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 TERMINÉ 

Quantum spin simulators in diamond (Q-DIM-SIM)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Quantum interacting systems are at the forefront of contemporary physics, and pose challenges to our understanding of quantum phases, many-body dynamics, and a variety of condensed matter phenomena. Advances in quantum applications, including quantum computation and metrology, rely on interactions to create entanglement and to improve sensitivity beyond the standard quantum limit. In recent years ...
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 1

 TERMINÉ 

Lab Based Searches for Beyond Standard Model Physics Using Traps (TRAPLAB)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2021,

In this project I will measure a critical constant (beta-nu correlation) of the standard model to a precision of at least 0.1%, an order of magnitude improvement over the state of the art. The project will provide a platform for beyond standard-model (BSM) explorations, based on modern atom/ion trapping and a new accelerator facility.High precision measurements of beta decay correlations in trappe ...
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 1

 TERMINÉ 

Combinatorics with an analytic structure (CASe)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2021,

"Combinatorics, and its interplay with geometry, has fascinated our ancestors as shown by early stone carvings in the Neolithic period. Modern combinatorics is motivated by the ubiquity of its structures in both pure and applied mathematics.The work of Hochster and Stanley, who realized the relation of enumerative questions to commutative algebra and toric geometry made a vital contribution to the ...
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 2

 TERMINÉ 

Beyond the Elite: Jewish Daily Life in Medieval Europe (BeyondtheElite)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2021,

...hes proposed to access daily praxis seek to highlight tangible dimensions of religious life rather than the more common study of ideologies to date. This task is complex because the extant sources in Hebrew as well as those in Latin and vernacular were written by the learned elite and will require a broad survey of multiple textual and material sources.Four main strands will be examined and combin ...
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 1

 TERMINÉ 

Transient Relativistic eXplosions (TReX)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

The recent and upcoming deep and large field of view surveys has ascribed transient sources an ever-increasing role in 21st century astronomy. We propose to explore three relativistic transients: Compact binary mergers; Stellar disruption by massive black holes (TDEs) and Gamma-Ray Bursts (GRBs). Mergers are the prime targets of advanced Gravitational Waves (GW) detectors. Their detection will ope ...
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 1

 TERMINÉ 

Tracking the Dynamics of Human Metabolism using Spectroscopy-Integrated Liver-on-Chip Microdevices (OCLD)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

The liver is the main organ responsible for the systemic regulation of human metabolism, responding to hormonal stimulation, nutritional challenges, and circadian rhythms using fast enzymatic processes and slow transcriptional mechanisms. This regulatory complexity limits our ability to create efficient pharmaceutical interventions for metabolic diseases such as fatty liver disease and diabetes. I ...
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 1

 TERMINÉ 

High Dimensional Expanders, Ramanujan Complexes and Codes (HIEXP)

Date du début: 1 août 2016, Date de fin: 31 juil. 2021,

"Expander graphs have been playing a fundamental role in many areas of computer science. During the last 15 years they have also found important and unexpected applications in pure mathematics. The goal of the current research is to develop systematically high-dimensional (HD) theory of expanders, i.e., simplicial complexes and hypergraphs which resemble in dimension d, the role of expander graphs ...
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 1

 TERMINÉ 

Statistical learning and L2 literacy acquisition: Towards a neurobiological theory of assimilating novel writing systems (L2STAT)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

...arch axes: 1) we employ advanced methods from computational linguistics and machine learning to precisely characterize the statistics of four highly contrasting writing systems (English, Spanish, Hebrew, Chinese). 2) We study the learning that results from biologically-inspired computational models that are exposed to these statistics, to generate a priori predictions regarding what statistical pr ...
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 2

 TERMINÉ 

Mechanobiology of Bovine Reproduction (MechBiolRep)

Date du début: 1 juin 2016, Date de fin: 31 mai 2021,

The global demand for dairy products is expected to surge by 36% over the next decade in a manner that is progressively insatiable by existing technologies. The dairy industry relies on bovine reproduction, yet cow fertility is declining and the exact causes are not fully understood. It is clear, however, that the quality of bovine oocytes is decreasing. In mammals, the ovarian reserve of oocytes ...
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 1

 TERMINÉ 

Highly Competent and Safe Titanium(IV) Therapeutic Frameworks that are Cancer Targeted based on Complex 1, 2, and 3D Chemical Architectures (TiDrugArchitectures)

Date du début: 1 juin 2016, Date de fin: 31 mai 2021,

This proposal aims to develop custom designed anticancer therapeutic frameworks that are effective, stable, safe, and tumor targeted, based on the biocompatible TiIV metal. The Tshuva group has established that water stable phenolato TiIV complexes are especially effective as anticancer agents both in vitro and in vivo, with markedly reduced side effects. Optimal derivatives will be developed to c ...
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 1

 TERMINÉ 

Role of Tumour Suppressor Gene Products of Common Fragile Sites in Human Diseases (TSGPs-of-CFSs)

Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,

Common fragile sites (CFSs) are large chromosomal regions identified by conventional cytogenetics as sequences prone to breakage in cells subjected to replication stress. The interest in CFSs stems from their key role in DNA damage, resulting in chromosomal rearrangements. The instability of CFSs was correlated with genome instability in precancerous lesions and during tumour progression. Two oppo ...
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 1

 TERMINÉ 

Forecasting Surface Weather and Climate at One-Month Leads through Stratosphere-Troposphere Coupling (FORECASToneMONTH)

Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,

Anomalies in surface temperatures, winds, and precipitation can significantly alter energy supply and demand, cause flooding, and cripple transportation networks. Better management of these impacts can be achieved by extending the duration of reliable predictions of the atmospheric circulation. Polar stratospheric variability can impact surface weather for well over a month, and this proposed res ...
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 2

 TERMINÉ 

Ergodic theory and additive combinatorics (ErgComNum)

Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,

The last decade has witnessed a new spring for dynamical systems. The field - initiated by Poincare in the study of the N-body problem - has become essential in the understanding of seemingly far off fields such as combinatorics, number theory and theoretical computer science. In particular, ideas from ergodic theory played an important role in the resolution of long standing open problems in comb ...
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 1

 TERMINÉ 

From Peripheralized to Cell- and Organelle-Targeted Medicine: The 3rd Generation of Cannabinoid-1 Receptor Antagonists for the Treatment of Chronic Kidney Disease (CaNANObinoids)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,

Clinical experience with globally-acting cannabinoid-1 receptor (CB1R) antagonists revealed the benefits of blocking CB1Rs for the treatment of obesity and diabetes. However, their use is hampered by increased CNS-mediated side effects. Recently, I have demonstrated that peripherally-restricted CB1R antagonists have the potential to treat the metabolic syndrome without eliciting these adverse effe ...
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 1

 TERMINÉ 

Deep non-invasive imaging via scattered-light acoustically-mediated computational microscopy (DYNA-MIC)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,

Optical microscopy, perhaps the most important tool in biomedical investigation and clinical diagnostics, is currently held back by the assumption that it is not possible to noninvasively image microscopic structures more than a fraction of a millimeter deep inside tissue. The governing paradigm is that high-resolution information carried by light is lost due to random scattering in complex sample ...
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 1

 TERMINÉ 

The Molecular Basis of Somatic Nuclear Reprogramming (ReachingCompleteness)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,

The direct conversion approach and the generation of induced pluripotent stem cells (iPSCs) provide an invaluable resource of cells for disease modelling, drug screening, and patient-specific cell-based therapy. However, the directly converted cells are not stable, and the vast majority of iPSCs exhibit poor developmental potential as measured by stringent pluripotency tests. This suggests that th ...
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 1

 TERMINÉ 

Linking genetic resources, genomes and phenotypes of Solanaceous crops (G2P-SOL)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,

G2P-SOL is a research alliance bringing together the major European and International repositories of germplasm with public and private institutions active in genomics, phenotyping and breeding in the four major Solanaceous crops: potato, tomato, pepper and eggplant. These four crops constitute 66% of the value of European horticultural production, and over 65,000 accessions are available within t ...
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 20

 TERMINÉ 

Rounding the circle: Unravelling the biogenesis, function and mechanism of action of circRNAs in the Drosophila brain. (Brain circRNAs)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

Tight regulation of RNA metabolism is essential for normal brain function. This includes co and post-transcriptional regulation, which are extremely prevalent in neurons. Recently, circular RNAs (circRNAs), a highly abundant new type of regulatory non-coding RNA have been found across the animal kingdom. Two of these RNAs have been shown to act as miRNA sponges but no function is known for the tho ...
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 1

 TERMINÉ 

Securing Internet Routing from the Ground Up (SIREN)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

...ade up of dozens of thousands of smaller networks, called Autonomous Systems (ASes), ranging from multinational corporations to small businesses and schools, e.g., Google, Deutsche Telekom, AT&T, and Hebrew U. Routing between ASes is handled by the Border Gateway Protocol (BGP), which is the glue that holds the Internet together. Alarmingly, despite the Internet's critical societal and economic ro ...
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 1

 TERMINÉ 

Practically Relevant Theory of Deep Learning (TheoryDL)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

One of the most significant recent developments in applied machine learning has been the resurgence of "deep learning", usually in the form of artificial neural networks. The empirical success of deep learning is stunning, and deep learning based systems have already led to breakthroughs in computer vision and speech recognition. In contrast, from the theoretical point of view, by and large, we do ...
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 1

 TERMINÉ 

Rational Design of Photoreceptor Mutants with Desired Photochemical Properties (PhotoMutant)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

From a technological viewpoint photoreceptor proteins, the light-sensitive proteins involved in the sensing and response to light in a variety of organisms, represent biological light converters. Hence they are successfully utilized in a number of technological applications, e.g. the green-fluorescent protein used to visualize spatial and temporal information in cells. However, despite the ground- ...
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 1

 TERMINÉ 

circular RNA Biology Training Network: from biogenesis to biomarkers (circRTrain)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

CircRTrain focuses on circular RNAs (circRNAs), a new large class of single-stranded RNAs with covalently closed ends. CircRNAs have only very recently attracted high general interest and become the focus of an increasing number of publications: recent discoveries through sequencing technology and computational analyses have revealed the widespread existence of circRNAs in animal cells. Particular ...
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 8

 TERMINÉ 

Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia (TREATMENT)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

TREATMENT is a Marie Sklodowska Curie Innovative Training Network proposal directly addressing the need for high-level training and career paths in risk evaluation of drug induced metabolic dysfunctions, a relevant aspect, so far unexplored by traditional toxicology studies, but urgently needed to challenge current severe limitations of health care interventions in mental disorders. These patients ...
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 9

 TERMINÉ 

Harmonic Analysis and l-adic sheaves (HAS)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2020,

"In recent years there has been impressive development of the higher category theory and in particular development of the categorical counterpart of the Langlands conjecture over fields of finite characteristic. But until now, this development has had little bearing on the classical problems which deal with spaces of functions. The main goal of this proposal is to build the technique to apply the ...
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 1

 TERMINÉ 

Cross-Linguistic Acquisition of Sentence Structure: Integrating Experimental and Computational Approaches (CLASS)

Date du début: 1 sept. 2016, Date de fin: 31 août 2020,

...on of basic transitive and intransitive sentence structure (e.g., The man broke the window/The window broke) across six typologically different languages: English, K’iche’ Mayan, Japanese, Hindi, Hebrew and Turkish (at ages 3-4, 5-6, 9-10 and 18+ years). WP2 uses the same paradigms to investigate idiosyncratic language-specific generalizations within three of these languages. WP3 uses Artificial G ...
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 4

 TERMINÉ 

Light-Vapour Interactions at the Nanoscale (LIVIN)

Date du début: 1 juin 2015, Date de fin: 31 mai 2020,

The goal of this research is to develop a chip scale toolkit for exploring light-vapour interactions at the nanoscale. The integration of hot vapour cells with nanophotonics technology will be used for enhancing the interaction of light with vapours and for constructing miniaturized devices. Our main objectives are: I-developing an advanced and versatile platform which allows for the construction ...
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 1

 TERMINÉ 

Elucidation of the evolution of post-transcriptional regulation by characterizing the cnidarian microRNA pathway (CNIDARIAMICRORNA)

Date du début: 1 mai 2015, Date de fin: 1 mai 2020,

Over the past decade small RNAs such as microRNAs (miRNAs) and small interfering RNAs (siRNAs) have been shown to carry pivotal roles in post-transcriptional regulation and genome protection and to play an important part in various physiological processes in animals. miRNAs can be found in a very wide range of animals yet their functions were studied almost exclusively in members of the Bilateria ...
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 1

 TERMINÉ 

Tunneling Spectroscopy in van-der-Waals Device (TUNNEL)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

I will expand the experimental reach of tunneling spectroscopy to new materials and device geometries. The technique is ideal for tackling two challenges: (i) Probing Andreev bound states and Majorana states in graphene and topological insulators (TIs) coupled to superconductors, and (ii) realizing momentum-conserving tunneling.I will utilize a breakthrough in device fabrication to stack layered v ...
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 1

 TERMINÉ 

Striatal cholinergic cell assemblies in movement disorders (SynChI)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Pathological neuronal synchrony is the hallmark of many neurological disorders, including Parkinson’s disease (PD) and Huntington’s disease (HD), which further share deficits in cholinergic signaling. Moreover, recent findings have underscored the therapeutic relevance of the synchrony among striatal cholinergic interneurons (ChI) that orchestrate this signaling. They have shown that excessively ...
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 1

 TERMINÉ 

CellViewer: super-resolution systems microscopy to assess pluripotency and differentiation of stem cells at single cell level (CellViewer)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2020,

In this ambitious and multi-disciplinary proposal, we aim to develop new technologies that will allow us to visualize in single cells, in parallel and at the systems level, DNA, mRNAs and proteins with nanoscale resolution. We will refer to these novel technologies as the ‘CellViewer’: a unique cutting-edge high-throughput super-resolution (SR) microscopy approach (including new hardware and softw ...
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 6

 TERMINÉ 

The Diamond Revolution in Hyperpolarized MR Imaging – Novel Platform and Nanoparticle Targeted Probe (HYPERDIAMOND)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Non-invasively imaging small numbers of molecular probes, to help image particular targets or pathways in vivo, is currently undergoing a technological revolution. Recent breakthroughs in molecular hyperpolarization proved > 10,000-fold increase in sensitivity on conventional magnetic resonance imaging (MRI) systems, thus providing insight into previously unseen metabolic processes with enormous p ...
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 11

 TERMINÉ 

Functional diversity of single neurons in anatomically complex cortical networks (NEUROHUBS)

Date du début: 1 oct. 2014, Date de fin: 30 sept. 2019,

A fundamental quest in Neuroscience research is to reveal the function(s) of single neurons and networks. Understanding function seems to be on relatively solid grounds at the periphery where both anatomy and physiology converge in a simplified manner. However, as one ascends higher into the central nervous system, anatomy and physiology become increasingly more complex and functions become diffic ...
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 1

 TERMINÉ 

Modelling the PRocesses leading to Organised crime and TerrOrist Networks (PROTON)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2019,

PROTON aims at improving existing knowledge on the processes of recruitment to organised crime and terrorist networks (OCTN) through an innovative integration between social and computational sciences. Moving beyond the state of the art, this integration will support evidence-based policies at the international, national and local level. To achieve its aim, PROTON will complete three specific obje ...
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 20

 TERMINÉ 

ELIXIR-EXCELERATE: Fast-track ELIXIR implementation and drive early user exploitation across the life-sciences. (ELIXIR-EXCELERATE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that scienc ...
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 47

 TERMINÉ 

Behavior-dependent interactions between frontal and somatosensory cortices (AG-GF)

Date du début: 1 août 2016, Date de fin: 31 juil. 2019,

The mammalian brain integrates behaviorally relevant sensory information by recruiting large parts of the neocortex to enable precise perception, apt decisions and adequate actions. The large-scale interactions and the distinct roles of the various neocortical regions, namely frontal motor-related areas and posterior sensory-related regions, remain poorly understood. Here, we aim to characterize h ...
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 1

 TERMINÉ 

Understanding immune evasion by malaria parasites (MALMASQ)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

"The deadliest form of human malaria is caused by the protozoan parasite, Plasmodium falciparum, which annually infects millions worldwide. Its virulence is attributed to its ability to evade the human immune system, by modifying the host red blood cell surface to adhere to the vascular endothelium and to undergo antigenic variation. Antigenic variation is achieved through switches in expression o ...
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 1

 TERMINÉ 

Experience, Judgement, and Representation of World War II in an Age of Globalization (JUDGINGHISTORIES)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

“JudgingHistories” sets out to examine the epistemic premises innate to universalizing historical experience, by scrutinizing the quest for historical understanding and moral judgment against the backdrop of an emerging global cultural environment, fraught with multiple recollections, while using memories of World War II as the empirical core of the study. The pivotal constellation of research eme ...
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 1

 TERMINÉ 

Apartheid -- The Global Itinerary: South African Cultural Formations in Transnational Circulation, 1948-1990 (APARTHEID-STOPS)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

This proposal proceeds from an anomaly. Apartheid routinely breached the separation that it names. Whereas the South African regime was deeply isolationist in international terms, new research links it to the Cold War and decolonization. Yet this trend does not consider sufficiently that the global contest over the meaning of apartheid and resistance to it occurs on the terrain of culture. My proj ...
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 1

 TERMINÉ 

New Concepts in Bacterial Response to their Surroundings (BACTERIAL RESPONSE)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

Bacteria in nature exhibit remarkable capacity to sense their surroundings and rapidly adapt to diverse conditions by gaining new beneficial traits. This extraordinary feature facilitates their survival when facing extreme environments. Utilizing Bacillus subtilis as our primary model organism, we propose to study two facets of this vital bacterial attribute: communication via extracellular nanotu ...
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 1

 TERMINÉ 

Model theory and its applications: dependent classes (DEPENDENTCLASSES)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

Model theory deals with general classes of structures (called models).Specific examples of such classes are: the class of rings or the class ofalgebraically closed fields.It turns out that counting the so-called complete types over models in theclass has an important role in the development of model theory in general andstability theory in particular.Stable classes are those with relatively few co ...
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 1