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19 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Penumbral Rescue by Normobaric O=O Administration in Patients With Ischaemic Stroke and Target Mismatch ProFile: A Phase II Proof-of-Concept Trial (PROOF)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Ischemic stroke (IS), caused by occlusion of arteries that supply blood to the brain, remains a leading cause of mortality and morbidity in the world. Disruption of blood and oxygen supply to the brain leads to neuronal death in the ischemic core within minutes. The hypoperfused tissue surrounding the ischemic core, the penumbra, is at high risk for infarction over time but still salvageable. Neur ...
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 13

 TERMINÉ 

Towards Early Molecular Diagnostics of Schizophrenia (SZ_TEST)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Schizophrenia (SZ) is a severe mental disorder affecting more than 0.7% of the adult population. One of the most disabling and emotionally devastating illnesses known to man, SZ is also associated with considerable socioeconomic burden. In general, the chronic nature and the high degree of patient disability make SZ the fourth leading cause of disease burden across the globe with the management co ...
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 9

 TERMINÉ 

Paediatric Clinical Research Infrastructure Network (PedCRIN)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Children’s health is a major societal challenge for Europe and the world, requiring development of paediatric medicines and treatments strategies based on evidence derived from clinical trials demonstrating efficacy and safety in infants and children, rather than on uncritical extrapolation from adult data (over 50 % of the medicines used for children had not been tested in this specific age group ...
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 16

 TERMINÉ 

Effect of ALlopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome (ALBINO)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and consequently about 5-20.000 infants per year in Europe.Hypothermic treatment became the only established therapy to improve outcome after perinatal hypoxic-ischemic insults. Despite hypothermia and neonatal inte ...
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 18

 TERMINÉ 

Clinical study in Parkinson's disease with two unique goals: 1) Proof-of-concept of CDNF protein for disease modification; 2) Validation of clinically tested device for intracerebral drug delivery (TreatER)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

The main focus of TreatER is conducting a randomized, placebo-controlled, first-in-human, proof-of-concept, safety and efficacy study of intracerebrally administered CDNF protein therapy in patients with Parkinson’s disease (PD), using a neurosurgically implanted Drug Delivery System (DDS), which will also be clinically validated in the study. Thus the TreatER project has two independent goals, ei ...
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 12

 TERMINÉ 

Breaking the Nonuniqueness Barrier in Electromagnetic Neuroimaging (BREAKBEN)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,

By combining accurate magnetic measurements of neural activity with near-simultaneous high-definition measurements of cerebral structure – provided by novel methods in ultra-low-field magnetic resonance imaging (ULF MRI ) – we will be able to image the dynamics of human brain function at unprecedented resolution and reliability. BREAKBEN will achieve a revolution in neuroimaging; we aim at breakin ...
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 7

 TERMINÉ 

Neuropathic pain: biomarkers and druggable targets within the endogenous analgesia system (NEUROPAIN)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

Neuropathic pain has a high incidence in Europe and often affects the patient’s emotional balance and quality of life. Recent meta-analyses have shown that conventional analgesic drugs are not sufficiently effective in these patients and are limited by serious side effects. The search for new analgesics is extremely difficult despite identification of several new potential targets and enormous inv ...
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 12

 TERMINÉ 

Global Research in Paediatrics (GRiP)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2017,

Paediatric drugs (PD) lack appropriate testing. Most drugs have inadequate information about dosing regimen, dose adjustment and how to administer them. These are longstanding problems that unquestionably require concerted efforts at the international level. Both the US and the EU have introduced paediatric legislation that facilitates participation of children in research and pharmaceutical innov ...
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 24

 TERMINÉ 

Vitamin D And LIfestyle Intervention for Gestational Diabetes Mellitus (GDM) Prevention (DALI)

Date du début: 1 mars 2010, Date de fin: 31 déc. 2015,

Europe is facing a rapidly growing threat from Type 2 diabetes mellitus (T2D), which is undoubtedly associated with an unhealthy diet and a more sedentary lifestyle. Evidence is accumulating that gestational diabetes mellitus (GDM) may be playing a role in this process. Thus it provides a significant opportunity for preventing future T2D. Not only is GDM prevalence on the rise, but intrauterine ex ...
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 18

 TERMINÉ 

Adopting Hospital Based Health Technology Assessment in EU (AdHopHTA)

Date du début: 1 sept. 2012, Date de fin: 30 nov. 2015,

The use of HTA as a part of the decision-making process at national, regional, and international levels has evolved considerably over the past 35 years. However, still an important number of good-value innovative HTs never reach clinical practice while, in many instances, others with no significant added value actually do. This situation can be effectively overcome by approaching HTA at hospital l ...
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 11

 TERMINÉ 

Mechanisms of the Development of ALLergy (MEDALL)

Date du début: 1 déc. 2010, Date de fin: 31 mai 2015,

Causes explaining the epidemic of IgE-associated (allergic) diseases are unclear. MeDALL (Mechanisms of the Development of Allergy) aims at generating novel knowledge on mechanisms of allergy initiation, in particular in childhood. To understand how a complex network of genetic and environmental factors leads to complex allergic phenotypes, a novel stepwise, large and integrative translational app ...
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 24

 TERMINÉ 

Treatment of NEonatal seizures with Medication Off-patent: evaluation of efficacy and safety of bumetanide (NEMO)

Date du début: 1 oct. 2009, Date de fin: 31 mars 2015,

Neonatal hypoxic ischaemic encephalopathy (HIE) occurs in 2-3/1000 live births and is a major cause of both acute mortality and long-term neurodisability. Seizures are the hallmark of HIE. The clinical and electrographic seizure burden in babies with HIE can be considerable and is often not reduced by current antiepileptic drugs. Phenobarbitone remains the first line drug for neonatal seizures des ...
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 15

 TERMINÉ 

Brain Diagnostics and Monitoring in early neonatal period (BraDiMo) (BraDiMo)

Date du début: 1 mai 2011, Date de fin: 1 sept. 2014,

EU level payload from medical conditions associated with acute threat to brain in neonates (such as preterm birth or birthasphyxia) rises upto billions of euros each year. Yet the means to protect or monitor brains in neonatal intensive care units are far from optimal, and every improvement to this practice is likely to yield very high returns. The aim of this proposal is to fund development of re ...
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 1

 TERMINÉ 

Innovative functional foods based on sweet lupin protein for cardiovascular prevention (LUPICARP)

Date du début: 1 oct. 2011, Date de fin: 31 mars 2014,

The objective is to assess the health benefits on dislipidemia prevention of innovative food products based on lupin proteins, starting from some preliminary results provided by 2 past European collaborative projects (Healthy-Profood & Bioprofibre). The core RTD activity is the implementation of a multicenter randomized dietary intervention study with LDL-cholesterol as main end-point aimed to com ...
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 12

 TERMINÉ 

Pathogenesis of Type 1 Diabetes - Testing the Hygiene Hypothesis (DIABIMMUNE)

Date du début: 1 mars 2008, Date de fin: 28 févr. 2014,

"Preliminary data indicate that there is a strong association between the incidence of immune-mediated diseases and improving standard of living and hygiene. One of the steepest gradient in standard of living worldwide is present at the border between Russian Karelia and Finland with a sevenfold difference in the gross national product, while Estonia represents a country in rapid transition. These ...
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 12

 TERMINÉ 

Collaborative Oncological Gene-environment Study (COGS)

Date du début: 1 mai 2009, Date de fin: 31 janv. 2014,

The overarching goal of COGS is to identify individuals with an increased risk of breast, ovary and prostate cancer. Furthermore, we will evaluate the effect of inherited genetic variation on tumour characteristics and clinical outcome. We will do this through quantifying the role of genetic and environmental/lifestyle risk in the largest data set ever generated. In all, we will include over 200,0 ...
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 16

 TERMINÉ 

No Pain during infancy by adapting off-patent medicines (NeoOpioid)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2013,

Preterm and newborn infant may suffer from pain in the same way as adults. They are even more sensitive to pain due to immaturity of endogenous modulation. Thus, they should have the same human right to be alleviated from pain. The overall aim of this project is to assess effects and safety of opioid treatment in very preterm up to full term newborn infants in relation to pharmacokinetics predisp ...
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 13

 TERMINÉ 

European Stroke Research Network (EUSTROKE)

Date du début: 1 mars 2008, Date de fin: 31 août 2013,

The European Stroke Research Network (EUSTROKE) will be a collaborative effort that brings together researchers, government, industry, the non-profit sector and patient group associations. This network will put Europe at the forefront of stroke research through its multi-disciplinary research program, high-quality training for European scientists and clinicians, and national and global partnership ...
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 17

 TERMINÉ 

Hybrid MEG-MRI Imaging System (MEGMRI)

Date du début: 1 mai 2008, Date de fin: 30 avr. 2012,

"We will develop and validate hybrid magnetoencephalography (MEG) and magnetic resonance imaging (MRI) technology that will allow simultaneous structural (MRI) and functional (MEG) imaging of the human brain. MEG is a non-invasive 3D functional imaging with a high temporal resolution compared to other functional imaging but often suffers from a precise structural localization which will be solved ...
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 13