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 TERMINÉ 

Personalised Risk assessment in febrile illness to Optimise Real-life Management across the European Union (PERFORM)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

The management of febrile patients is one of the most common and important problems facing healthcare providers. Distinction between bacterial infections and trivial viral infection on clinical grounds is unreliable, and as a result innumerable patients worldwide undergo hospitalization, invasive investigation and are treated with antibiotics for presumed bacterial infection when, in fact, they ar ...
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 19

 TERMINÉ 

European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates (EHVA)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur ...
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 43

 TERMINÉ 

European AIDS Vaccine Initiative 2020 (EAVI2020)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,

HIV-1 is responsible for a global pandemic of 35 million people, and continues to spread at a rate of >2 million new infections/year. It is widely acknowledged that a protective vaccine would be the most effective means to reduce HIV-1 spread and ultimately eliminate the pandemic, while a therapeutic vaccine may help mitigate the clinical course of disease and lead to strategies of viral eradicati ...
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 27

 TERMINÉ 

Family-based intervention to improve healthy lifestyle and prevent Type 2 Diabetes amongst South Asians with central obesity and prediabetes (iHealth-T2D)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,

South Asians, who represent one-quarter of the world’s population, are at high risk of type-2 diabetes (T2D). Intensive lifestyle modification (healthy diet and physical activity) is effective at preventing T2D amongst South Asians with impaired glucose tolerance, but this approach is limited by high-cost, poor scalability and low impact on T2D burden. We will complete a cluster-randomised clinica ...
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 13

 TERMINÉ 

Holistic Approach of Spray Injection through a Generalized Multi-phase Framework (HAoS)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2019,

Development of fuel injection equipment (FIE) able to reduce pollutant emissions from liquid-fueled transportation and power generation systems is a top industrial priority in order to meet the forthcoming EU 2020 emission legislations. However, design of new FIE is currently constrained by the incomplete physical understanding of complex micro-scale processes, such as in-nozzle cavitation, primar ...
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 10

 TERMINÉ 

The Developing Human Connectome Project (dHCP)

Date du début: 1 sept. 2013, Date de fin: 31 août 2019,

Few advances in neuroscience could have as much impact as a precise global description of human brain connectivity and its variability. Understanding this ‘connectome’ in detail will provide insights into fundamental neural processes and intractable neuropsychiatric diseases.The connectome can be studied at millimetre scale in humans by neuroimaging, particularly diffusion and functional connectiv ...
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 4

 TERMINÉ 

DE-ENIGMA: Multi-Modal Human-Robot Interaction for Teaching and Expanding Social Imagination in Autistic Children (DE-ENIGMA)

Date du début: 1 févr. 2016, Date de fin: 31 juil. 2019,

Autism Spectrum Conditions (ASC, frequently defined as ASD - Autism Spectrum Disorders) are neurodevelopmental conditions, characterized by social communication difficulties and restricted and repetitive behaviour patterns. There are over 5 million people with autism in Europe – around 1 in every 100 people, affecting lives of over 20 million people each day. Alongside their difficulties, individu ...
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 9

 TERMINÉ 

Lifecourse biological pathways underlying social differences in healthy ageing (LIFEPATH)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

"The dramatic differentials in healthy ageing, quality of life and life expectancy between individuals of different socioeconomic groups, is a major societal challenge facing Europe. The overarching aim of the LIFEPATH project is to understand the determinants of diverging ageing pathways among individuals belonging to different socio-economic groups. This will be achieved via an original study de ...
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 18

 TERMINÉ 

Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging (DYNAHEALTH)

Date du début: 1 avr. 2015, Date de fin: 31 mars 2019,

The Gluco-Psychosocial Axis (GPA) concerns the interplay of factors determining glucose metabolism and insulin sensitivity and the neuroendocrine response resulting from exposure to psychosocial stress. A sub-optimal GPA influences the development of type 2 diabetes and related impairments with varying degrees of interplay between genetics and early growth (particularly adiposity and cognitive fun ...
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 14

 TERMINÉ 

eNHANCE - intention based enhancement of reaching and grasping in physically disabled people - personalized to maximize user performance (eNHANCE)

Date du début: 1 févr. 2015, Date de fin: 31 janv. 2019,

The eNHANCE project key objective is to symbiotically mechanically support and motivate people with motor impairments resulting from muscular or neural degeneration (e.g. stroke) to perform complex daily life tasks. Our system aims to assist the user in performing their daily-life interaction with the environment through an intelligent multi-modal adaptive interface controlled by a high performanc ...
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 11

 TERMINÉ 

Computational and functional annotation of genomic elements during development of the model vertebrate zebrafish (ZENCODE)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

The recent explosion of next generation sequencing (NGS) data has caught Europe unprepared and led to a critical shortage of computational biology expertise. As NGS methods are expected to become pervasive from basic science to personalised medicine there is an urgent need for highly skilled young scientists trained in both computational biology and experimental wet lab biology. Our network addres ...
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 11

 TERMINÉ 

Neuropathic pain: biomarkers and druggable targets within the endogenous analgesia system (NEUROPAIN)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

Neuropathic pain has a high incidence in Europe and often affects the patient’s emotional balance and quality of life. Recent meta-analyses have shown that conventional analgesic drugs are not sufficiently effective in these patients and are limited by serious side effects. The search for new analgesics is extremely difficult despite identification of several new potential targets and enormous inv ...
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 12

 TERMINÉ 

TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development (TBVAC2020)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Express ...
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 49

 TERMINÉ 

Models of Child Health Appraised (MOCHA)

Date du début: 1 juin 2015, Date de fin: 30 nov. 2018,

Children’s health affects the future of Europe – children are citizens, future workers, parents and carers. Children are dependent on society to provide effective health services (UN Convention on the Rights of the Child). Models of child primary health care vary widely across Europe based on two broad alternatives (primary care paediatricians or generic family doctors), and a variety of models of ...
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 20

 TERMINÉ 

Targets and biomarkers for antiepileptogenesis (EPITARGET)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Epilepsy is a devastating condition affecting over 50 million people worldwide. This multidisciplinary project is focused on the process leading to epilepsy, epileptogenesis, in adults. Our main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Our central premise and vision is that a comb ...
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 20

 TERMINÉ 

Human Brain Project Specific Grant Agreement 1 (HBP SGA1)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses I ...
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 126

 TERMINÉ 

Graphene-based disruptive technologies (GrapheneCore1)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CS ...
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 158

 TERMINÉ 

How force regulates cell function: a molecular and cellular outlook (ForceRegulation)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2018,

Force is ubiquitous in nature and physical stimuli are crucial for cell function. How cells process forces determines key physiological processes such as cell growth and differentiation, in which cells divide or differentiate according to the chemical and physical cues cells receive from the extracellular matrix. Physical stimuli have also been involved in the development of pathological processes ...
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 3

 TERMINÉ 

Preparing for Extreme And Rare events in coastaL regions (PEARL)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

"Coastal floods are one of the most dangerous and harmful natural hazards affecting urban areas adjacent to shorelines. Rapid urbanisation combined with climate change and poor governance means a significant increase in the risk of local surface flooding coinciding with high water levels in rivers and high tide or storm surges from the sea, posing a greater risk of devastation to coastal communiti ...
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 26

 TERMINÉ 

QUantitative Imaging in Cancer: CONnecting CEllular Processes with Therapy (QUIC-CONCEPT)

Date du début: 1 sept. 2011, Date de fin: 31 déc. 2017,

The QuIC-ConCePT consortium has 2 objectives: 1.(90% of resource, WP2-5) to qualify 3 specific imaging biomarkers (IBs) of tumour cell proliferation, apoptosis, and necrosis, to allow drug developers to demonstrate reliably modulation of these pathologic processes in tumours in patients in realistic trials. Our vision for January 2016 is that drug developers can incorporate these IBs for decision- ...
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 26

 TERMINÉ 

PHYSICAL ACTIVITY THROUGH SUSTAINABLE TRANSPORT APPROACHES (PASTA)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

This project focuses on the systematic promotion and facilitation of active mobility (AM) (i.e. walking and cycling including the combination with public transport use) as an innovative approach to integrate physical activity (PA) into individuals’ everyday lives. In contrast to sports or exercise, AM requires less time and motivation, since AM provides both convenience as a mode of transport, and ...
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 18

 TERMINÉ 

Stem-cell based therapy for kidney repair (STELLAR)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

Chronic kidney disease (CKD) affects 8% of the European population and ultimately results in renal failure due to progressive fibrosis. CDK carries a high mortality risk and the number of affected people rises, increasing the demand on renal replacement therapies while the number of available donor organs stays stable.The STELLAR consortium proposes to develop an alternative to renal replacement ...
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 15

 TERMINÉ 

Advanced Immunization Technologies (ADITEC)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2017,

Vaccines so far have been developed mostly by following an empiric approach. To prevent and possibly cure unresolved and emerging infectious diseases we need to fully exploit the potential of the human immune system. Progress in science and technology makes it possible to achieve what was previously deemed impossible. The scope of this project is to produce knowledge necessary to develop novel and ...
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 53

 TERMINÉ 

Enhanced exposure assessment and omic profiling for high priority environmental exposures in Europe (EXPOSOMICS)

Date du début: 1 nov. 2012, Date de fin: 30 avr. 2017,

This project aims to predict individual disease risk related to the environment, by characterizing the external and internal exposome for common exposures (air and drinking water contaminants) during critical periods of life, including in utero. A large amount of health data is now available from longitudinal cohorts in both children and adults, with detailed information on risk factors, confounde ...
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 15

 TERMINÉ 

Biomaterials for Tracheal Replacement in Age-related Cancer via a Humanly Engineered Airway (BIOtrachea)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,

Age-related cancers, especially of the trachea, are neoplastic lesions that significantly impact upon the lives of thousands of European patients each year. Unfortunately, most present with inoperable lesions for which median survival is less than 12 months. Based on our previous clinically successful experiences with in vivo completely tissue engineered tracheal replacement in benign tracheal dis ...
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 13

 TERMINÉ 

VPH Dementia Research Enabled by IT (VPH-DARE@IT)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,

The DementiA Research Enabled by IT project responds to the European Parliament's 2011 resolution for a European Initiative on Alzheimer's disease and other dementias, and the EU Year of the Brain 2014 Initiative. It delivers the first patient-specific predictive models for early differential diagnosis of dementias and their evolution. Its mechanistic/phenomenological models of the ageing brain ac ...
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 22

 TERMINÉ 

Deciphering the ubiquitin code of the TNF receptor signalling complex and its functional role in inflammation and immunity (UB-DECODED)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,

Tumour necrosis factor (TNF) is a cytokine with important functions in inflammation, immunity and cancer. Signalling processes mediated by ubiquitin are crucial for TNF signalling. The seven lysine (K) residues and the N-terminus of ubiquitin can be used to form ubiquitin chains. Employing a method newly developed in our laboratory we identified the presence of four of these ubiquitin chain linkag ...
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 3

 TERMINÉ 

Integrated Approaches to Food Allergen and Allergy Risk Management (IFAAM)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

Up to 20 million European citizens suffer from food allergy. However management of both food allergy (by patients and health practitioners) and allergens (by industry) is thwarted by lack of evidence to either prevent food allergy developing or protect adequately those who are already allergic. iFAAM will develop evidence-based approaches and tools for MANAGEMENT of ALLERGENS in FOOD and integrate ...
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 46

 TERMINÉ 

Co-morbidity in relation to Aids (COBRA)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

Persons with HIV on combination antiretroviral therapy (cART) are at increased risk of the premature development of age-associated non-communicable comorbidities (AANCC), including cardiovascular, chronic kidney, liver and pulmonary disease, diabetes mellitus, osteoporosis, non-AIDS associated malignancies, and neurocognitive impairment. It has therefore been hypothesised that such individuals, de ...
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 12

 TERMINÉ 

Brazilian-European partnership in Dynamical Systems (BREUDS)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

"This is a project for a partnership between leading Brazilian and European research groups in dynamical systems, a prominent subject in mathematics. An extensive consortium of European and Brazilian institutions will collaborate to provide world leading critical mass and support for research on the very forefront of the field. Work Packages reflect parallel priorities in the research. Transfer o ...
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 22

 TERMINÉ 

Network Topology Complements Genome as a Source of Biological Information (BIONET)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

...data and hence complement biological information that can be extracted from sequence. I propose to exploit these new techniques for biological applications in collaboration with experimentalists at Imperial College London: 1. aligning biological networks of species whose genomes are closely related, but that have very different phenotypes, in order to uncover systems-level factors that contribut ...
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 3

 TERMINÉ 

Biomarkers For Enhanced Vaccine Safety (BIOVACSAFE)

Date du début: 1 mars 2012, Date de fin: 31 déc. 2016,

BioVacSafe is a concise consortium of selected academic, public, and SME participants used to co-working in industry-led projects, organised into focused Activity Cores to generate knowledge and tools to benchmark licensed vaccine reactogenicity, and create practical and generalizable guidelines and techniques to enhance immunosafety of novel vaccines from pre-development to post-marketing surveil ...
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 24

 TERMINÉ 

Collaborative Network for Training in Electronic Skin Technology (CONTEST)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

"Future electronic systems will be bendable and conformable. They will be wearable, disposable, and ubiquitous. CONTEST will train young researchers in the fast expanding field of flexible and large area electronics with emphasis on “wearable” devices.Training will be implemented through well-defined work packages covering critical aspects of flexible electronics, converging towards an electronica ...
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 7

 TERMINÉ 

Promoting the Scientific Exploration of Computational Creativity (PROSECCO)

Date du début: 1 mars 2013, Date de fin: 31 août 2016,

Creativity is a long-cherished and widely-studied aspect of human behavior that allows us to re-invent the familiar and to imagine the new. Computational Creativity (CC) is a recent but burgeoning area of creativity research that brings together academics and practitioners from diverse disciplines, genres and modalities, to explore the potential of computers to be autonomously creative or to colla ...
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 8

 TERMINÉ 

NEURAL TRANSPLANTATION IN THE TREATMENT OF PATIENTS WITH PARKINSON’S DISEASE (TRANSEURO)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2016,

There are currently no cures for Parkinson's disease (PD) but one of the most effective reparative therapies in patients to date has been with allotransplants of dopamine (DA) neuroblasts obtained from fetal ventral mesencephalic (VM) tissue. However, this cell transplantation approach has given inconsistent results, with some patients doing extremely well and coming off anti-PD medication for yea ...
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 15

 TERMINÉ 

Techno-economic Assessment of CO2 Quality Effect on its Storage and Transport (CO2QUEST)

Date du début: 1 mars 2013, Date de fin: 30 juin 2016,

The CO2QUEST proposal addresses the fundamentally important issues regarding the impact of the typical impurities in the gas or dense phase CO2 stream captured from fossil fuel power plants on its safe and economic transportation and storage.The proposed work programme will focus on the development of state-of-the art mathematical models backed by laboratory and industrial-scale experimentation ut ...
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 10

 TERMINÉ 

Microbicide Optimization Through Innovative Formulation for Vaginal and Rectal Delivery (MOTIF)

Date du début: 1 oct. 2012, Date de fin: 31 mars 2016,

"The 40% protection against HIV-1 infection with vaginally-applied tenofovir gel demonstrated in the CAPRISA004 trial, has emphasized development of anti-retroviral (ARV)-based microbicides. Combining ARVs in a single product may provide increased protection. Development of a generally applicable formulation platform for combining ARVs (even if chemically incompatible) and understanding of the pro ...
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 9

 TERMINÉ 

Addictions and Lifestyles In Contemporary Europe – Reframing Addictions Project (ALICE RAP)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,

ALICE RAP is a Europe wide project of 43 partner research institutions involving 107 researchers from 25 European countries providing 1000 months of a plurality of scientific endeavour to analyse the place and challenges of addictions and lifestyles to the cohesion, organization and functioning of contemporary European society. Through integrated multidisciplinary research, a wide range of factors ...
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 46

 TERMINÉ 

Sarcomere based Signals in Muscle Remodelling (SARCOSI)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,

The sarcomere is the structural unit of striated muscle tissues where thick and thin filaments cooperate to achieve muscle contraction. Recently it is becoming increasingly clear that sarcomeres have in addition to muscle contraction also important signaling functions: Stretch and strain sensing signalosomes are assembled by the giant muscle proteins titin and nebulin, that in turn are embedded in ...
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 14

 TERMINÉ 

Exploring the Terauniverse with the LHC, Astrophysics and Cosmology (Terauniverse)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,

The visible matter in the Universe is well described by the Standard Model, but this leaves open major questions in both particle physics and cosmology that may be answered by new physics at the Tera-electron-Volt range: the Terascale. The Large Hadron Collider (LHC) will soon open a new stage in humanity’s direct exploration of the fundamental physical laws at Terascale energies, which governed t ...
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 5