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15 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

The Diamond Revolution in Hyperpolarized MR Imaging – Novel Platform and Nanoparticle Targeted Probe (HYPERDIAMOND)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Non-invasively imaging small numbers of molecular probes, to help image particular targets or pathways in vivo, is currently undergoing a technological revolution. Recent breakthroughs in molecular hyperpolarization proved > 10,000-fold increase in sensitivity on conventional magnetic resonance imaging (MRI) systems, thus providing insight into previously unseen metabolic processes with enormous p ...
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 11

 TERMINÉ 

Training the Next Generation of European Visual Neuroscientistsfor the benefit of innovation in health care and high-tech industry (NextGenVis)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2019,

The human visual brain can learn and adapt to change, which solves many of the problems posed by an ever-changing visual environment. However, to maintain a consistent overall representation of the visual world, the brain also has to retain previously acquired neuronal mechanisms. The key is to strike a balance between plasticity and stability.Increasing our knowledge about the stability and plast ...
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 10

 TERMINÉ 

Citicoline and deoxyglucose as new molecular imaging probes of DNP hyperpolarized MRI for cancer and neuroimaging (Hyperpolarized MRI)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Radioactively labeled deoxyglucose and choline are the leading molecular imaging probes for positron emission tomography (PET). The clinical applications for this imaging modality include brain function, cardiac imaging, and inflammation, along with oncological applications which are taking the lead. The radiation exposure associated with these examinations is limiting the use of this powerful tec ...
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 1

 TERMINÉ 

DEVELOPMENT OF TAILORED ANTIMICROBIAL TREATMENT REGIMENS AND NOVEL HOST- PATHOGEN INSIGHTS FOR RESPIRATORY TRACT INFECTIONS AND SEPSIS (TAILORED-Treatment)

Date du début: 1 août 2013, Date de fin: 31 juil. 2017,

Though of tremendous benefit, the overuse of antibiotics has lead to the emergence of antibiotic resistance and may cause adverse events that impact on patient healthcare. Current diagnostic tools for facilitating the appropriate use of antibiotics in patients are inadequate.We will establish a broad-based strategy (not limited to a particular antibiotic group) that can be implemented on a broad s ...
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 7

 TERMINÉ 

"King of hearts, joints and lungs; periodontal pathogens as etiologic factor in RA, CVD and COPD and their impact on treatment strategies." (TRIGGER)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,

"Extensive clinical and epidemiological data clearly shows that chronic periodontal disease (PD), the most prevalent infectious inflammatory disease of mankind, is strongly linked to systemic inflammatory diseases such as cardiovascular diseases (CVD) , rheumatoid arthritis (RA) , and chronic obstructive pulmonary disease (COPD) . Taking into account that up to 30% of the adult population worldwid ...
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 11

 TERMINÉ 

Training network for next generation vaccinologists (VACTRAIN)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

Vaccines are the most cost-effective health interventions available (WHO). The impact of vaccination on the health of the world’s population cannot be overstressed. Vaccinolgy is the multidisciplinary discipline of developing vaccine interventions it combines knowledge from basic sciences, medical sciences, public health and social sciences. Ideally a vaccinologists would be able to have a general ...
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 9

 TERMINÉ 

Molecular mechanism of calcium entry in the immune system (Cav in Immune System)

Date du début: 1 juin 2011, Date de fin: 31 mai 2015,

T-lymphocytes require calcium entry though the plasma membrane for their activation and function. Recently, several routes for calcium entry through the T cell plasma membrane after activation have been described. These include CRAC channels (Calcium Release of Activated Channels), TRP channels (Transient Receptor Potential) and inositol-1,4,5-trisphosphate receptors (IP3R). Herein we are proposin ...
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 1

 TERMINÉ 

Genetics of mitral valve prolapse (MVP-GEN)

Date du début: 1 juin 2011, Date de fin: 31 mai 2015,

Background: Mitral valve prolapse (MVP) is one of the most common valvular heart disorders. Twenty percent of MVP patients will develop severe complications, including congestive heart failure, endocarditis, atrial arrhythmias, embolic events and even sudden death. MVP is the most common cause of mitral regurgitation requiring surgical repair, however, very little is known about its etiology. MV ...
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 1

 TERMINÉ 

Orientation and disorientation in health and disease (Orientation)

Date du début: 1 juin 2013, Date de fin: 31 mai 2015,

Orientation in space, time, and person is the essence of the behaving self, and the bedrock of neurological and psychiatric mental status examination. States of disorientation may be the hallmark manifestation of several neuropsychiatric disorders. Despite orientation’s central role in health and disease, orientation has almost never been a subject for neuroscientific research. Consequently, there ...
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 1

 TERMINÉ 

ONLINE PORTAL FOR E-LEARNING AND SUPPORTING SOCIAL INCLUSION OF PEOPLE WITH DYSLEXIA (LITERACY)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2015,

The objective of the LITERACY project is to create an advanced online portal, which will aid both dyslexic youths and adults. The Portal will provide personalized e-learning programs, useful tools and methods for helping people with dyslexia to improve their abilities in reading, writing and then function in society. The Portal will also provide entry to an accessible online community of peers. Em ...
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 9

 TERMINÉ 

Role of TAM signaling in Retinal Homeostasis (TAM in AMD)

Date du début: 1 juin 2010, Date de fin: 31 mai 2014,

Macular and retinal degeneration are common blinding conditions which affect approximately 30% of individuals aged 75 years, and pose considerable socioeconomic burden. Lack of the daily phagocytosis of photoreceptor outer segments (POS) by Retinal Pigment Epithelium (RPE) cells is the basis of such retinal degeneration (RD). This proposal aims to characterize the role of TAM receptor Tyrosine Kin ...
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 2

 TERMINÉ 

"Myasthenias, a group of immune mediated neurological diseases: from etiology to therapy." (FIGHT-MG)

Date du début: 1 déc. 2009, Date de fin: 31 mai 2014,

"Myasthenia Gravis (MG) is a heterogeneous rare autoimmune neurological disease affecting the neuromuscular junction (NMJ). The molecular events causing and maintaining MG are still unknown and current treatments do not lead to remission and entail considerable side-effects stressing the need for improved therapies. We will address the: 1. Natural course of disease: determine factors associated wi ...
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 13

 TERMINÉ 

Innovative Techniques and Models to Study Glia-Neuron Interactions (EdU-GLIA)

Date du début: 15 sept. 2009, Date de fin: 14 sept. 2013,

It became evident over the last 20 years that glial cells are involved in virtually every aspect of nervous system function. Neurons and glia exchange chemical signals that are essential for the normal function of the nervous system, and are crucial in disease. Recently it was discovered that glial cells also act as neural stem cells both in early development and adulthood, and in synapse formatio ...
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 14

 TERMINÉ 

Prevalence, 1-year incidence and symptom severity of mental disorders in the elderly: Relationship to impairment, functioning (ICF) and service utilisation (MentDis_ICF65+)

Date du début: 1 oct. 2008, Date de fin: 31 mars 2013,

Reliable data on the prevalence and incidence of the spectrum of mental disorders in older people are currently lacking for the EU. Despite the availability of some national and a few cross-national cross-sectional studies with quite variable results, the size and burden of mental disorders in the elderly remains unclear. This has been attributed to a number of methodological factors (e.g. lack of ...
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 7

 TERMINÉ 

Development of culture conditions for the differentiation of hES cells into hepatocytes (LIV-ES)

Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,

"The liver is associated with many types of diseases which can only be treated by Orthotopic liver transplants. However, shortage of organ donors represents a major limitation for wide-application of this therapy. Additionally, expansion of fully-functional hepatocytes in vitro remains an important challenge for the drug discovery industry. Human Embryonic Stem cells (hESCs) offer a promising new ...
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 7