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30 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

SIMVASTATIN AND RIFAXIMIN AS NEW THERAPY FOR PATIENTS WITH DECOMPENSATED CIRRHOSIS (LIVERHOPE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Liver cirrhosis is a very common chronic disease and one of the leading causes of death in European. Moreover, cirrhosis has a marked impact in patients quality of life and represents a major burden for health systems. Treatment of cirrhosis is currently based on symptomatic management of complications and has not changed substantially in the last 20 years. There is an unmet need for therapies tha ...
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 18

 TERMINÉ 

Comorbid Conditions of Attention deficit / hyperactivity disorder (CoCA)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Understanding mechanisms underlying comorbid disorders poses a challenge for developing precision medicine tools. Psychiatric disorders are highly comorbid, and are among the last areas of medicine, where classification is driven by phenomenology rather than pathophysiology. We will study comorbidity between the most frequent psychiatric conditions, ADHD, mood/anxiety, and substance use disorders, ...
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 17

 TERMINÉ 

A Phase Ib/II study of MEK1/2 inhibitor PD-0325901 or MEK-162 with cMET inhibitor PF-02341066 in RASMT and RASWT (with aberrant c-MET) Colorectal Cancer Patients (MERCURIC)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2020,

Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ineffective treatments. Increased understanding of cancer biology, coupled with the implementation of “omi ...
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 13

 TERMINÉ 

REgenerative Stem cell therapy for STroke in Europe (RESSTORE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Stroke is the second leading cause of death in the world population. When not fatal, stroke often results in disability, due to motor and cognitive impairments, and secondary health problems affecting not only patients but also their families. Building on emerging preclinical and pilot clinical evidences, RESSTORE will focus on the clinical assessment of regenerative cell therapy to improve stroke ...
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 29

 TERMINÉ 

Brain injury and trauma monitoring using advanced photonics (BitMap)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Our vision is to develop a suite of standardised non-invasive devices that will provide essential information about brain health in neurocritical care and neuromonitoring, with a particular emphasis on 1. traumatic brain injury: the “silent epidemic of the third millennium” and 2. hypoxia in newborn children. Survivors present permanent neurological conditions that have a profound impact on the qu ...
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 11

 TERMINÉ 

Clinical evaluation of carbons of controlled porosity as a new therapeutic for the treatment of liver cirrhosis and non-alcoholic fatty liver disease. (CARBALIVE)

Date du début: 1 mai 2015, Date de fin: 31 oct. 2019,

Chronic liver disease affects about 29-million Europeans accounting for about 170,000 deaths at a cost of around €15.8bn. This chronic non-communicable disease is increasing at an alarming rate due to increasing European obesity, alcohol use and ageing. The three main causes of the disease; alcohol, fatty liver and viral hepatitis are amenable to prevention and treatment. Gut-derived endotoxins an ...
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 15

 TERMINÉ 

Deciphering PI3K biology in health and disease (Phd)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2019,

The Phosphoinositide 3-kinase (PI3K) pathway is at the core of multiple fundamental biological processes controlling metabolism, protein synthesis, cell growth, survival, and migration. This inevitably leads to the involvement of the PI3K signalling pathway in a number of different diseases, ranging from inflammation and diabetes to cancer, with PI3K pathway alterations present in almost 80% of hu ...
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 11

 TERMINÉ 

Mastering skills in the training Network for attention deficit hyperactivity and autism spectrum Disorders (MiND)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) are frequent, chronic and highly heritable neurodevelopmental disorders. Despite their societal importance, progress in understanding disease biology has been slow and no curative treatment options are available.The pan-European training network MiND aims to educate a new generation of researchers in the field of n ...
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 12

 TERMINÉ 

Aggression subtyping for improved insight and treatment innovation in psychiatric disorders (AGGRESSOTYPE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental ...
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 27

 TERMINÉ 

Raising the Quality of Teacher Education Programmes in Palestine

Date du début: 15 oct. 2015, Date de fin: 14 oct. 2018,

Despite numerous initiatives to upgrade the quality of the teaching profession in Palestine in recent years, there have been none that have led to a complete holistic reform of BA Primary Education degree programmes to reflect international practice. This project addresses this need by adopting a systemic, holistic approach to quality reform of all elements of BA Primary Education degree programm ...
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 6

 TERMINÉ 

Development of Health Informatics integrated curricula in Computing and Health-oriented undergraduate degrees

Date du début: 15 oct. 2015, Date de fin: 14 oct. 2018,

The HiCure project seeks to build capacities to develop an integrated curricula in Health Informatics as pathways within the undergraduate degrees of the faculties of Health and Information Technology, using a student-centred adaptive learning approach based on the bologna processes. It aims to develop two pathways, integrated within the current curricula, to bring continuity and achieve harmony ...
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 8

 TERMINÉ 

Creating medically-driven integrative bioinformatics applications focused on oncology, CNS disorders and their comorbidities (MedBioinformatics) (MedBioinformatics)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2018,

Progress in biomedical research and healthcare requires profiting from the huge amount of data and knowledge that are generated. However, most of the potential users have no means to efficiently exploit this wealth of information. Up to now, many of the efforts done for developing bioinformatics methods and applications have not produced the expected societal impact for different reasons, includin ...
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 13

 TERMINÉ 

European Training in Neural Regulation of Intestinal Function (NeuroGut)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

"Neurogastroenterology is a new and emerging medical/scientific subspecialty that currently has no formal training opportunities in medicine and related disciplines. It includes basic science aspects (neurophysiology, neurobiology, neuropsychology, psychophysiology) and clinical aspects (gastroenterology, neurology, internal medicine, surgery, psychology, psychosomatic medicine) of the neural cont ...
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 12

 TERMINÉ 

Early Prevention of Diabetes Complications in people with Hyperglycaemia in Europe (E-PREDICE)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,

"Background: A significant proportion of pre-diabetics, show macro and micro vascular complications associated with hyperglycaemia. Although many trials have demonstrated the efficacy of lifestyle and pharmaceutical interventions in diabetes prevention, no trial has evaluated the extent to which mid- and long-term complications can be prevented by early interventions on hyperglycaemia.Aims: To ass ...
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 37

 TERMINÉ 

Framework to respond to regulatory needs of future nanomaterials and markets (FutureNanoNeeds)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

Rapidly developing markets such as green construction, energy harvesting and storage, advanced materials for aerospace, electronics, medical implants and environmental remediation are potential key application targets for nanomaterials. There, nanotechnology has the potential to make qualitative improvements or indeed even to enable the technology. Impacts range from increased efficiency of energy ...
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 26

 TERMINÉ 

Assessment and mitigation of nano-enabled product risks on human and environmental health: Development of new strategies and creation of a digital guidance tool for nanotech industries (GUIDENANO)

Date du début: 1 nov. 2013, Date de fin: 30 avr. 2017,

The main objective of GUIDEnano is to develop innovative methodologies to evaluate and manage human and environmental health risks of nano-enabled products, considering the whole product life cycle. A strategy to identify hot spots for release of nanomaterials (NMs) will be followed by decision trees to guide on the use of (computational) exposure models and, when necessary, design of cost-effecti ...
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 34

 TERMINÉ 

Anti-Biopharmaceutical Immunization:Prediction and analysis of clinical relevance to minimize the risk (ABIRISK)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

The ABIRISK project provides an integrated approach to the study of immunization against biopharmaceuticals, bringing together a unique panel of experts from different disciplines. ABIRISK will involve many of the European leaders in rheumatology, gastroenterology, hemophilia and multiple sclerosis, caring for ~30,000 patients treated with biopharmaceuticals, with ~10,000 additional patients recru ...
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 39

 TERMINÉ 

European multicentre, randomised, phase III clinical trial of hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke (EuroHYP-1)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,

The consortium led by UKER and EuroHYP, the European Stroke Research Network for Hypothermia, proposes a large, multicentre clinical trial which will assess mild hypothermia as a novel treatment for ischemic stroke.Stroke is the second cause of death world-wide and the second cause of lost disability-adjusted life years in high-income countries. Stroke incidence rises exponentially with age, so it ...
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 38

 TERMINÉ 

OncoTrack - Methods for systematic next generation oncology biomarker development (ONCOTRACK)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2016,

We propose here an exhaustive analysis of the genome, exome, methylome and transcriptome of primary tumours and metastases from patients with colon carcinoma, based on a combination of deep sequencing and chip based techniques. Dependent on their availability, we shall also perform analyses of tumor stem cells, circulating tumor cells, free tumor DNA in serum and xenografts derived from the same p ...
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 22

 TERMINÉ 

Rational Therapy for Breast Cancer: Individualized Treatment for Difficult-to-Treat Breast Cancer Subtypes (RATHER)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2016,

"Cancer genotyping has identified a number of correlations between mutations in specific genes and responses to targeted anti-cancer drugs, with many mutations occurring in kinases or downstream signaling components. While there are several ongoing large-scale genome re-sequencing studies for the major cancer types, there is no systematic effort to investigate kinase mutations in distinct biologic ...
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 8

 TERMINÉ 

A European Platform for Translational Cancer Research (EUROCANPLATFORM)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2016,

Europe has a number of advantages as regards developing translational cancer research, yet there is no clear European strategy to meet the increasing burden posed by cancer. The FP6 Eurocan+Plus project analysed the barriers underlying the increasing fragmentation of cancer research and stressed the need to improve collaboration between basic/preclinical and comprehensive cancer centres (CCCs), in ...
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 29

 TERMINÉ 

European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR)

Date du début: 1 mars 2012, Date de fin: 30 juin 2016,

Diabetic retinopathy (DR), the leading cause of blindness among working-age individuals in developed countries has been classically considered to be a microcirculatory disease of the retina. However, there is growing evidence to suggest that retinal neurodegeneration is an early event in the pathogenesis of DR. For this reason, it is reasonable to hypothesize that therapeutic strategies based on n ...
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 18

 TERMINÉ 

Multicentre Preclinical Animal Research Team (Multi-PART)

Date du début: 1 sept. 2013, Date de fin: 31 août 2015,

Millions of Europeans still suffer the consequences of neurological disease, but the number of new drugs coming to market continues to fall. Reasons for the failure of stroke drug efficacy to translate from animals to clinical trials is probably best studied, but the problem is widespread. The economic and social costs of translational failure are substantial; a new approach to translational medic ...
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 12

 TERMINÉ 

WINTHERapeutics: development of a systems biology method to predict efficacy of cancer drugs to optimize individualized therapeutic decision and improve clinical outcome for cancer patients (WINTHER)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,

Relevance: WINTHER project focuses on the development and validation, in 24 months, of industry supported new tools and computational methods, to predict efficacy of drugs in cancer patientsCurrent medical needs: Selection of cancer targeted therapies based on molecular abnormalities (mutations /amplifications/ translocations) benefit today only to 10-40% of patients. For the remaining majority, ...
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 12

 TERMINÉ 

Modelling and predicting sensitivity to targeted therapies in colorectal cancers (COLTHERES)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

Effective and long term treatment of cancer is now in sight, but will ultimately require an increasingly ‘personalised’ approach where the ‘right’ combination of drugs will be administered to the ‘right’ patients, based on a detailed understanding of their genetic background and their co-associated sensitivity or resistance ‘biomarkers’. Efforts are specifically required to identify validated risk ...
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 11

 TERMINÉ 

United Europeans for the Development of Pharmacogenomics in Multiple Sclerosis (UEPHA-MS)

Date du début: 15 sept. 2008, Date de fin: 14 sept. 2012,

"Multiple sclerosis (MS) is a chronic inflammatory, disabling disease of the central nervous system. Recent studies suggest that over the last 50 years a disproportional increase in incidence of MS in women has taken place. The lifetime costs of MS exceed 1.5 million € per case in the UK, and are likely to be similar in other European countries. There is no definitive cure for MS. Immunomodulatory ...
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 12

 TERMINÉ 

Strengthening University-Enterprise linkages in Palestine

Date du début: 15 oct. 2012,

Enhancing cooperation between Higher Education Institutions (HEIs) and industry has become a critical issue to respond to the challenges of increasing employment opportunities and socio-economic growth (in Europe, this was already highlighted under the ‘Lisbon Strategy 2000’ and is now reinforced under the ‘Europe 2020 Strategy’).While there is a global economic deadlock, the situation is particul ...
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 11

 TERMINÉ 

EMII A2 S1L3B EMECW Lot 3

Date du début: 18 oct. 2010,

Lot 3b is a partnership of 16 European and Palestinian universities, led by the Vrije Universiteit Brussel (VUB). Its aim is to stimulate academic mobility at ali levels and both ways, but especially at PhD level since the project will support the Palestinian universities in setting up doctoral programmes. VUB and most of the European partners have extensive experience in academic cooperation with ...
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 15

 TERMINÉ 

Central Offices Responsible for the Integration at Home of Internationalisation as Assurance of quality in the Meda region

Date du début: 15 janv. 2010,

The project comes as result of the participation of 5 of the 6 partner universities in the programme Erasmus Mundus External Cooperation Windows. Given the importance to create structural measures that sustain the exchange of mobilities and facilities joint ventures, degrees and programmes this project proposal attempts to construct those pillars that will strengthen the harmonisation of higher ed ...
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 16

 TERMINÉ 

L03 - South Med. - oPt/Israël

Date du début: 15 juil. 2009,

Lot3.emecw.com is a partnership of 20 European, Israeli and Palestinian institutions for higher education, led by Vrije Universiteit Brussel (VUB). Its aim is to stimulate academic mobility at all levels (undergraduate, master, doctoral, postdoctoral and academic staff) from Israel and Palestine to Europe and vice versa.VUB and its European partners have extensive experience in academic cooperati ...
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 39