4 projets européens trouvés
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TERMINÉ
Systems biology of liver cancer: an integrative genomic-epigenomic approach (MODHEP)
Date du début: 1 janv. 2011, Date de fin: 30 juin 2016,
"Cancer is a complex disease involving multiple genetic and epigenetic events occurring, and influencing each other, over a long period of time. Understanding cancer, and ultimately developing effective targeted therapies, will therefore require that mutations and epigenetic alterations be systematically investigated during the multiple stages of disease development, from identifiable pre-neoplast ...
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18
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TERMINÉ
European Consortium on Synaptic Protein Networks in Neurological and Psychiatric Diseases (EUROSPIN)
Date du début: 1 janv. 2010, Date de fin: 30 juin 2014,
"Signalling at nerve cell synapses - a key determinant of all aspects of brain function - depends on the function of hundreds of synaptic proteins and their interactions. Numerous recent studies showed that a wide range of neurological and psychiatric diseases are 'synaptopathies' whose onset and progression are due to mutations of synaptic proteins and subsequent synaptic dysfunctions. EUROSPIN w ...
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19
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TERMINÉ
BrainTrain: Integrative neuroscience school on brain function and disease (BrainTrain)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,
Brain disorders, in particular neurodegenerative diseases and mental illnesses are among the most prevalent and debilitating diseases. Because they are chronic, quality of life and socio-economic prospects are dramatically impaired. Increased life expectancy further enhances the impact of brain dysfunction on society. In coming decades this burden will grow into one of most pressing and costly pro ...
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14
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TERMINÉ
Molecular Networks of Dopaminergic Neurons in Chordates (DOPAMINET)
Date du début: 1 févr. 2009, Date de fin: 31 juil. 2012,
"Background. Parkinson Disease is the second most common progressive neurodegenerative disorder. The selective degeneration of subsets of midbrain dopaminergic neurons is believed to be the primary cause for disruption of the ability to control movements. Objective. We propose to apply a highly interdisciplinary approach to construct complex networks consisting of protein coding genes, non-protein ...
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