13 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
A Systems medicine approach to chronic inflammatory disease (SYSCID)
Date du début: 1 janv. 2017, Date de fin: 31 mars 2022,
"The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, Twins ...
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16
Participants partenaires
TERMINÉ
The inflammatory gene expression program in macrophages: An integrative approach for the systematic characterization of transcriptional co-regulators (MEDICI)
Date du début: 1 nov. 2016, Date de fin: 31 oct. 2021,
Tissue responses to microbial and endogenous danger signals involve the activation of both resident and monocyte-derived macrophages, as well as the coordinated inducible expression of hundreds of inflammatory genes. Gene transcription is controlled by the information contained in thousands of genomic regulatory elements (enhancers and promoters), which is first read by transcription factors (TFs ...
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2
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TERMINÉ
Innovative Dermatology Healthcare based on Label-Free Spectral Optoacoustic Mesoscopy (INNODERM)
Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,
Multispectral Optoacoustic Tomography (MSOT) brings a revolution to bio-optical imaging. Being insensitive to photon scattering, MSOT dramatically improves upon conventional bio-optic barriers by enabling (1) three-dimensional high-resolution optical imaging deep inside tissues (several millimetres to centimetres), by (2) high-scalability, ranging from optical-resolution microscopy to acoustic-res ...
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6
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TERMINÉ
European Sepsis Academy: towards new biomarkers to improve sepsis management (ESA -ITN)
Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,
ESA-ITN will break through the state of the art in sepsis diagnostics and will train 15 early-stage researchers (ESRs) to determine the clinical potency of a variety of new complementary sepsis biomarkers. These cover the full range of the antiinflammatory response in sepsis, at genetic, molecular and cellular level. Rapid and practical biomarker diagnostics for sepsis will be developed by buildin ...
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7
Participants partenaires
TERMINÉ
Efficacy and safety of low-dose IL-2 (ld-IL-2) as a Treg enhancer for anti-neuroinflammatory therapy in newly diagnosed Amyotrophic Lateral Sclerosis (ALS) patients (MIROCALS)
Date du début: 1 sept. 2015, Date de fin: 31 août 2019,
Amyotrophic Lateral Sclerosis (ALS) is a fatal degenerative disorder of the brain and spinal cord affecting some 40,000 individuals in Europe, causing 11,000 deaths each year. Our pioneering work on riluzole showed that it is possible to modify ALS progression but all subsequent trials of potential neuroprotective agents have failed. Thus, drug development in ALS, including trial design, patient s ...
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12
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TERMINÉ
MEsenchymal stem cells to Reduce Liver INflammation (MERLIN)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,
"Prevalence of liver disease is c6% (29 million people) in the EU with mortality rates from chronic liver diseases estimated at 14.3 per 100.000 in the EU-25 in 2004. Most liver diseases have a significant inflammatory component that underpins liver damage and fibrogenesis, yet current therapies have limited effectiveness. Safe novel anti-inflammatory therapies would satisfy a large unmet need for ...
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9
Participants partenaires
TERMINÉ
Advanced Immunization Technologies (ADITEC)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2017,
Vaccines so far have been developed mostly by following an empiric approach. To prevent and possibly cure unresolved and emerging infectious diseases we need to fully exploit the potential of the human immune system. Progress in science and technology makes it possible to achieve what was previously deemed impossible. The scope of this project is to produce knowledge necessary to develop novel and ...
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53
Participants partenaires
TERMINÉ
BeTheCuRE (BTCURE)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2017,
BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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41
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TERMINÉ
TargetIng novel MEchanisms of Resolution in inflammation (TIMER)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
Resolution of inflammation is a key determinant of pathology, and an active process which involves diverse pathways and molecules. The general objective of the TIMER Consortium is to identify and validate new molecules involved in the resolution of inflammation as a basis for the development of innovative therapeutic strategies in chronic inflammatory and autoimmune diseases. The project will invo ...
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13
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TERMINÉ
ICT-enabled, cellular artificial liver system incorporating personalized patient management and support (d-LIVER)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,
d-LIVER applies scenario-driven development methodologies to address an unmet need for bio-artificial liver support via continuous detoxification as remote transient therapy at the Point-of-Need. The liver is a complex organ with various vital functions in synthesis, detoxification and regulation; its failure is life-threatening and the only curative treatment is transplantation. Whilst awaiting t ...
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15
Participants partenaires
TERMINÉ
Systems Biology of T-cell Activation in Health and Disease (SYBILLA)
Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,
T-cell activation, whether induced by pathogens or auto-antigens, is a complex process relying on multiple layers of tightly controlled intracellular signalling modules that form an intricate network. Defects in this network can cause severe and chronic disorders such as autoimmune diseases. Although 5% of the population suffer from these diseases, only a few therapeutic treatments are available. ...
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22
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TERMINÉ
Advanced Teaching and TRaining for Adoptive Cell Therapy (ATTRACT)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,
Considerable resources are devoted to fighting cancer throughout Europe, yet these efforts are not producing the results that health practitioners and citizens might expect. This is partly due to the fragmentation and duplication of research efforts within Member states and the lack of co-ordination at European level. However it can also be attributed to the need to retain and most importantly dev ...
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16
Participants partenaires
TERMINÉ
"Early diagnosis, treatment and prevention of mood disorders targetting the activated inflammatory response system" (MOODINFLAME)
Date du début: 1 nov. 2008, Date de fin: 30 avr. 2013,
"Partners come from 10 European countries to achieve two main objectives: A) The further exploration of 3 animal models (the OBX rat, GS rat and NOD mouse) characterized by an activated immune response system (IRS), an abnormal tryptophan catabolism and a depressive-like behaviour to study the pathogenesis of inflammation-related mood disorders and the efficacy/working mechanism of anti-inflammat ...
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