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14 projets européens trouvés

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 TERMINÉ 

Modulation of mitochondrial complex I as a strategy to increase lifespan and prevent age-related diseases (ComplexI&Aging)

Date du début: 1 févr. 2011, Date de fin: 30 sept. 2016,

Nowadays, ageing is one of the main problems in Western society. The increase in the percentage of elderly people serves to strain the Social Security to the point of bankruptcy. The only way to alleviate the suffering caused by age-related degenerative disease is to fully understand the underlying forces which drive ageing and design strategies to delay it. Mitochondria are considered as central ...
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 2

 TERMINÉ 

Molecular by-pass therapy for mitochondrial dysfunction (MITO BY-PASS)

Date du début: 1 avr. 2009, Date de fin: 31 mars 2015,

Many eukaryotes, but not the higher metazoans such as vertebrates or arthropods, possess intrinsic by-pass systems that provide alternative routes for electron flow from NADH to oxygen. Whereas the standard mitochondrial OXPHOS system couples electron transport to proton pumping across the inner mitochondrial membrane, creating the proton gradient which is used to drive ATP synthesis and other ene ...
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 2

 TERMINÉ 

Pathogenesis of Type 1 Diabetes - Testing the Hygiene Hypothesis (DIABIMMUNE)

Date du début: 1 mars 2008, Date de fin: 28 févr. 2014,

"Preliminary data indicate that there is a strong association between the incidence of immune-mediated diseases and improving standard of living and hygiene. One of the steepest gradient in standard of living worldwide is present at the border between Russian Karelia and Finland with a sevenfold difference in the gross national product, while Estonia represents a country in rapid transition. These ...
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 12

 TERMINÉ 

Parkinson disease susceptibility gene mutations in Drosophila melanogaster and the therapeutic potential of transgenes alternative oxidase and alternative NADH dehydrogenase (DroMit)

Date du début: 1 août 2011, Date de fin: 31 janv. 2014,

Mutations in human genes parkin and DJ-1 cause susceptibility to Parkinson's disease (PD). Both genes have functions linking them to mitochondria and oxidative stress. Parkin protein is a ubiqutin E3 ligase which targets damaged proteins for proteasomal degradation and it has also been shown to localize to dysfunctional mitochondria. Protein DJ-1 has functions as a ROS scavenger and a gene express ...
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 1

 TERMINÉ 

European Study to Establish Biomarkers of Human Ageing (MARK-AGE)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,

The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but in all cases their variab ...
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 28

 TERMINÉ 

Prostate Research Organizations-Network of Early Stage Training (PRO-NEST)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

"New and recent developments have revolutionized the prostate cancer research and clinical arenas, requiring the next generation scientists to have comprehensive knowledge and expertise in basic, clinical and applied research. PRO-NEST offers young researchers a European integrated, multi-disciplinary training programme to become an independent and all-round scientist and team leader in (prostate) ...
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 18

 TERMINÉ 

Media Accountability and Transparency in Europe (MediaAcT)

Date du début: 1 févr. 2010, Date de fin: 31 juil. 2013,

In this proposal, we suggest a comparative European research project on media accountability systems in EU member states as indicators for media pluralism in Europe. The project will analyze the development and impact of established media accountability systems (i.e. press councils, ethics codes) as well as new media accountability systems emerging in the Internet (i.e. media criticism in blogs). ...
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 14

 TERMINÉ 

PROPROTEIN CONVERTASE FURIN AS A REGULATOR OF IMMUNE RESPONSES (Furin in Immunity)

Date du début: 1 juin 2009, Date de fin: 31 mai 2013,

Backgound: Interleukin (IL)-12 induced T helper (Th) 1 polarization is critical for adequate cell-medated immune responses against intracellular pathogens such as M. tuberculosis. To gain insights into Th1 type immunity I performed a genome wide analysis for IL-12 target genes. The results unequivocally identified proprotein convertases (PC) furin as a novel IL-12/Stat4 target gene. Furin has been ...
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 1

 TERMINÉ 

health-economic modelling of PREvention strategies for Hpv-related Diseases in European CounTries (PREHDICT)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2013,

"The goals of the PREHDICT study are to determine prerequisites and strategies for vaccination in European countries and to predict the impact of vaccination on screening programmes. To achieve these goals, a multiple HPV type transmission model will be built to describe the type-specific incidence and clearance of HPV infections. This model will be linked to an individual-based simulation model u ...
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 14

 TERMINÉ 

Prostate cancer: profiling and evaluation of ncRNA (ProspeR)

Date du début: 1 févr. 2008, Date de fin: 31 juil. 2012,

Annually, over 200 000 new prostate cancer cases are diagnosed in Europe. This number is expected to further increase due to widespread use of prostate specific antigen (PSA) tests on asymptomatic men and an aging population. This leads to high rate of over-detection, where most cases will never experience cancer symptoms during their lifetime. Hence, our current lack of means to predict prostate ...
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 8

 TERMINÉ 

FUTURAGE: A Roadmap for Ageing Research (FUTURAGE)

Date du début: 1 sept. 2009, Date de fin: 31 déc. 2011,

"FUTURAGE aims to produce the definitive road map that will guide European research on ageing and health for the next 10-15 years. It represents plans for the most extensive consultation ever conducted in this field and for the mobilisation of not only the leading scientists but also the stakeholders that will determine the fate of the road map. FUTURAGE combines all of the major coordination acti ...
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 24

 TERMINÉ 

"Transnationalisation, Migration and Transformation: Multi-Level Analysis of Migrant Transnationalism (TRANS-NET)" (TRANS-NET)

Date du début: 1 mars 2008, Date de fin: 28 févr. 2011,

"The objective of this project is to clarify and compare the complex process of transnationalism. During the past few years, transnationalism has attained ever greater importance and topicality due to the increase in transnational mobility of people. In order to attain a comprehensive and valid insight into the topic in question we adopt a multilevel approach. The research conducted in Estonia, Fi ...
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 8

 TERMINÉ 

Intangible Assets and Regional Economic Growth (IAREG)

Date du début: 1 févr. 2008, Date de fin: 31 juil. 2010,

"The objective of IAREG is to analyse the role played by intangible assets (IA) in the generation of innovation, competitiveness and consequently economic growth and increases in productivity at regional level with a special emphasis on the geographical space in which such processes occur. The specific objectives of the project will be: To develop new indicators for improving the measuring of som ...
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 13

 TERMINÉ 

PREPARATORY PHASE PROJECT FOR A MAJOR UPGRADE OF THE COUNCIL OF EUROPEAN SOCIAL SCIENCE DATA ARCHIVES (CESSDA) RESEARCH INFRASTRUCTURE (CESSDA-PPP)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2010,

"This proposal for a major upgrade to the CESSDA Research Infrastructure is a response to the general principles and vision set out in the 2004 Blueprint for the European Research Obsrvatory for the Humanities and Social Science and will meet the goals set out in that report to ‘strengthen interdisciplinary and cross-border collaboration and comparative research on a European dimension… enhance th ...
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 17