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12 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Multimodal Imaging of rare Synucleinopathies (MultISyn)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Despite remarkable progress in the understanding of the molecular pathogenesis of neurodegenerative diseases (NDD), no causative or disease-modifying treatment is currently available. Aggregation of misfolded proteins are thought to play a crucial role in the pathogenesis, but attempts to exploit this knowledge for novel treatments have not been successful. Also, pathogenetically relevant biomarke ...
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 9

 TERMINÉ 

Integrated European –omics research project for diagnosis and therapy in rare neuromuscular and neurodegenerative diseases (Neuromics)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

Neurodegenerative (ND) and neuromuscular (NM) disease is one of the most frequent classes of rare diseases, affecting life and mobility of 500,000 patients in Europe and millions of their caregivers, family members and employers. This NEUROMICS project brings together the leading research groups in Europe, five highly innovative SMEs and relevant oversea experts using the most sophisticated Omics ...
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 20

 TERMINÉ 

Industrial Academic Initial Training Network towards focused treatment of age-related motor symptoms (MOVING BEYOND)

Date du début: 1 oct. 2012, Date de fin: 31 janv. 2017,

Gait and postural control impairments, and falls are ubiquitous among the elderly, and lead to enormous personal, occupational and health care burden. Especially patients with PD are severely affected by the progressive deterioration of these gait and postural control mechanisms. Elucidating mechanisms of age- and disease-related motor control impairments and devising focussed treatment strategies ...
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 9

 TERMINÉ 

EID on the advanced science and technology of rat models for neurodegenerative diseases (PhenoRat)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

One of the most important bottlenecks for finding more effective drugs for brain disorders is the development of model systems that translate to human pathology and are predictive of clinical efficacy. To address this bottleneck PhenoRat will focus on the generation, characterisation and validation of transgenic rat models of two neurodegenerative diseases: Huntington disease (HD) and spinocerebel ...
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 2

 TERMINÉ 

TreatPolyQ – Industrial Academic Initial Training Network towards treatment of Polyglutamine Diseases (TREATPOLYQ)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

Protein aggregation is a hallmark of many late onset neurodegenerative disorders including Parkinson’s Disease (PD), Alzheimer’s Disease (AD), amyotrophic lateral sclerosis (ALS), prion diseases as well as the group of polyglutamine diseases (polyQ). The aim of this proposal is to create a network of European partners bridging important basic mechanisms involved in proteinopathies, research of mod ...
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 17

 TERMINÉ 

SENSE-PARK: Supporting and Empowering Parkinson patients in their home environment using a Novel SEnsory information system that monitors daily-life-relevant parameters of PARKinson disease and their (SENSE-PARK)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2014,

Parkinson's disease (PD) is the second most common neurodegenerative disease, and prevalence increases with age. This leads, in an aging society, to increasing personal, social and economic burden. To date, basically only symptomatic treatment is available, which application almost always leads to the feeling of dependence and lose of self-control in (a) person(s) with PD (PwP's). A further shortc ...
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 7

 TERMINÉ 

Academic-Industrial Training Network on Alpha-Synuclein-related Brain Diseases (NEURASYNC)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,

"Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. It is characterized pathologically by the accumulation of aggregated conformations of the presynaptic protein alpha-synuclein (ASYN) in cytoplasmic inclusions termed Lewy Bodies (LBs). Furthermore, aberrant aggregated species of ASYN accumulate in various disease states, such as Multiple System Atrophy, Diffuse LB Dise ...
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 11

 TERMINÉ 

European Project on Mendelian Forms of Parkinson’s Disease (MEFOPA)

Date du début: 1 avr. 2010, Date de fin: 30 sept. 2013,

"The Collaborative Project on Mendelian Forms of Parkinson’s Disease (MEFOPA) will bring together the major groups in Europe with a track-record in basic and clinical research on rare Mendelian forms of Parkinson’s disease (PD) in order to identify and validate relevant disease-related molecular pathways, drug-targets and biomarkers for disease susceptibility and progression.. Over the last years ...
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 27

 TERMINÉ 

IAPP on novel genetic and phenotypic markers of Parkinson's disease and Essential Tremor (MarkMD)

Date du début: 1 mars 2009, Date de fin: 28 févr. 2013,

Copy number variations (CNV) are ubiquitously found throughout in the human genome. Their role in monogenic as well as multifactorial disorders as potential disease modifier is more and more stressed (Abecasis et al., 2007). In order to investigate the role of CNV in Parkinson’s disease (PD) and Essential Tremor (ET), two frequent neurological diseases, MARKMD brings together the unique expertises ...
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 2

 TERMINÉ 

Initial Training Network on therapeutic approaches and predictive models for neurodegenerative diseases (NEUROMODEL)

Date du début: 15 oct. 2008, Date de fin: 14 oct. 2012,

"Neurodegenerative diseases such as Parkinson’s disease (PD) and Huntington’s disease (HD) still lack treatments that are disease modifying. The proposed network is going to address the three most important bottlenecks for finding more effective medicine in brain disorders. Those are: (i) identification and validation of pre-symptomatic and surrogate marker for disease progression, (ii) Develo ...
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 11

 TERMINÉ 

Mitochondrial dysfunction in neurodegenerative diseases: towards new therapeutics (Mitotarget)

Date du début: 1 févr. 2009, Date de fin: 31 mars 2012,

Mitochondrial dysfunction is a major hallmark of various neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, Huntington’s diseases or Amyotrophic Lateral Sclerosis (ALS). However linking mitochondrial dysfunction to the pathogenesis of some of these diseases still needs to be elucidated. Furthermore, in pathologies where this link is already established, the question re ...
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 19

 TERMINÉ 

High throughput molecular diagnostics in individual patients for genetic diseases with heterogeneous clinical presentation (TECHGENE)

Date du début: 1 févr. 2009, Date de fin: 31 janv. 2012,

"Since the sequencing of the human genome has been completed the demand for genetic analysis in the human health care system is drastically increasing, and the extension of molecular genetic diagnostics is urgently needed. However, the majority of genetic diseases is molecularly and clinically highly heterogeneous, and until recently the available techniques lacked the required capacity to analyze ...
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 12