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 TERMINÉ 

Sweet Theranostics in Bitter Infections - Seek and Destroy (SWEETBULLETS)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2022,

Bacterial infections are now a global threat demanding novel treatments due to the appearance of resistances against antibiotics at a high pace. The ESKAPE pathogens are those with highest importance in the EU and chronic infections due to biofilm formation are a particular task. Noninvasive pathogen-specific imaging of the infected tissue is not clinically available. Its successful implementation ...
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 1

 TERMINÉ 

Precision Multi-Spectral Optoacoustic Tomography for Discovery Diagnosis and Intervention (PREMSOT)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The 2008 ERC Advanced Grant multispectral optoacoustic tomography (MSOT) yielded a novel modality for post-genomic small animal optical imaging, >110 peer-reviewed publications and several major awards including the 2014 Germany’s Innovation award. Since 2011 spin-off iThera Medical GmbH commercialized and placed MSOT systems in European, Asian and North American laboratories, making MSOT an inter ...
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 2

 TERMINÉ 

European Sudden Cardiac Arrest network: towards Prevention, Education and NEw Treatment (ESCAPE-NET)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Sudden cardiac arrest (SCA) causes ~20% of all deaths in Europe. SCA is lethal within minutes if left untreated and survival rates are presently only 5-20%. Therefore, there is a large medical need to improve SCA prevention and treatment. Designing effective individualized prevention and treatment strategies requires knowledge on genetic and environmental risk factors. So far, these efforts have b ...
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 17

 TERMINÉ 

Ocean Artificial Upwelling (Ocean artUp)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The productivity of the ocean is limited by the transport of nutrient-rich deep waters to the sun-lit surface layer. In large parts of the global ocean this transport is blocked by a temperature-induced density gradient, with warm light waters residing on top of heavier cold waters. These regions, which are referred to by scientists as ocean deserts, are presently expanding due to surface-ocean wa ...
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 1

 TERMINÉ 

Topographically-driven meteoric groundwater – An important geomorphic agent (MARCAN)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Topographically-driven meteoric (TDM) recharge is a key driver of offshore groundwater systems because sea level has been lower than at present for 80% of the last 2.6 million years. Groundwater has been implicated as an important agent in the geomorphic evolution of passive continental margins and the canyons that incise them. However, the geomorphic efficacy of groundwater remains dubious, and a ...
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 3

 TERMINÉ 

Integrated Arctic observation system (INTAROS)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2021,

The overall objective of INTAROS is to develop an integrated Arctic Observation System (iAOS) by extending, improving and unifying existing systems in the different regions of the Arctic. INTAROS will have a strong multidisciplinary focus, with tools for integration of data from atmosphere, ocean, cryosphere and terrestrial sciences, provided by institutions in Europe, North America and Asia. Sate ...
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 41

 TERMINÉ 

Hybrid Volumetric Optoacoustic-Ultrasound Tomography for Noninvasive Large-Scale Recording of Brain Activity with High Spatiotemporal Resolution (OPTOACOUSTOGENETICS)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

Non-invasive observation of fast spatiotemporal activity patterns of large neural populations distributed over entire brains is a longstanding goal of neuroscience. Not only would such abilities significantly promote our knowledge on brain function and its pathophysiology but they are also expected to accelerate development of novel therapies targeting neurological and neuropsychiatric disorders. ...
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 1

 TERMINÉ 

Targeting hypothalamic inflammation in obesity and diabetes (HypoFlam)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

Despite educational, political and biomedical research efforts, obesity, type 2 diabetes and related metabolic diseases are increasing worldwide at an alarming rate. Failure to deliver efficient and safe medical therapies is a result of our incomplete understanding of the pathogenesis of the metabolic syndrome. Current knowledge implicates impaired CNS control over appetite, body weight and system ...
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 1

 TERMINÉ 

Selecting genetic lesions with essential function for patients' leukaemia in vivo as targets for precision medicine (LeukaemiaTargeted)

Date du début: 1 août 2016, Date de fin: 31 juil. 2021,

In Europe, around two million individuals die from cancer each year. Cancer is a genetic disease and each patient's tumour contains several genetic lesions which are identified by next generation sequencing (NGS) and influence patient's outcome. A global current challenge lies in translating NGS data into benefit of cancer patients.As attractive novel therapeutic concept, precision medicine addres ...
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 2

 TERMINÉ 

Integration of climate change adaptation into the work of local authorities (LIFE LOCAL ADAPT)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

Background Responsibility for infrastructure is devolved to the regional or local level in many parts of the EU. However, many small and medium-sized authorities lack the knowledge and capacity to address the challenges posed by the need for climate change adaptation (CCA). LIFE LOCAL ADAPT has been designed to identify specific threats at local level and ...
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 7

 TERMINÉ 

Cellular and molecular mechanisms of metabolic immune activation triggering non-alcoholic steatohepatitis (NASH) and HCC (HepatoMetaboPath)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

Overweight and metabolic syndrome are reaching pandemic dimensions in industrialized countries and are rising in developing countries. Clinically these diseases can manifest in non-alcoholic fatty liver disease (NAFLD), the most frequent liver disease world-wide. A significant number of NAFLD patients develop non-alcoholic steatohepatitis (NASH), fibrosis and hepatocellular carcinoma (HCC), making ...
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 1

 TERMINÉ 

Generation of the CanPath prototype - a platform for predictive cancer pathway modeling (CanPathPro)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,

Recent developments in omics technologies demand implementation of systems biology approaches to facilitate analysis and interpretation of the generated complex datasets.This is essential for biotechnological as well as preclinical and clinical applications. In comparison to previous approaches, most cancer relevant studies are confined to pattern recognition or at best modelling of single pathway ...
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 9

 TERMINÉ 

Arctic Impact on Weather and Climate (Blue-Action)

Date du début: 1 déc. 2016, Date de fin: 28 févr. 2021,

Blue-Action will provide fundamental and empirically-grounded, executable science that quantifies and explains the role of a changing Arctic in increasing predictive capability of weather and climate of the Northern Hemisphere.To achieve this Blue-Action will take a transdisciplinary approach, bridging scientific understanding within Arctic climate, weather and risk management research, with key s ...
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 40

 TERMINÉ 

The European network for observing our changing planet (ERA-PLANET)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

In the last decade a significant number of projects and programmes in different domains of environmental monitoring and Earth observation have generated a substantial amount of data and knowledge on different aspects related to environmental quality and sustainability. Big data generated by in-situ or satellite platforms are being collected and archived with a plethora of systems and instruments m ...
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 38

 TERMINÉ 

New siRNA Nanotherapy for Inflammatory Bowel Diseases, targeting Janus kinase 3 (NEW DEAL)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2021,

Inflammatory bowel diseases (IBD) are the second most common immune-mediated disorders in Europe, affecting more particularly young people. The current therapies, including antibodies, show three main drawbacks: efficacy, tolerability and convenience. NEW DEAL solution will offer radical therapeutic progress for all IBD patients, thanks to the improved efficacy and increased safety of the specific ...
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 11

 TERMINÉ 

Network of Leading European AQUAtic MesoCOSM Facilities Connecting Mountains to Oceans from the Arctic to the Mediterranean (AQUACOSM)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Experimentation in mesocosms is arguably the single most powerful approach to obtain a mechanistic quantitative understanding of ecosystem-level impacts of stressors in complex systems, especially when embedded in long-term observations, theoretical models and experiments conducted at other scales. AQUACOSM builds on an established European network of mesocosm research infrastructures (RI), the FP ...
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 23

 TERMINÉ 

Towards enduring mouse resources and services advancing research into human health and disease (INFRAFRONTIER2020)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st ...
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 33

 TERMINÉ 

Terahertz RAdio communication using high ANistropy SPIn torque REsonators (TRANSPIRE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Current and future technological and societal demands require the transfer of vast amounts of data at speeds currently not available due to a lack of technology operating in the terahertz (THz) gap. TRANSPIRE will develop nano-scale THz-oscillators based on a new class of magnetic materials, which will function in this exact range and meet these demands. This will enable new functionalities with ...
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 4

 TERMINÉ 

Technology demonstration of large-scale photo-electrochemical system for solar hydrogen production (PECSYS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The objective of the project PECSYS is the demonstration of a system for the solar driven electrochemical hydrogen generation with an area >10 m². The efficiency of the system will be >6% and it will operate for six month showing a degradation below 100 cm²) and will be subject to extensive stability optimization. Especially, the use of innovative ALD based metal oxide sealing layers will be studi ...
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 6

 TERMINÉ 

Readiness of ICOS for Necessities of integrated Global Observations (RINGO)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The proposed project “Readiness of ICOS for Necessities of integrated Global Observations” (RINGO) aims to further development of ICOS RI and ICOS ERIC and foster its sustainability. The challenges are to further develop the readiness of ICOS RI along five principal objectives: 1. Scientific readiness. To support the further consolidation of the observational networks and enhance their quality. Th ...
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 26

 TERMINÉ 

ACCELERATing Europe's Leading Research Infrastructures (ACCELERATE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

CERIC-ERIC (CERIC) is a distributed research infrastructure for fundamental and applied research on novel materials and biomaterials. The RI has been in operation for 2 years and provides open access to a broad range of instruments and expertise across research communities, in order to support the research community world-wide in tackling the most challenging problems of materials research. The A ...
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 8

 TERMINÉ 

Natural Toxins and Drinking Water Quality - From Source to Tap (NaToxAq)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Clean drinking water is crucial to human health and wellbeing. The ambition of the NaToxAq ETN network is to expand the research basis for EU’s leading role in securing high quality drinking waters for its citizens. Focus is on natural toxins – a large group of emerging contaminants with unknown impact on drinking water resources. Both known toxins, like cyanotoxins, cyanogenic glucosides and terp ...
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 10

 TERMINÉ 

The nanoparticle-scope : a new integrated instrument for accurate and reproducible physico-chemical characterisation of nanoparticles (npSCOPE) (npSCOPE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The npSCOPE project aims at developing a new integrated instrument (the nanoparticle-scope) optimised for providing a complete physico-chemical characterisation of nanoparticles both in their pristine form or embedded in complex matrices such as biological tissues. Using sophisticated correlative data processing methodologies and algorithms based on statistical methods in conjunction with appropri ...
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 9

 TERMINÉ 

Hybrid optical and optoacoustic endoscope for esophageal tracking. (ESOTRAC)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

More than 450.000 people are diagnosed with esophageal cancer (EC) each-year worldwide and approximately 400.000 die from the disease. Esophageal cancer is the eighth most commonly diagnosed cancer, but it is the sixth leading cause of cancer-related death, with incidence rates steeply rising. Risk factors, including gastroesophageal reflux disease and Barrett’s esophagus, may diagnostically impli ...
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 9

 TERMINÉ 

European training Network for In situ imaGing of dynaMic processes in heterogeneous subsurfAce environments (ENIGMA)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The ENIGMA network will train a new generation of young researchers in the development of innovative sensors, field survey techniques and inverse modelling approaches. This will enhance our ability to understand and monitor dynamic subsurface processes that are key to the protection and sustainable use of water resources. ENIGMA focuses mainly on critical zone observation, but the anticipated tech ...
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 11

 TERMINÉ 

Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease (Foie Gras)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

FOIE GRAS provides innovative training for 13 early stage researchers (ESRs) to answer two critical and unanswered questions: a) Is hepatic bioenergetic remodelling involved in NAFLD pathogenesis, and target for stratification or therapeutic/lifestyle interventions? and b) Is the disruption of the gut-liver axis involved in NAFLD progression? In Western Societies, there has been a recent surge of ...
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 11

 TERMINÉ 

European Research Area for Climate Services (ERA4CS)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Within the European Research Area (ERA), the ERA4CS Consortium is aiming to boost, research for Climate Services (CS), including climate adaptation, mitigation and disaster risk management, allowing regions, cities and key economic sectors to develop opportunities and strengthen Europe’s leadership. CS are seen by this consortium as driven by user demands to provide knowledge to face impacts of cl ...
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 46

 TERMINÉ 

Smart high-frequency environmental sensor networks for quantifying nonlinear hydrological process dynamics across spatial scales (HiFreq)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

Regulators and industries are challenged by the difficulty to analyse and predict the impact of nonlinear environmental processes on short-term and long-term responses of ecosystems to environmental change. Until very recently, the development of most conventional monitoring, forecasting and prediction tools has been based on the assumption of stationary environmental systems. In the context of gl ...
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 18

 TERMINÉ 

Analytical and Characterisation Excellence in nanomaterial risk assessment: A tiered approach (ACEnano)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

An increasing number of nanomaterials (NMs) are entering the market in every day products spanning from health care and leisure to electronics, cosmetics and foodstuff. Nanotechnology is a truly enabling technology, with unlimited potential for innovation. However, the novelty in properties and forms of NMs makes the development of a well-founded and robust legislative framework to ensure safe dev ...
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 27

 TERMINÉ 

European Climate Observations, Modelling and Services - 2 (ECOMS2)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2020,

The ECOMS2 Action will coordinate and support Europe’s knowledge base to enable better management of climate-related risks and opportunities thereby creating greater social and economic value. ECOMS2 has 4 main objectives:1. Develop a European framework for Earth-system modelling and climate service activities. The framework will be built around a managed network of European, national and internat ...
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 12

 TERMINÉ 

SeaDataCloud - Further developing the pan-European infrastructure for marine and ocean data management (SeaDataCloud)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

The SeaDataNet pan-European infrastructure has been developed by NODCs and major research institutes from 34 countries. Over 100 marine data centres are connected and provide discovery and access to data resources for all European researchers. Moreover, SeaDataNet is a key infrastructure driving several portals of the European Marine Observation and Data network (EMODnet), initiated by EU DG-MARE ...
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 57

 TERMINÉ 

Improving the flow in the pipeline of the next generation of marine biodiscovery scientists (MarPipe)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

MarPipe is a consortium of 11 partners (IBP-CNR, SZN, UiT, UNIABDN, GEOMAR, KULeuven, UCC, eCOAST, MEDINA, MicroDish, Italbiotec) based in 8 countries (I, N, UK, D, B, IRL, E, NL), including 3 from the non-academic sector. We will train 11 ESRs in marine drug-discovery, providing these researchers with unique skills toward becoming world leaders in this research field and to advance their careers ...
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 11

 TERMINÉ 

Advanced Prediction in Polar regions and beyond: Modelling, observing system design and LInkages associated with ArctiC ClimATE change (APPLICATE)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

Arctic climate change increases the need of a growing number of stakeholders for trustworthy weather and climate predictions, both within the Arctic and beyond. APPLICATE will address this challenge and develop enhanced predictive capacity by bringing together scientists from academia, research institutions and operational prediction centres, including experts in weather and climate prediction and ...
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 16

 TERMINÉ 

effiCient mineral processing and Hydrometallurgical RecOvery of by-product Metals from low-grade metal contaIning seCondary raw materials (CHROMIC)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

Europe is faced with the challenge of sustaining a secure supply of by-product metals, which play a fundamental role in the competitiveness of the manufacturing sector and innovations in high-tech sectors. To loosen the growth restrictions imposed by the inflexible supply from primary mining, alternative sources for these metals must be explored. At the same time a wealth of metals is entrapped wi ...
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 11

 TERMINÉ 

CLean INland SHipping (LIFE CLINSH)

Date du début: 1 sept. 2016, Date de fin: 31 août 2020,

Background Inland Waterway Transport (IWT) causes considerable emissions of the air pollutants NOx and PM10. Many European regions are struggling to tackle air quality problems, though the often expensive measures implemented to meet air quality limit values are mainly directed at industry and road transport. However, it is increasingly recognised that in ...
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 17

 TERMINÉ 

A DECentralIzed management Scheme for Innovative Valorization of urban biowastE (DECISIVE)

Date du début: 1 sept. 2016, Date de fin: 31 août 2020,

The growing attractiveness of cities leads to increasing population, thus rising energetic and food demands in urban areas. This makes urban waste management increasingly challenging, both in terms of logistics and environmental or health impacts. To decrease the cities’ environmental impacts and to contribute to a better resilience of urban areas towards energy or food supply crisis, waste manage ...
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 13

 TERMINÉ 

Tribbles Research and Innovation Network (TRAIN)

Date du début: 1 sept. 2016, Date de fin: 31 août 2020,

This proposal was developed in the context of the medical need to tackle the clinical consequences of obesity-related diseases more holistically. Dysregulation of common molecular pathways that govern the physiological functioning of adipocytes, immune cells and prostate epithelium cells have been reported in immuno-metabolic disease (such as obesity) and several cancers. The individual projects ...
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 10

 TERMINÉ 

Baltic Consortium on Promoting Gender Equality in Marine Research Organisations (Baltic Gender)

Date du début: 1 sept. 2016, Date de fin: 31 août 2020,

Baltic Gender is a consortium of research organisations and higher education institutions from the Baltic Sea Region aiming at reducing gender segregation and gender inequalities in Marine Science and Technology. The diversity of the consortium members (from Nordic, Continental and Eastern countries) with regard to gender equality policies and practices as well as gatekeeping provides an excellent ...
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 8

 TERMINÉ 

Volcano dome growth, collapse and coupled processes (VOLCAPSE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

The construction of volcanoes, i.e. the intrusive and eruptive growth, can be intermittently interrupted by destructive events. Dome building volcanoes, in specific, grow by magma extrusion and are partially destroyed again, posing a significant hazard in form of pyroclastic flows and other processes. The explosion at Merapi (Indonesia) in 2010, and at Colima volcano (Mexico) in 2013 are good exam ...
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 1

 TERMINÉ 

Mechanisms of Gene Silencing by the Glucocorticoid Receptor (SILENCE)

Date du début: 1 août 2015, Date de fin: 31 juil. 2020,

I propose to decipher the unresolved molecular paradox of positive versus negative gene regulation by the Glucocorticoid Receptor (GR). GR is one of the most potent anti-inflammatory drug targets in clinical use today, and one of the most powerful metabolic regulators. Unfortunately, its unique ability to efficiently shut off inflammatory gene expression is accompanied by serious side effects. The ...
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 1