26 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Space use by bees– radar tracking of spatial movement patterns of key pollinators (SpaceRadarPollinator)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,
Current radar tracking technology to monitor insect movements in space allows us to catch only glimpses of their spatial movements – it is severely constrained by the restricted range that can be covered, the fact that individuals can only be tracked one at a time, and the lack of a height dimension. Here we propose ground-breaking technology advances to make insect telemetry fit for the 21st cent ...
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2
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TERMINÉ
"Proposal to assess an innovative Immunotherapy, based on a thioredox peptide antigen, in a Phase I Trial for Type-1 Diabetes" (EXALT)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
"Type-1 diabetes (T1D) is an autoimmune disease in which pancreatic β-cells are gradually destroyed by autoreactive T-cells recognising autoantigens (Auto-Ag) such as GAD65 and insulin. ImCyse, a small SME, has developed a new technology based on short synthetic peptides flanked with a thioredox motif, which silence the pathogenic immune response against several auto-Ag through activation of one a ...
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7
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TERMINÉ
WILLIAM HARVEY INTERNATIONAL TRANSLATIONAL RESEARCH ACADEMY (WHRI-ACADEMY)
Date du début: 2 janv. 2014, Date de fin: 1 janv. 2019,
WHRI-ACADEMY is a new fellowship programme which will maximise the career development of the next generation of translational multidisciplinary researchers geared toward therapeutic innovation across rapidly developing and integrated life sciences and health care disciplines. This is a new transnational fellowship programme which has been organised with 15 partner organisations in the EU and Third ...
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1
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TERMINÉ
Strong, functional, tunable, self-assembling hydrogel scaffolds for regenerative medicine (STROFUNSCAFF)
Date du début: 1 août 2013, Date de fin: 31 juil. 2018,
This work proposes the development of novel material and fabrication platforms to generate strong, tunable, and highly biomimetic nanofibrous hydrogel scaffolds with an unparalleled level of control of both signaling and mechanical properties. The break-through element is the combination of elastin-like polymers (ELPs) and self-assembling peptide amphiphiles (PAs) to create nanofibrous hydrogels w ...
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1
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TERMINÉ
Building a Human Tumour Microenvironment (CANBUILD)
Date du début: 1 juin 2013, Date de fin: 31 mai 2018,
Even at their earliest stages, human cancers are more than just cells with malignant potential. Cells and extracellular matrix components that normally support and protect the body are coerced into a tumour microenvironment that is central to disease progression. My hypothesis is that recent advances in tissue engineering, biomechanics and stem cell biology make it possible to engineer, for the fi ...
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1
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TERMINÉ
Mechanical loading to direct stem cell differentiation (CSKFingerprints)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,
The main goal of this proposal is to induce and detect in real time and at single-cell level the differentiation of human mesenchymal stem cells using mechanical loads in 2D and 3D conditions. This proposal integrates disciplines from nanotechnology, bioengineering and cell and molecular biology. First we propose to develop a method to track the differentiation of stem cells in real time and at t ...
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1
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TERMINÉ
Novel dynamic self-assembling system: from hierarchical and biomimetic morphogenesis to functional materials (BIOMORPH)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2018,
"There is great need for radically new paradigms that significantly push forward the complexity, multiscale control, and functionality of novel materials. Molecular self-assembling strategies are continuously being explored for developing ever more precise and organized materials. The development of adaptive materials that can be morphed into complex shapes of hierarchical structure through bottom ...
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1
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TERMINÉ
Effective Bayesian Modelling with Knowledge before Data (BAYES-KNOWLEDGE)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2018,
This project aims to improve evidence-based decision-making. What makes it radical is that it plans to do this in situations (common for critical risk assessment problems) where there is little or even no data, and hence where traditional statistics cannot be used. To address this problem Bayesian analysis, which enables domain experts to supplement observed data with subjective probabilities, is ...
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1
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TERMINÉ
How force regulates cell function: a molecular and cellular outlook (ForceRegulation)
Date du début: 1 mars 2012, Date de fin: 28 févr. 2018,
Force is ubiquitous in nature and physical stimuli are crucial for cell function. How cells process forces determines key physiological processes such as cell growth and differentiation, in which cells divide or differentiate according to the chemical and physical cues cells receive from the extracellular matrix. Physical stimuli have also been involved in the development of pathological processes ...
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3
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TERMINÉ
Engineering macromolecular self-assembly of hyaluronan (HA)-based glycopolymers with peptides (SuprHApolymers)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,
Sugars and amino acids are natural building blocks which are used to form precisely regulated sequences in carbohydrates and proteins, respectively. While the field of proteomics has advanced immensely during the last past years, the field of glycomics is much less developed. The advance in synthetic polymer chemistry is allowing the possibility of controlling monomer sequences in synthetic macrom ...
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1
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TERMINÉ
Hydrothermal Biomass Upgrade into Carbon Materials and Levulinic Acid for Sustainable Catalysis (HydroCat)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,
The goal of this proposal is the conversion of lignocellulosic biomass into both nanostructured materials as well as valuable chemical platforms for biofuels production. This will be accomplished in one single hydrothermal treatment step.The resulting nanostructured carbons will be used as heterogenous catalysts for the conversion of the bio-derived chemicals from the liquid phase into biofuels. ...
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1
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TERMINÉ
Dissecting the genetic basis of divergent and convergent evolution: From individuals to species radiations (EVOGENO)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,
Advances in genomics offer new opportunities for identifying loci that behave unusually against a background of neutral variation. Detecting divergent sites among related individuals and taxa can shed light on the process of adaptive divergence, from non-random mating to the establishment of reproductive barriers. Conversely, identifying convergent sites among unrelated taxa can offer insights int ...
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1
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TERMINÉ
Muon Spectroscopy of Excited States (MuSES)
Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,
Muon spin spectroscopy has shown itself to be a very powerful probe of material properties, with Europe leading this research due to it operating half of the available muon sources in the world, but to date there has been very little work done on spectroscopy of excited states. In the first instance, this proposal will design and build an upgrade to an existing spectrometer (HiFi at ISIS) that wil ...
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1
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TERMINÉ
Exploiting Flow and Capillarity in Materials Assembly: Continuum Modelling and Simulation (FlowMat)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
"There is a growing interest in exploiting surface tension and hydrodynamic forces for materials assembly of colloids and complex fluids. For instance, the capillarity-driven motion of colloidal particles can be used to assemble them into two-dimensional ordered structures to coat surfaces. Non-Newtonian viscoplastic fluids can be precisely placed to form spanning 3D micro-architectures. The morp ...
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1
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TERMINÉ
Probing fundamental properties of the neutrino at the SNO+ Experiment (neutrinoSNO+)
Date du début: 1 nov. 2011, Date de fin: 30 juin 2017,
I propose a comprehensive programme of research on SNO+, a multi-purposeneutrino experiment that has the capacity to push forward the frontier of our knowledge in both neutrino and solar physics by addressing a wide range of physics topics. There are three main goals:A) To extend our understanding of neutrino oscillations by studying the suppression of low energy solar electron neutrino flux compo ...
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1
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TERMINÉ
Care Package for Treatment and Control of Visceral Leishmaniasis in East Africa (AfriCoLeish)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,
Visceral leishmaniasis (VL) is fatal if left untreated; East Africa is one of the key endemic areas in the world. Untreated patients are part of the retransmission cycle and VL-HIV co-infection is an additional emerging problem.Existing VL monotherapies are difficult to administer, toxic, costly and long with emerging resistance. Sodium stibogluconate and paromomycin (SSG&PM) has been developed as ...
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6
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TERMINÉ
Production and Analysis Evolution For Lattice Related Barrel Elements Under Operations With Advanced Robustness (POLARBEAR)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2016,
The PoLaRBEAR (Production and Analysis Evolution For Lattice Related Barrel Elements Under Operations With Advanced Robustness) project focuses on reliable novel composite aircraft structures based on geodesic technology aiming at a significant higher Robustness and Technology Readiness Level (TRL).While the global structural behavior of composite geodesic structures is investigated and understood ...
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13
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TERMINÉ
Genetic studies of pre-eclampsia in Central Asian and European populations (INTERPREGGEN)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2016,
Pre-eclampsia, one of the most dangerous cardiometabolic complications of pregnancy, claims the lives of 50,000 mothers and almost one million babies annually. Pre-eclampsia and other hypertensive disorders of pregnancy remain the second most common cause of maternal death. The incidence of pre-eclampsia in Central Asian countries is over twice as high as in western Europe. Inter-population differ ...
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13
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TERMINÉ
New permanent magnets for electric-vehicle drive applications (MAG-DRIVE)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,
"The future of road transport is electric - within the foreseeable future, pure electric vehicles (EVs) will populate our roads. Vital to the success of this transition is improved, next-generation motors based on improved magnetic materials; which provide high levels of flux at elevated temperatures, while retaining resistance to reverse magnetic fields and the corrosion problems associated with ...
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7
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TERMINÉ
Addictions and Lifestyles In Contemporary Europe – Reframing Addictions Project (ALICE RAP)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,
ALICE RAP is a Europe wide project of 43 partner research institutions involving 107 researchers from 25 European countries providing 1000 months of a plurality of scientific endeavour to analyse the place and challenges of addictions and lifestyles to the cohesion, organization and functioning of contemporary European society. Through integrated multidisciplinary research, a wide range of factors ...
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46
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TERMINÉ
Genomic and lifestyle predictors of foetal outcome relevant to diabetes and obesity and their relevance to prevention strategies in South Asian peoples (GIFTS)
Date du début: 1 févr. 2012, Date de fin: 31 janv. 2016,
Despite a strong genetic component to diabetes and obesity, the rapidly rising prevalence of these disorders is due to adaptation to a changing environment. The epicentre of the ‘diabetes epidemic’ is in South Asia and this is reflected in the migrant populations in Europe. Current prevention strategies are focused on adult life and target over-nutrition in high-risk adults. However, for many popu ...
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16
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TERMINÉ
Novel Statistical Methodology for Diagnostic/Prognostic and Therapeutic Studies and Systematic Reviews (MEDIASRES)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
...r promise. However, for leveraging such information for individualised diagnosis/prognosis, and treatment, the corresponding complex structures have to be adequately modelled and results have to be aggregated by corresponding advanced meta-analytic approaches. The main goal of the project is to establish a joint research-training programme by an interdisciplinary and intersectorial network for pro ...
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10
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TERMINÉ
Type 2 diabetes and obesity among sub-Saharan African native and migrant populations: dissection of environment and endogenous predisposition (RODAM)
Date du début: 1 janv. 2012, Date de fin: 30 sept. 2015,
"Migration from Sub-Saharan Africa (SSA) to Europe is increasing. The limited evidence suggests that the risk of type 2 diabetes (T2D) and obesity among SSA migrants is higher than among their SSA peers living in Africa and European host populations. The reasons for these observations are only poorly understood, but may involve migration-related changes in lifestyle, genetic predisposition as well ...
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9
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TERMINÉ
Colony Personality and Pace-of-life Syndrome in Bumblebees (ColonyPersPOLs)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,
Human personality is a rather self-evident phenomenon with which we are all intimately familiar. In recent years, evidence has been accumulating that personality is not only found in humans but also in a wide range of other animal species. Even if it was thought that there was no particular reason for animals to have personality, it is now recognised that consistent individual differences in behav ...
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1
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TERMINÉ
Sustainable Micronutrient Interventions to Control Deficiencies and Improve Nutritional Status and General Health in Asia (SMILING)
Date du début: 1 janv. 2012, Date de fin: 30 avr. 2014,
"Interventions to improve nutritional status are of critical importance to achieve Millennium Development Goals (MDGs). Micronutrient deficiencies, mainly iron, zinc, vitamin A and iodine deficiencies affect billions of people worldwide, are responsible for more than one million child deaths per year and prevent a third of the world’s children from reaching their intellectual and physical potenti ...
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12
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TERMINÉ
"Development of Vaccines for bTV, EHDV and AHSV" (ORBIVAC)
Date du début: 1 févr. 2010, Date de fin: 31 janv. 2014,
"The major outstanding challenges of orbivirus vaccine research is to develop vaccines that can afford a broad protective immune response against as many serotypes of each virus as possible, and to develop a high throughput DIVA assay (e.g. an ELISA). This project will use a coordinated multipartner approach to address these issues, to develop new experimental prototype vaccines and diagnostic app ...
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