostasis and repair. This project aims to investigate in vivo the development and functions of macrophages, which have considerable phenotypic and functional diversity depending on t ...
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1
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TERMINÉ
Microbial invasion and dissemination within the host, mechanisms and effects (INVADIS)
Date du début: 1 nov. 2016, Date de fin: 31 oct. 2021,
An infection is defined by the deleterious consequences of the interactions between a pathogen and a host. Thus, studying the biology of infection reveals critical properties of hosts and pathogens, and is a way forward to address basic biological questions and improve health.We study listeriosis, a systemic infection caused by Listeria monocytogenes (Lm). Lm is a human foodborne pathogen that cro ...
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1
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TERMINÉ
New and mature neurons in adult circuits: telling memories apart (NEWRON)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
How does the brain distinguish between memories that closely resemble each other? The hippocampal dentate gyrus has been suggested to serve this purpose by generating non-overlapping memory representations in a process termed “pattern separation”. Intriguingly, during adult life, the dentate gyrus is constantly supplied with new neurons, providing new circuit elements that can incorporate into the ...
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1
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TERMINÉ
Population genomics of co-evolution between non-retroviral RNA viruses and their hosts (NIRV_HOST_INT)
Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,
Recent discoveries clearly show that non-retroviral RNA viruses, despite not coding for reverse transcriptase and integrase, can transfer genetic material to their hosts, similarly to DNA viruses and retroviruses. The distribution of non-retroviral integrated RNA viruses (NIRVs) in host populations, mechanisms of NIRVs formation and effects on hosts are unclear. The main objective of this proposal ...
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2
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TERMINÉ
Regulation of cell size and shape in bacteria (RCSB)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,
Proper cell size and shape are important for many biological functions, such as metabolism, signaling, motility, and development. This proposal addresses the fundamental question of how bacteria control their morphology and their cell volume with high precision, using the rod-like bacterium Escherichia coli as a primary model system. Bacterial cell shape is physically determined during growth by t ...
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1
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TERMINÉ
Study of the interplay between CRISPR interference and DNA repair pathways towards the development of novel CRISPR tools (CRISPAIR)
Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,
CRISPR-Cas loci are the adaptive immune system of archaea and bacteria. They can capture pieces of invading DNA and use this information to degrade target DNA through the action of RNA-guided nucleases. The consequences of DNA cleavage by Cas nucleases, i.e. how breaks are processed and whether they can be repaired, remains to be investigated. A better understanding of the interplay between DNA r ...
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1
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TERMINÉ
Mechanisms of epigenetic inheritance by short RNAs (RNAEPIGEN)
Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,
Epigenetic mechanisms are considered to be central to the development of multicellular organisms made of different cell types, all having identical genomes. Similarly, they may explain how genetically identical organisms are capable of adapting to distinct environmental conditions. Yet, the molecular mechanisms regulating how epigenetic traits can be inherited during cell division or across genera ...
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1
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TERMINÉ
SustainAble Farming for Effective Aquaculture (SAFE-Aqua)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
... SAFE-Aqua will synergize the cutting-edge technology platforms, multidisciplinary and complementary expertise, as well as infrastructure from networks of the partnership among the leading research institutes in France, UK and Thailand and a synthetic biology company in Spain. The outcomes of SAFE-Aqua will undoubtedly help improve competitiveness of EU aquaculture industry whose growth has been r ...
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3
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TERMINÉ
Towards enduring mouse resources and services advancing research into human health and disease (INFRAFRONTIER2020)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st ...
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33
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TERMINÉ
European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates (EHVA)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur ...
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43
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TERMINÉ
Training European Experts in Multilevel Bioimaging, Analysis and Modelling of Vertebrate Development and Disease (ImageInLife)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
This proposal sprang from European scientists in both academia and industry who identified a common challenge: setting up a training frame to educate the next generation of imagers in complex biological systems (healthy & pathological), so they are able to master all major aspects of this competitive field and bring important innovations to universities and companies.The long-term goal of any init ...
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11
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TERMINÉ
Comorbidity and Synapse Biology in Clinically Overlapping Psychiatric Disorders (COSYN)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
COSYN integrates outstanding European academic and three large Pharma to exploit genomic findings for intellectual disability (ID), autism, and schizophrenia. We capitalise on comorbidity, from clinic to cells and synapses, and have access to large existing samples. We focus on rare genetic variants of strong effect in patients with clinical comorbidity. Our aims are: (1) Understand comorbidity by ...
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14
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TERMINÉ
Synthetic bacterial lipid rafts to optimize industrial bioprocesses (Rafts4Biotech)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
Genetic tractability of bacterial cells allows generating synthetic microbial chassis platforms (SMCPs) with remarkable biotechnological applications but their functionality currently faces important off-genome limitations due to deficient protein-protein interactions, unfavorable protein stoichiometry or generation of toxic intermediates that ultimately compromise the industrial production proces ...
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13
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TERMINÉ
Comprehensive characterization and effective combinatorial targeting of high-grade serous ovarian cancer via single-cell analysis (HERCULES)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
The goal of this multidisciplinary project is to comprehensively characterise high-grade serous ovarian cancer (HGS-OvCa) at single-cell level, identify the best combination of drug combination to kill HGS-OvCa populations and commercialise a predictive biomarker kit for finding the right therapeutic regimen to the right patient.This project takes an advantage on prospectively and longitudinally ...
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9
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TERMINÉ
Common mechanisms and pathways in Stroke and Alzheimer's disease. (CoSTREAM)
Date du début: 1 déc. 2015, Date de fin: 30 nov. 2020,
Common mechanisms and pathways in Stroke and Alzheimer's disease.It has long been recognized that stroke and (Alzheimer’s Disease) AD often co-occur and have an overlapping pathogenesis. As such, these two diseases are not considered fellow travelers, but rather partners in crime. This multidisciplinary consortium includes epidemiologists, geneticists, radiologists, neurologists with a longstandin ...
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11
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TERMINÉ
Perivascular cells at the crossroads of inflammation, regeneration and fibrosis (PERIF)
Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,
The survival of organisms requires the ability to repair tissues upon injury, as well as, after birth, to fight foreign invaders that may have contaminated the wound. This last function is mediated by a complex host response involving immune cells, blood vessels and inflammatory mediators that collectively intend to neutralize the harmful agent and eliminate damaged/necrotic tissue. Initially bene ...
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1
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TERMINÉ
Institut Pasteur International Docotal Program (PASTEURDOC)
Date du début: 1 oct. 2015, Date de fin: 30 sept. 2020,
PASTEURDOC is an advanced educational and research program, hosted by the Institut Pasteur in Paris. Its goal is to train junior investigators possessing medical and/or scientific educational backgrounds to become future leaders in academic education and research institutions, international organizations, private companies, or administration. PASTEURDOC is intended to co-fund and advance the alrea ...
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1
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TERMINÉ
Unraveling Principles of PDZ-mediated Cell Signaling (PDZnet)
Date du début: 1 sept. 2016, Date de fin: 31 août 2020,
...tific and transferable skills, the students will receive an interdisciplinary, intersectoral and innovative doctoral training from experienced industrial and academic leaders in well-reputed European Institutions.
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10
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TERMINÉ
Virus-X: Viral Metagenomics for Innovation Value (Virus-X)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2020,
Biological sequence diversity in nowhere as apparent as in the vast sequence space of viral genomes. The Virus-X project will specifically explore the outer realms of this diversity by targeting the virosphere of selected microbial ecosystems and investigate the encoded functional variety of viral gene products. The project is driven by the expected large innovation value and unique properties of ...
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15
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TERMINÉ
Zoonotic Anticipation and Preparedness Initiative (ZAPI)
Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,
...niting the human medical and veterinary fields, dedicated to swiftly controlling upon emergence pathogens both at the source and in the human population. In this project, human and veterinary medical institutions, governmental regulatory agencies, expert academic groups and industrial partners, building on existing EU-funded consortia and initiatives, collaborate in establishing a universal platfo ...
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21
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TERMINÉ
Accelerated Early staGe drug diScovery (AEGIS)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,
...ovation environment for innovative drug development in Europe. It is supported by several additional partners and stakeholders in the field. Integrated training of the fellows takes place at the host institute and by secondments, research schools and individual training within the AEGIS network. The scientific training includes complementary skills, management, intellectual property rights, fund r ...
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11
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TERMINÉ
Dynamics of the RNAi-mediated antiviral immunity (RNAiMMUNITY)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,
RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that is induced by double-stranded RNA (dsRNA). Double-stranded RNA is commonly generated during viral replication and is considered to be a molecular pattern associated with viral infection. Our previous work demonstrated that viral infections in the fruit fly Drosophila melanogaster are countered by an antiviral R ...
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1
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TERMINÉ
Principles of Polarity – Integrating genetic, biophysical and computational approaches to understand cell and tissue polarity (PolarNet)
Date du début: 1 oct. 2015, Date de fin: 30 sept. 2019,
The ability of cells to polarize underlies the most basic biological functions such as motility and response to external challenges, but also the formation and maintenance of tissues in a multicellular organism. The importance of cell polarity is underscored by the fact that cell polarity is essential for animal development and is perturbed in disease states such as cancer. Understanding cell pola ...
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9
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TERMINÉ
ELIXIR-EXCELERATE: Fast-track ELIXIR implementation and drive early user exploitation across the life-sciences. (ELIXIR-EXCELERATE)
Date du début: 1 sept. 2015, Date de fin: 31 août 2019,
...LIXIR - the European life science Infrastructure for Biological Information - is a distributed organisation comprising national bioinformatics research infrastructures and the European Bioinformatics Institute (EMBL-EBI). This coordinated infrastructure includes data standards, exchange, interoperability, storage, security and training.Recognising the importance of a data foundation for European l ...
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47
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TERMINÉ
Labeling Flavivirus capsid protein to unravel its dynamics during infection and egress by correlative super-resolution fluorescence and cryo-electron microscopy (FLAVIC DYNAMICS)
Date du début: 1 sept. 2017, Date de fin: 31 août 2019,
Vector-borne diseases are major worldwide threats. Specifically, mosquito-borne diseases from the flavivirus genus such as West Nile and dengue viruses are raising major concerns on human health. There are few or no treatment/vaccine strategies to fight these viruses and the relatively poor knowledge of their life cycle (entry and egress) contributes to the deficit in treatment possibilities. A de ...
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1
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TERMINÉ
Characterization of zebrafish innate lymphoid cells and IL-22 (ZF-ILC)
Date du début: 1 sept. 2017, Date de fin: 31 août 2019,
The immune system can be subdivided into two main arms: the innate and the adaptive. Recently, it was identified a new family of cells belonging to the innate system but that phenotypically and functionally resemble the specific subtypes of adaptive T lymphocytes. In mice and in humans, these innate lymphoid cells (ILCs) play critical roles in host defense, in shaping the microbiota and in tissue ...
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1
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TERMINÉ
European Marine Biological Research Infrastructure Cluster to promote the Blue Bioeconomy (EMBRIC)
Date du début: 1 juin 2015, Date de fin: 31 mai 2019,
Marine (blue) biotechnology is the key to unlocking the huge economic potential of the unique biodiversity of marine organisms. This potential remains largely underexploited due to lack of connectivity between research services, practical and cultural difficulties in connecting science with industry, and high fragmentation of regional research, development and innovation (RDI) policies. To overcom ...
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27
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TERMINÉ
European Virus Archive goes global (EVAg)
Date du début: 1 avr. 2015, Date de fin: 31 mars 2019,
The overall objective will be to create and mobilise an International network of high calibre centres around a strong European group of institutes selected for their appropriate expertises, to collect, amplify, characterise, standardise, authenticate, distribute and track, mammalian and other exotic viruses. The network of EVAg laboratories including 25 institutions represents an extensive range o ...
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27
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TERMINÉ
Imaging and Regulation of the Cellular Dynamics Driving the Vertebrate Limb Formation (LimbCellDynamics)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,
Limb defects, which are amongst the most frequent congenital malformations in humans, are the result of deviation in normal developmental program deployment affecting limb specification, initiation or patterning. In most cases the mechanisms underlying limb abnormalities are, at the best, poorly defined. This is in part due because despite considerable advances in our understanding of normal limb ...
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1
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TERMINÉ
Decrypting signals in the crypt (DECRYPT)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,
Pathogens and symbionts: War and Peace at mucosal surface in intestinal crypts.In the proposed program called DECRYPT, I wish to strengthen novel orientations of our laboratory aimed at decrypting the dialogue between the microbiota and the host, while keeping a balance with the study of pathogens, both being analyzed at their interface with the gut mucosa to further our knowledge of the homeostat ...
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1
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TERMINÉ
Cell-Cell fusion in fertilization and developmental biology: a structural biology approach (Celcelfus)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
My group has made seminal contributions in the past toward understanding the mechanism of membrane fusion used by enveloped viruses to infect a cell. This aim of this ERC grant proposal is to achieve similar breakthroughs in understanding fusion between cells, both during fertilization and organogenesis. This proposal is based in recent important results not yet published.We have determined the cr ...
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1
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TERMINÉ
Co-evolution of viruses, plasmids and cells in Archaea: pattern and process (EVOMOBIL)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
Interactions between cells and mobile elements such as viruses and plasmids (the mobilome) have played a major role in life evolution. However, up to now, evolutionary studies have mainly focused on cellular genomes (building species trees). My project is to reconstruct the history of interaction between cells, plasmids and viruses (PVs) at the domain level to answer questions such as: to which ex ...
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2
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TERMINÉ
Platform foR European Preparedness Against (Re-)emerging Epidemics (PREPARE)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
Far from receding, the threats posed by infections with epidemic potential grow ever greater. Although Europe has amongst the best healthcare systems in the world, and also the world’s supreme researchers in this field, we lack co-ordination and linkage between networks that is required to respond fast to new threats. This consortium of consortia will streamline our response, using primary and sec ...
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27
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TERMINÉ
A portable MicroNanoBioSystem and Instrument for ultra-fast analysis of pathogens in food: Innovation from LOVE-FOOD lab prototype to a pre-commercial instrument (LoveFood2Market)
Date du début: 1 févr. 2016, Date de fin: 31 janv. 2019,
The development of new methodologies advancing the state of the art in foodborne pathogen detection is a challenge for scientists and technologists as well as food industry and consumers. This project aims to meet the challenge by providing a reliable and versatile solution thanks to the convergence of micro-nano-bio systems. The work capitalizes on several innovative concepts which have already b ...
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8
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TERMINÉ
UNDERSTANDING THE CLOSTRIDIUM SPORE, A PREREQUISTE FOR DISEASE INTERVENTIONS AND EXPLOITATION (CLOSPORE)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,
Bacterial endospores are the most resistant life-forms on earth and the most important single feature of the genus Clostridium. Thus, whilst the pathogenesis of its notorious pathogens (C. botulinum, C. perfringens and C. difficile) is ascribed to the devastating toxins produced (neurotoxins, endotoxins and cytotoxins), it is their capacity to produce spores that lies at the heart of the diseases ...
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8
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TERMINÉ
TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development (TBVAC2020)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,
The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Express ...
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49
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TERMINÉ
Human Antibody Responses to Viruses (HumAntiViruses)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,
In addition to polyreactive “natural antibodies” that act as the first line of defense against invading pathogens, “humoral memory” is composed of high affinity antibodies that mediate long-lived immunity against infectious agents, e.g., providing protection against re-infection. The molecular dissection of anti-pathogen B-cell responses using modern technologies to generate specific monoclonal an ...
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1
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TERMINÉ
Unleash IMM’s research excellence in immunity and infection through twinning to infect Lisbon and Portugal with its increase in competitiveness and innovation (TwinnToInfect)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,
TwinnToInfect will provide IMM with the opportunity to integrate the European circle of research excellence institutions by cementing a sustainable science, technology and innovation network with two internationally-leading organisations in the immunity and infection area of research, the Institut Pasteur and the Francis Crick Institute. The strategy of TwinnToInfect, based on science- and innovat ...
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3
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TERMINÉ
Accelerated Development of Vaccine benefit-risk Collaboration in Europe (ADVANCE)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
Aim: The ADVANCE vision is focused on Timely and Best Evidence on Vaccine Effects. Our mission is to establish a best practice framework to rapidly provide robust data on vaccine benefits and risks to support accelerated decision-making.Approach: To achieve this vision through a public-private partnership, ADVANCE partners 1. establish common grounds and rules for collaboration between public and ...
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