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 TERMINÉ 

Precision Multi-Spectral Optoacoustic Tomography for Discovery Diagnosis and Intervention (PREMSOT)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The 2008 ERC Advanced Grant multispectral optoacoustic tomography (MSOT) yielded a novel modality for post-genomic small animal optical imaging, >110 peer-reviewed publications and several major awards including the 2014 Germany’s Innovation award. Since 2011 spin-off iThera Medical GmbH commercialized and placed MSOT systems in European, Asian and North American laboratories, making MSOT an inter ...
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 2

 TERMINÉ 

European Sudden Cardiac Arrest network: towards Prevention, Education and NEw Treatment (ESCAPE-NET)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Sudden cardiac arrest (SCA) causes ~20% of all deaths in Europe. SCA is lethal within minutes if left untreated and survival rates are presently only 5-20%. Therefore, there is a large medical need to improve SCA prevention and treatment. Designing effective individualized prevention and treatment strategies requires knowledge on genetic and environmental risk factors. So far, these efforts have b ...
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 17

 TERMINÉ 

Hybrid Volumetric Optoacoustic-Ultrasound Tomography for Noninvasive Large-Scale Recording of Brain Activity with High Spatiotemporal Resolution (OPTOACOUSTOGENETICS)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

Non-invasive observation of fast spatiotemporal activity patterns of large neural populations distributed over entire brains is a longstanding goal of neuroscience. Not only would such abilities significantly promote our knowledge on brain function and its pathophysiology but they are also expected to accelerate development of novel therapies targeting neurological and neuropsychiatric disorders. ...
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 1

 TERMINÉ 

Targeting hypothalamic inflammation in obesity and diabetes (HypoFlam)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

Despite educational, political and biomedical research efforts, obesity, type 2 diabetes and related metabolic diseases are increasing worldwide at an alarming rate. Failure to deliver efficient and safe medical therapies is a result of our incomplete understanding of the pathogenesis of the metabolic syndrome. Current knowledge implicates impaired CNS control over appetite, body weight and system ...
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 1

 TERMINÉ 

Selecting genetic lesions with essential function for patients' leukaemia in vivo as targets for precision medicine (LeukaemiaTargeted)

Date du début: 1 août 2016, Date de fin: 31 juil. 2021,

In Europe, around two million individuals die from cancer each year. Cancer is a genetic disease and each patient's tumour contains several genetic lesions which are identified by next generation sequencing (NGS) and influence patient's outcome. A global current challenge lies in translating NGS data into benefit of cancer patients.As attractive novel therapeutic concept, precision medicine addres ...
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 2

 TERMINÉ 

Cellular and molecular mechanisms of metabolic immune activation triggering non-alcoholic steatohepatitis (NASH) and HCC (HepatoMetaboPath)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

Overweight and metabolic syndrome are reaching pandemic dimensions in industrialized countries and are rising in developing countries. Clinically these diseases can manifest in non-alcoholic fatty liver disease (NAFLD), the most frequent liver disease world-wide. A significant number of NAFLD patients develop non-alcoholic steatohepatitis (NASH), fibrosis and hepatocellular carcinoma (HCC), making ...
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 1

 TERMINÉ 

Generation of the CanPath prototype - a platform for predictive cancer pathway modeling (CanPathPro)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,

Recent developments in omics technologies demand implementation of systems biology approaches to facilitate analysis and interpretation of the generated complex datasets.This is essential for biotechnological as well as preclinical and clinical applications. In comparison to previous approaches, most cancer relevant studies are confined to pattern recognition or at best modelling of single pathway ...
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 9

 TERMINÉ 

Towards enduring mouse resources and services advancing research into human health and disease (INFRAFRONTIER2020)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st ...
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 33

 TERMINÉ 

Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease (Foie Gras)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

FOIE GRAS provides innovative training for 13 early stage researchers (ESRs) to answer two critical and unanswered questions: a) Is hepatic bioenergetic remodelling involved in NAFLD pathogenesis, and target for stratification or therapeutic/lifestyle interventions? and b) Is the disruption of the gut-liver axis involved in NAFLD progression? In Western Societies, there has been a recent surge of ...
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 11

 TERMINÉ 

Hybrid optical and optoacoustic endoscope for esophageal tracking. (ESOTRAC)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

More than 450.000 people are diagnosed with esophageal cancer (EC) each-year worldwide and approximately 400.000 die from the disease. Esophageal cancer is the eighth most commonly diagnosed cancer, but it is the sixth leading cause of cancer-related death, with incidence rates steeply rising. Risk factors, including gastroesophageal reflux disease and Barrett’s esophagus, may diagnostically impli ...
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 9

 TERMINÉ 

Tribbles Research and Innovation Network (TRAIN)

Date du début: 1 sept. 2016, Date de fin: 31 août 2020,

This proposal was developed in the context of the medical need to tackle the clinical consequences of obesity-related diseases more holistically. Dysregulation of common molecular pathways that govern the physiological functioning of adipocytes, immune cells and prostate epithelium cells have been reported in immuno-metabolic disease (such as obesity) and several cancers. The individual projects ...
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 10

 TERMINÉ 

Mechanisms of Gene Silencing by the Glucocorticoid Receptor (SILENCE)

Date du début: 1 août 2015, Date de fin: 31 juil. 2020,

I propose to decipher the unresolved molecular paradox of positive versus negative gene regulation by the Glucocorticoid Receptor (GR). GR is one of the most potent anti-inflammatory drug targets in clinical use today, and one of the most powerful metabolic regulators. Unfortunately, its unique ability to efficiently shut off inflammatory gene expression is accompanied by serious side effects. The ...
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 1

 TERMINÉ 

European Joint Programme for the Integration of Radiation Protection Research (CONCERT)

Date du début: 1 juin 2015, Date de fin: 31 mai 2020,

The proposed European Concerted Programme on Radiation Protection Research (acronym: CONCERT) aims to contribute to the sustainable integration of European and national research programmes in radiation protection. It will do so by focusing resources and efforts in five key directions:• Bring together the elements of the European scientific communities in the fields of radiation effects and risks, ...
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 36

 TERMINÉ 

Application of omics-based strategies for improved diagnosis and treatment of endocrine hypertension (ENSAT-HT)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Arterial hypertension affects up to 45% of the general population and is responsible for 7.1 million deaths per year worldwide. Although a large therapeutic arsenal exists, blood pressure control is sub-optimal in up to two thirds of patients. Yet, even small increments in blood pressure are associated with increased cardiovascular risk, with 62% of cerebrovascular disease and 49% of ischemic hear ...
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 13

 TERMINÉ 

RELapses prevENTion in chronic autoimmune disease: common mechanisms and co-morbidities (RELENT)

Date du début: 1 nov. 2015, Date de fin: 30 avr. 2020,

RELENT is multidisciplinary group of scientists and clinical investigators whose goal is to develop individualized treatment for chronic autoimmune diseases, such as rheumatoid arthritis and vasculitis, that cause considerable mortality and morbidity, both from uncontrolled disease and treatment associated co-morbidities, like infection and malignancy. This requires the need to stratify patients b ...
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 14

 TERMINÉ 

Smart Tools for Gauging Nano Hazards (SmartNanoTox)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete NM characterisation with consequent careful and well-controlled in vivo experiments. A significant progress in the ability of the robust nanotoxicity prediction can be achieved using modern approaches based on on ...
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 12

 TERMINÉ 

Chromatin and MetabolismChromatin-metabolism interactions as targets for healthy living (ChroMe)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

Metabolic disorders are at pandemic levels. Based on recent estimates, ~50% of Europeans are overweight, 20% are obese and 10% have type II diabetes. Obesity and insulin resistance impact European health to the tune of €110 billion per year. These disorders have genetic, nutritional and lifestyle causes. However, the molecular mechanisms that link nutrients and lifestyle to gene activity and chrom ...
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 12

 TERMINÉ 

Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities. (HEP-CAR)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Hepatocellular carcinoma (HCC) is the most common liver malignancy, with an estimated 750,000 new cases and 695,000 deaths per year, rating third in incidence and mortality in the world. Whilst incidence and mortality for other cancers are declining, HCC represents an increasing public health problem in Europe with men having a higher incidence than women. Several liver diseases lead to HCC and be ...
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 9

 TERMINÉ 

Accelerated Early staGe drug diScovery (AEGIS)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

The development of effective novel drugs - especially for rare and neglected diseases - is one of the biggest challenges of the upcoming decades, as illustrated by the recent Ebola outbreak. Moreover, European innovation in new drug registrations is dramatically falling behind compared to the US and Asia.The principal aim of the AEGIS ITN is to implement the first comprehensive, intersectoral cros ...
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 11

 TERMINÉ 

Big Data in Chemistry (BIGCHEM)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

The advent of the big data era in chemistry and the life sciences requires the development of new computational analysis methods, which are not only of scientific, but also economic relevance. Currently, the international data market already grows six times faster than the entire IT sector, and growth rates further increase. Achieving and sustaining a leadership positions in the big data arena rep ...
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 9

 TERMINÉ 

Coordinated Research Infrastructures Building Enduring Life-science services (CORBEL)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

The social and economic challenges of ageing populations and chronic disease can only be met by translation of biomedical discoveries to new, innovative and cost effective treatments. The ESFRI Biological and Medical Research Infrastructures (BMS RI) underpin every step in this process; effectively joining scientific capabilities and shared services will transform the understanding of biological m ...
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 39

 TERMINÉ 

Studying, Measuring and Altering Consciousness through information theory in the electrical brain (LUMINOUS)

Date du début: 1 mars 2016, Date de fin: 31 août 2019,

What is consciousness? Can it be measured? While humankind has struggled with these questions for millennia, our project will focus on more modest but nonetheless ambitious and related goals. Inspired by recent developments in neuroscience and the potential role of fundamental concepts such as information integration and algorithmic complexity, we will study, model, quantify, and alter observable ...
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 8

 TERMINÉ 

Research Infrastructures for Phenotyping, Archiving and Distribution of Mouse Disease Models - Promoting International Cooperation and User Engagement to Enhance Biomedical Innovation (IPAD-MD)

Date du début: 1 juin 2015, Date de fin: 31 mai 2019,

The IPAD-MD project addresses cooperation and coordination between the pan-European INFRAFRONTIER Research Infrastructure and complementary research infrastructures in America, Asia and Australia, contributing to the global effort of the International Mouse Phenotyping Consortium (IMPC). In order to increase the reach of INFRAFRONTIER, IPAD-MD will also reach out to complementary infrastructures a ...
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 11

 TERMINÉ 

ANAEROBIC POLLUTANT DEGRADATION WITH OXYGEN (POLLOX)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

"Contamination with organic pollutants is widespread in nature and a notorious threat to our water resources. Two central paradigms are currently understood to control biodegradation in groundwater and sediments: (i) Redox gradients and interphases between compartments are hot-spots for contaminant breakdown, and (ii) biodegradation is primarily limited by local electron acceptor availability, in ...
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 1

 TERMINÉ 

Identifying and Overcoming Bottlenecks of Micropollutant Degradation at Low Concentrations (MicroDegrade)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

"MicroDegrade aims to reveal bottlenecks of degradation, and to identify superior bioremediation strategies for a most notorious environmental pollution of our time: chemical micropollutants at low (sub-ug/L) concentrations. Finding out why micropollutants occur in ground and surface water despite the presence of bacterial degraders has become an elusive goal for microbiologists, environmental sci ...
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 1

 TERMINÉ 

Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging (DYNAHEALTH)

Date du début: 1 avr. 2015, Date de fin: 31 mars 2019,

The Gluco-Psychosocial Axis (GPA) concerns the interplay of factors determining glucose metabolism and insulin sensitivity and the neuroendocrine response resulting from exposure to psychosocial stress. A sub-optimal GPA influences the development of type 2 diabetes and related impairments with varying degrees of interplay between genetics and early growth (particularly adiposity and cognitive fun ...
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 14

 TERMINÉ 

Chromatin states in neurogenesis – from understanding chromatin loops to eliciting neurogenesis for repair (ChroNeuroRepair)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

The mechanisms regulating neural stem cells and their progression to neurogenesis are important not only to understand brain development and evolution, but also to elicit neurogenesis after brain injury. Our recent findings imply novel chromatin-associated proteins in the regulation of neural stem cell fate and neurogenesis. Therefore this project aims to understand the molecular mechanisms of how ...
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 1

 TERMINÉ 

DIabetes REsearCh on patient sTratification (DIRECT)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2019,

The overarching aims of the DIRECT consortium, consisting of 20 leading academic groups in diabetes and 5 EFPIA companies, are to identify biomarkers that address current bottlenecks in diabetes drug development and to develop a stratified medicines approach to treatment of type 2 diabetes with either existing or novel therapies.There is heterogeneity in who develops diabetes, the rate at which th ...
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 27

 TERMINÉ 

"Proposal to assess an innovative Immunotherapy, based on a thioredox peptide antigen, in a Phase I Trial for Type-1 Diabetes" (EXALT)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"Type-1 diabetes (T1D) is an autoimmune disease in which pancreatic β-cells are gradually destroyed by autoreactive T-cells recognising autoantigens (Auto-Ag) such as GAD65 and insulin. ImCyse, a small SME, has developed a new technology based on short synthetic peptides flanked with a thioredox motif, which silence the pathogenic immune response against several auto-Ag through activation of one a ...
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 7

 TERMINÉ 

Wheat and barley Legacy for Breeding Improvement (WHEALBI)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

WHEALBI will combine genomics, genetics and agronomy to improve European wheat and barley production in competitive and sustainable cropping systems. Germplasm representing the species diversity will be selected and characterised in unprecedented detail by next-generation-sequencing. Life history and adaptive traits will be evaluated in both transnational field experiments and a state-of-the-art p ...
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 20

 TERMINÉ 

The Neurobiology of Decision-Making in Eating - Innovative Tools (NUDGE-IT)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

Nudge-it engages internationally leading experts in the neurobiology of motivational behaviour, the neuroscience of reward pathways, the neuroendocrinology of homeostatic regulation of appetite, experimental psychology, functional brain imaging, behavioural economics, and computational modelling. They will work together to develop new tools and approaches that can provide the evidence needed to in ...
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 10

 TERMINÉ 

Multi-dimensional omics approach to stratification of patients with low back pain (PAIN-OMICS)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

"Pain-OMICS is a multidisciplinary consortium of leading clinical, academic and SME researchers in pain and different omics technologies. Genome-wide association studies identified a number of loci associated with pain, but the level of knowledge about underlying mechanisms of different pain syndromes as well as individual variation in the disease course remains inadequate. Pain-OMICS will capital ...
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 11

 TERMINÉ 

Validation and Molecular Characterization of Novel Glucagon-Thyroid Hormone Conjugates for the Efficient Management of Dyslipidemia and Fatty Liver Disease (GCG-T3 Dyslipidemia)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

Cardiovascular disease (CVD) is a leading cause of death worldwide. Compelling evidence indicates that dyslipidemia represent a key risk factor for CVD. Among approved lipid-lowering agents, statins are the most effective therapy for CVD. However, a substantial portion of high-risk patients treated with statins fail to achieve target cholesterol levels required for preventing CVD. Thus, sufficient ...
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 1

 TERMINÉ 

Systems Biology to Identify Molecular Targets for Vascular Disease Treatment (SYSVASC)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

Asymptomatic vascular damage accumulates for years before patients are identified and subjected to therapeutic measures. The limited knowledge on early vascular disease pathophysiology is reflected in the lack of therapeutic options. SysVasc aims to overcome this limitation by mounting a comprehensive systems medicine approach to elucidate pathological mechanisms, which will yield molecular target ...
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 19

 TERMINÉ 

Nuclear foundations of cellular potency (NUCLEARPOTENCY)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2018,

A fundamental question in biology is to understand the mechanisms underlying cell plasticity. Such plasticity or potency is essential to form multiple cell types upon differentiation. In mammals, upon fertilization and fusion of the gametes –two highly differentiated cells- intense chromatin remodeling and epigenetic reprogramming, the reversion into an undifferentiated state, are essential to res ...
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 2

 TERMINÉ 

Phytoremediation driven energy crops production on heavy metal degraded areas as local energy carrier (Phyto2Energy)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

The scientific and technological (S&T) goal of the project is to develop and validate an innovative approach combining phytoremediation and production of biomass on heavy metal contaminated (HMC) areas which could be used as local energy carrier. The S&T objectives of the project are as follows: Objective1) selection of optimal plant species suitable for phytoremediation driven energy crops produc ...
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 6

 TERMINÉ 

Reverse engineering the vertebrate molecular machinery for magnetic biomineralisation (MagnetoGenetics)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

In order to understand distributed biological networks and invent effective molecular therapies, we need to be able to image and control molecular processes across entire live organisms.Although an arsenal of genetically encoded fluorescent sensors and light-activated proteins has recently been developed to visualize and manipulate cellular activity, these methods all suffer from the poor penetrat ...
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 2

 TERMINÉ 

Functional Optoacoustic Neuro-Tomography (FONT)

Date du début: 1 juil. 2016, Date de fin: 31 déc. 2017,

The currently available neuroimaging tools, such as functional magnetic resonance imaging (fMRI) and optical microscopy, are not adequate for deep tissue volumetric visualization of brain activity in real time. The need for such solutions underlies the large scale multi-year European Human Brain Project as well as the BRAIN initiative promoted by the US government. Under the currently funded ERC-S ...
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 1

 TERMINÉ 

Upscaling human insulin-producing beta cell production by efficient differentiation and expansion of endoderm progenitors (HumEn)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

Despite progress in producing beta cells from human pluripotent stem cells (hPSCs) in recent years, full differentiation cannot be obtained in vitro. The HumEn project hypothesises that a fundamental understanding of the coupling between endodermal progenitor expansion and differentiation is relevant for elucidating how to a) generate glucose-responsive beta cells from hPSCs in vitro, and b) gener ...
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 9

 TERMINÉ 

Methods for Integrated analysis of Multiple Omics datasets (MIMOmics)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

MIMOmics develops statistical methods for the integrated analysis of metabolomics, proteomics, glycomics and genomic datasets in large studies. Our project is based on our involvement in studies participating in EU funded projects, i.e. GEHA, IDEAL, Mark-Age, ENGAGE and EuroSpan. In these consortia the primary goal is to identify molecular profiles that monitor and explain complex traits with nove ...
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 15