16 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Noise in gene expression as a determinant of virulence of the human pathogen Streptococcus pneumoniae (PneumoCell)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,
Not all cells in bacterial populations exhibit exactly the same phenotype, even though they grow in the same environment and are genetically identical. One of the main driving forces of phenotypic variation is stochasticity, or noise, in gene expression. Possible molecular origins contributing to noise in protein synthesis are stochastic fluctuations in the biochemical reactions of gene expression ...
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1
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TERMINÉ
European Lead Factory (EUC²LID)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
The European Lead Factory concept proposed by the EUC2LID Consortium relates to the discovery of novel small molecule candidates to serve as starting points for subsequent optimization to either drug candidates or high-quality pharmacological tools for the experimental validation of targets. The concept intends to bridge academic and applied research interests. The European Lead Factory will provi ...
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34
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TERMINÉ
Self replication in dynamic molecular networks (REPLI)
Date du début: 1 sept. 2011, Date de fin: 28 févr. 2017,
"Self-replicating molecules have most likely played an important role in the origin of life. This proposal explores the use of dynamic combinatorial chemistry for identifying new self-replicating molecules. We will make dynamic combinatorial libraries of macrocyclic molecules of different ring sizes that can exchange building blocks through reversible covalent chemistry. The building blocks are eq ...
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1
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TERMINÉ
Quantum Optics with Spins in Solid State: The Power of Ensembles (SolidSpinQopt)
Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,
Quantum states of optical pulses can be controlled with great accuracy, and in solid state precise control over quantum states of spins has been achieved. Conversion of such optical quantum states into spin quantum states, and vice versa, is highly relevant for quantum information science, but appears to be more challenging. This proposal aims at a study of such quantum-state conversion, and at de ...
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1
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TERMINÉ
Shedding light on catalyst systems for a brighter future with green oxidation chemistry (SolCat)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2016,
Sustainability in chemical synthesis requires that new methods and replacements for unsustainable existing methodologies should, where possible, focus on environmentally benign, atom- and energy-efficient processes that do not rely on toxic/precious metals. In this research program the focus is on the development of new sustainable and environmentally benign methodologies for selective oxidative t ...
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1
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TERMINÉ
Unveiling first light from the infant Universe (firstlight)
Date du début: 1 oct. 2010, Date de fin: 30 sept. 2016,
I request ERC funding to set up a dedicated science team to detect, for the first time, the redshifted 21-cm radio line emission of neutral hydrogen (HI) with LOFAR coming from the first billion years of the age of the Universe (the Epoch of Reionization and the Dark Ages ).The study of this pristine neutral hydrogen gas is a rapidly emerging field of astrophysics, both theoretically and observ ...
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1
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TERMINÉ
Modular Assembly of DNA-based systems; bio-inspired artificial allosteric assemblies (MADNA)
Date du début: 1 sept. 2011, Date de fin: 31 août 2016,
"Artificial allosteric systems, i.e. (semi-)synthetic systems that give an autonomous response to changes in their environment, are of great interest for applications as sensors, drug delivery and drug targeting.The overall aim of this proposal is the development of bio-inspired DNA-based artificial allosteric systems that are of interest for biological and bio-medical applications.In the present ...
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1
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TERMINÉ
Dynamical imprints of the evolutionary history of the Milky Way (GALACTICA)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2015,
Galactic Astronomy is entering a new era, driven by state-of-the-art instrumentation and large surveys, and by the dramatic leaps in our understanding of galaxy formation provided by the cosmological LCDM framework. These surveys have shown that the Galaxy is up for discoveries every single month, and have revealed the first footprints of past mergers. This Era will reach its summit when the Gaia ...
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1
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TERMINÉ
Replication and Adaptation in Molecular Networks (READ)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
"Systems Chemistry (the chemistry of complex mixtures of interacting molecules) is a rapidly developing new fronteir in the chemical sciences. Where chemistry has for centuries been a firmly reductionistic science, Systems Chemistry breaks with this tradition by focussing on complexity and emergent behaviour.This network brings together nearly all major academic players active in Europe on experim ...
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10
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TERMINÉ
Bridging Between Organocatalysis and Biocatalysis: The Powerful Enamine Mechanism of Organocatalysts Engineered into the Tautomerase Superfamily Scaffold (Prozymes)
Date du début: 1 mai 2010, Date de fin: 30 avr. 2015,
Proline and related secondary amines were found to be efficient organocatalysts of aldol, alkylation, Michael addition, and other challenging bond-forming reactions. The design of even more efficient systems that would allow extending this remarkable catalytic strategy to a useful and environmentally benign synthetic methodology would be highly desirable. This proposal aims to develop a new class ...
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1
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TERMINÉ
Catalytic Asymmetric C-C bond formation with Organo-Lithium reagents (Cat. Asymm. Lithium)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2014,
Carbon–carbon bond formation is at the hearth of chemistry and the development of new methodology for catalytic enantioselective C-C bond formation continues to be a major challenge for synthesis. After more than 80 years since the introduction of organolithium reagents, no general, highly enantioselective and practical catalytic C-C bond formation with organolithium reagents exists. In preliminar ...
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1
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TERMINÉ
Dynamic Combinatorial Chemistry at Lipid Membranes (DynaMem)
Date du début: 21 mai 2012, Date de fin: 20 mai 2014,
Molecular recognition at bilayer membranes is key to many vital processes in biology, yet notoriously difficult to study. Aim of this project is to introduce a new technique to this field: dynamic combinatorial chemistry. We propose to adapt reversible thioester chemistry to this end and use it for two different purposes:(i) Discovering new synthetic receptors that are optimized for operating at t ...
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1
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TERMINÉ
What is the molecular mechanism of mechanosensation? Mechanosensitive channel of large conductance, MscL, as a model (MECHANOSENSATION)
Date du début: 1 sept. 2008, Date de fin: 28 févr. 2014,
“Equipped with his five senses, man explores the universe around him and calls the adventure science” E.P. Hubble It is amazing how much we have learned about the working of our universe by using our five senses and how little we still know about the working of these senses themselves! Even though the molecular mechanism of sight, taste, and smell is known, we still don’t know how the mechanical s ...
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1
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TERMINÉ
Molecular Motors - Controlling movement at the nanoscale (MOLECULAR MOTORS)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2013,
The design of artificial molecular motors and machines is one of the major challenges in contemporary molecular sciences and bottom-up molecular nanotechnology. Whereas the protein-based molecular motors found in the living cell are amongst the most fascinating and complex structures found in nature and crucial to nearly every key biological process, the field of synthetic linear and rotary motors ...
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1
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TERMINÉ
Asymmetric Aza-Michael reactions catalyzed by hybrids metal-DNA (AMmDNACAT)
Date du début: 1 juil. 2011, Date de fin: 30 juin 2013,
This project deals with the development of new asymmetric reactions catalyzed by metal-DNA hybrids in aqueous medium. The present proposal has two main features:(i) The first feature lies on the design of novel catalytic systems putting into practice the concept of DNA-based asymmetric catalysis presented in the year 2005 by Ben. L. Feringa and G. Roelfes. This methodology involves the modular ass ...
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1
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TERMINÉ
Self-Replication in Dynamic Combinatorial Libraries (DynaRep)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2013,
The host group has recently made a remarkable discovery: the spontaneous emergence of self-replicating molecules from a complex mixture of continuously interconverting peptide-derived compounds (dynamic combinatorial libraries). This project builds on this discovery and aims to come to a complete understanding of the mechanism of replication. Based on this understanding new replicators will then b ...
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