10 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Beta Cell Generation by Stem Cell-Derived Implants in Diabetes (BetaCellTherapy)
Date du début: 1 déc. 2015, Date de fin: 31 août 2020,
Despite improved treatment, diabetes remains a chronic disease with major health risks and heavy burden on patients and society. Serious forms are caused by depletion in pancreatic beta cells and associated loss in insulin’s homeostatic control throughout life. Their cure requires restoration of a metabolically adequate beta cell mass. Implants of beta cell grafts prepared from human pancreases ha ...
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8
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TERMINÉ
Aetionomy – Organising Mechanistic Knowledge about Neurodegenerative Diseases for the Improvement of Drug Development and Therapy (AETIONOMY)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,
IMI’s Call 8 is geared to develop knowledge frameworks for ‘druggable mechanisms’ for two domains of pathophysiology. In response to this call, we propose (I) the development of a generic AETIONOMY pipeline to capture and infer over mechanistic knowledge of pathophysiology, and (II) the focused application of this pipeline to derive clinically significant mechanistic taxonomies of neurodegenerativ ...
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20
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TERMINÉ
"Epilepsies of the temporal lobe: emergence, basal state and paroxysmal transitions" (HEP)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
"This proposal focuses on a human disease: epilepsy of the temporal lobe. This syndrome has a relatively stereotyped history. Focal seizures emerge, with a delay of several years in the human, after an initial insult that results in neuronal death. We will use physiology, imaging, anatomy and transcriptomic techniques to ask how an epileptic brain emerges, to define different neuronal cell types ...
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1
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TERMINÉ
Human Brain Project Specific Grant Agreement 1 (HBP SGA1)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,
Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses I ...
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126
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TERMINÉ
Dynamic sensory-motor integration in spinal circuits (Optoloco)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,
Although locomotion may seem effortless, it relies on spinal circuits producing extraordinarily complex patterns of muscle contractions. Graded movements occur over a wide range of amplitudes and frequencies, instantaneously adapting to changes in the environmental or inner state. Locomotion relies on oscillations generated by genetically determined circuits within the spine. Sensory information f ...
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1
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TERMINÉ
The Human Brain Project (HBP)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,
...imulation, High Performance Computing, Medical Informatics, Neuromorphic Computing and Neurorobotics, and create a user community of research groups from within and outside the HBP, set up a European Institute for Theoretical Neuroscience, complete a set of pilot projects providing a first demonstration of the scientific value of the platforms and the Institute, develop the scientific and technolo ...
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116
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TERMINÉ
Improving the lives of Parkinson’s Disease patients while reducing side-effects through tailored deep brain stimulation (IMPACT)
Date du début: 1 sept. 2012, Date de fin: 31 août 2016,
The IMPACT project is about improving the lives of brain diseased patients through a novel approach that leaps beyond currently available Deep Brain Stimulation (DBS) devices and procedures. The initial project focus is on Parkinson’s Disease (PD), but further brain-disease indications will be included in the later phase of the project. The personalized approach that IMPACT brings is essential in ...
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10
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TERMINÉ
Unraveling the circuits of locomotion with opto-genetic manipulation of neuronal activity in awake behaving animals (Opto-Loco)
Date du début: 1 nov. 2011, Date de fin: 2 mai 2016,
Locomotion relies on neural networks called central pattern generators (CPGs) that generate periodic motor commands for rhythmic movements. The manipulation of electrical activity and cell signaling in specific neuron type using light gated receptors enables us today to dissect the specific neuronal circuits forming the CPGs, and understand the dynamic role of sensory inputs in awake behaving anim ...
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1
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TERMINÉ
Developing novel models of Amyotrophic Lateral Sclerosis using motor neuron cultures and zebrafish (Novel ALS Models)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,
In 2008, I led a team that identified mutations in the TAR DNA binding protein (TARDBP) gene that encodes TDP-43 in ALS patients, which is enriched in inclusion bodies present in motor neurons from ALS patients. Also, mutations in the fused in sarcoma (FUS) gene were identified in ALS patients, with FUS involved in similar molecular mechanisms as TDP-43. This project aims to elucidate mechanisms i ...
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1
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TERMINÉ
Self-Modulating Neurons in the Cerebral Cortex: From Molecular Mechanisms to Cortical Network Activities (CORTEXSELFCONTROL)
Date du début: 1 oct. 2008, Date de fin: 31 mars 2014,
"In the mammalian brain, the neocortex is the site where sensory information is integrated into complex cognitive functions. This is accomplished by the activity of both principal glutamatergic neurons and locally-projecting inhibitory GABAergic interneurons, interconnected in complex networks. Inhibitory neurons play several key roles in neocortical function. For example, they shape sensory recep ...
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