3 projets européens trouvés
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TERMINÉ
Treating stroke with Affibody molecules targeting the inflammatory mediator HMGB1 (COUNTERSTROKE)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
The scope of the project is to generate a candidate drug targeting the inflammatory mediator High mobility group box 1 protein (HMGB1) to be used in treatment of stroke. The candidate drug will be validated in animal models, characterized and optimized for subsequent clinical development.Stroke remains a leading cause of death and disability throughout the world. Within EU, more than 500 000 perso ...
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6
Participants partenaires
TERMINÉ
Activation of vasculature associated stem cells and muscle stem cells for the repair and maintenance of muscle tissue (Endostem)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,
We propose to develop new strategies to mobilize skeletal muscle tissue-associated stem cells as a tool for efficient tissue repair. This will be combined with exploring novel approaches that limit tissue damage, and will focus on agents that modify muscle and muscle vasculature progenitor cells. These molecules include nitric oxide associated with non-steroidal anti-inflammatory drugs, HMGB1, Cri ...
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22
Participants partenaires
TERMINÉ
Nucleosome Structure & Function across Biological Scales and Biological Function (NUCLEOSOME4D)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,
Chromatin packages a few meters of DNA into a nucleus measuring a few microns. This tight folding occurs by assembling DNA with histones into so-called nucleosomes, thus ensuring the mechanical stability of our genome. On the flipside, this makes nucleosomes a formidable obstacle to the machines that read, copy or repair its DNA message. One of the fundamental questions in biology is to understand ...
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