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Eight partners from six different EU countries will converge in NotchIT, a multi-site ITN aimed to increase the knowledge of cellular and molecular mechanisms by which Notch signaling regulates the development and pathology of different tissues. Notch signaling plays a key role in cell-fate determination and differentiation of various cell types and aberrant Notch signaling is associated with path ...

Angiogenesis underlies almost all biological processes of morphogenesis, including those in tissue repair and regeneration. Physiological angiogenesis is controlled by a complex interplay between cells and their environment: the extracellular matrix (ECM) provides signaling via numerous ECM adhesion molecules and growth factors bound to ECM polysaccharide components; and cells locally degrade and ...